arXiv subjects

Martin Cole

Publications and source records attributed to Martin Cole.

5 recordsLinked to original sources

arXiv2026

Diffeomorphic Cortical Alignment via Direct Warping of Streamline Endpoints

Cortical surface registration is often driven by local geometric descriptors (e.g., sulcal depth and curvature). While this approach achieves geometric correspondence, it neglects the long-range wiring constraints imposed by white-matter anatomy. Diffusion MRI tractography offers these crucial constraints; however, prior connectivity-informed pipelines typically align precomputed connectivity matrices, making the optimization highly sensitive to connectivity estimation and its resolution. In this paper, we introduce a novel connectivity-based surface registration method that aligns cortical surfaces by operating directly on white-matter fiber-tract endpoints. We model tract endpoints as a point cloud on the product manifold $\Omega \times \Omega$, where $\Omega$ represents the spherical domain of the inflated cortical hemispheres. Our alignment method iteratively (i) computes a small diffeomorphic warp for $\Omega$ by minimizing connectivity mismatch, and (ii) updates the endpoints based on this warp. The method relies on a geometric framework that ensures output warps are diffeomorphisms and has a final goal that optimizes the matching of well-known fiber bundles. Experiments on Human Connectome Project (HCP) data demonstrate improved tract-level correspondence, achieving higher connectivity-level overlap coefficients on major fiber bundles and stronger robustness across grid resolutions for $\Omega$ compared to state-of-the-art methods such as ENCORE and MSMAll.

cs.CV↗

arXiv2025

Alignment of Continuous Brain Connectivity

Brain networks are typically represented by adjacency matrices, where each node corresponds to a brain region. In traditional brain network analysis, nodes are assumed to be matched across individuals, but the methods used for node matching often overlook the underlying connectivity information. This oversight can result in inaccurate node alignment, leading to inflated edge variability and reduced statistical power in downstream connectivity analyses. To overcome this challenge, we propose a novel framework for registering high resolution continuous connectivity (ConCon), defined as a continuous function on a product manifold space specifically, the cortical surface capturing structural connectivity between all pairs of cortical points. Leveraging ConCon, we formulate an optimal diffeomorphism problem to align both connectivity profiles and cortical surfaces simultaneously. We introduce an efficient algorithm to solve this problem and validate our approach using data from the Human Connectome Project (HCP). Results demonstrate that our method substantially improves the accuracy and robustness of connectome-based analyses compared to existing techniques.

stat.ME↗

arXiv2023

Continuous and Atlas-free Analysis of Brain Structural Connectivity

Brain structural networks are often represented as discrete adjacency matrices with elements summarizing the connectivity between pairs of regions of interest (ROIs). These ROIs are typically determined a-priori using a brain atlas. The choice of atlas is often arbitrary and can lead to a loss of important connectivity information at the sub-ROI level. This work introduces an atlas-free framework that overcomes these issues by modeling brain connectivity using smooth random functions. In particular, we assume that the observed pattern of white matter fiber tract endpoints is driven by a latent random function defined over a product manifold domain. To facilitate statistical analysis of these high dimensional functional data objects, we develop a novel algorithm to construct a data-driven reduced-rank function space that offers a desirable trade-off between computational complexity and flexibility. Using real data from the Human Connectome Project, we show that our method outperforms state-of-the-art approaches that use the traditional atlas-based structural connectivity representation on a variety of connectivity analysis tasks. We further demonstrate how our method can be used to detect localized regions and connectivity patterns associated with group differences.

stat.CO↗

arXiv2022

Analyzing Brain Structural Connectivity as Continuous Random Functions

This work considers a continuous framework to characterize the population-level variability of structural connectivity. Our framework assumes the observed white matter fiber tract endpoints are driven by a latent random function defined over a product manifold domain. To overcome the computational challenges of analyzing such complex latent functions, we develop an efficient algorithm to construct a data-driven reduced-rank function space to represent the latent continuous connectivity. Using real data from the Human Connectome Project, we show that our method outperforms state-of-the-art approaches applied to the traditional atlas-based structural connectivity matrices on connectivity analysis tasks of interest. We also demonstrate how our method can be used to identify localized regions and connectivity patterns on the cortical surface associated with significant group differences. Code will be made available at https://github.com/sbci-brain.

stat.CO↗

arXiv2021

Selection of inverse gamma and half-t priors for hierarchical models: sensitivity and recommendations

While the importance of prior selection is well understood, establishing guidelines for selecting priors in hierarchical models has remained an active, and sometimes contentious, area of Bayesian methodology research. Choices of hyperparameters for individual families of priors are often discussed in the literature, but rarely are different families of priors compared under similar models and hyperparameters. Using simulated data, we evaluate the performance of inverse gamma and half-$t$ priors for estimating the standard deviation of random effects in three hierarchical models: the 8-schools model, a random intercepts longitudinal model, and a simple multiple outcomes model. We compare the performance of the two prior families using a range of prior hyperparameters, some of which have been suggested in the literature, and others that allow for a direct comparison of pairs of half-$t$ and inverse-gamma priors. Estimation of very small values of the random effect standard deviation led to convergence issues especially for the half-$t$ priors. For most settings, we found that the posterior distribution of the standard deviation had smaller bias under half-$t$ priors than under their inverse-gamma counterparts. Inverse gamma priors generally gave similar coverage but had smaller interval lengths than their half-$t$ prior counterparts. Our results for these two prior families will inform prior specification for hierarchical models, allowing practitioners to better align their priors with their respective models and goals.

stat.ME↗