arXiv subjects

Mark Ya. Azbel

Publications and source records attributed to Mark Ya. Azbel.

3 recordsLinked to original sources

arXiv2007

Non-coding DNA programs express adaptation and its universal law

Significant fraction (98.5% in humans) of most animal genomes is non- coding dark matter. Its largely unknown function (1-5) is related to programming (rather than to spontaneous mutations) of accurate adaptation to rapidly changing environment. Programmed adaptation to the same universal law for non-competing animals from anaerobic yeast to human is revealed in the study of their extensively quantified mortality (6-21). Adaptation of animals with removed non-coding DNA fractions may specify their contribution to genomic programming. Emergence of new adaptation programs and their (non-Mendelian) heredity may be studied in antibiotic mini-extinctions (22-24). On a large evolutionary scale rapid universal adaptation was vital for survival, and evolved, in otherwise lethal for diverse species major mass extinctions (25-28). Evolutionary and experimental data corroborate these conclusions (6-21, 29-32). Universal law implies certain biological universality of diverse species, thus quantifies applicability of animal models to humans). Genomic adaptation programming calls for unusual approach to its study and implies unanticipated perspectives, in particular, directed biological changes.

q-bio.GN↗

arXiv2007

Theory of genomic dark matter and biological relativity

Significant fraction (about 98.5% in humans, 24% in microbe Rickettsia prowazekii) of most animal genomes is non-coding DNA. Although recent studies established functions of its certain portions, it remains genomic dark matter. The paper unravels its unusual nature with time reversal approach. Any genome emerged in evolutionary selection of the fittest survivors. Survivability of modern species is extensively quantified. Accurate analysis establishes that under specified conditions it is dominated by the same law in species from human to single-cell yeast. Since all violators of the law perished in the previous evolution, it presents the exact law of unanticipated universal (rather than species specific natural) evolutionary selection of survivors. The law implies their rapid hereditary, thus genetic, adaptation which is navigated by operating system of non-coding DNA. Such adaptation to drastic environmental changes was a must for survival, thus evolved, in otherwise lethal major mass extinctions. Navigator genome allows for rapid, artificial included, biological changes (e.g., Methuselah lifespan). Universal law establishes biological relativity to age transformation in any species; quantifies applicability of animal models to humans; implies certain universality in biological complexity and reduces it to exact science problem. Evolutionary and experimental data corroborate all above conclusions. Further theoretical study and test-stone experiments are suggested.

q-bio.GN↗

arXiv2004

Comment on Why is the DNA Transition First Order? and Griffiths Singularities in Unbinding of Strongly Disordered Polymers

The papers [1,2] consider unbinding of a disordered heteropolymer. They find the first order phase transition [1] when disorder is strong (i.e. the ratio v of the binding energies is large; in DNA v is~1.1) and the Griffiths singularity, i.e. infinite order transition, otherwise [2]. The problem is important, since many physical phenomena map onto the same model (see refs. in [1, 2]). Drastic non-universality in the strength of disorder is unanticipated. Unfortunately, both titles are misleading: they claim the results which are proven for homopolymers only.

physics.bio-ph↗