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Mary Beth Landrum

Publications and source records attributed to Mary Beth Landrum.

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Targeted Quality Measurement of Health Care Providers

Assessing the quality of cancer care administered by US health providers poses numerous challenges due to meaningful heterogeneity in patient populations. Patients undergoing oncology treatment exhibit substantial variation in disease presentation among other crucial characteristics. In this paper, we present a framework for institutional quality measurement that addresses this patient heterogeneity. Our framework follows recent advancements in health outcomes research, conceptualizing quality measurement as a causal inference problem. This approach enables us to use flexible covariate profiles to target specific patient populations of interest. We use different clinically relevant covariate profiles and evaluate methods for case-mix adjustments. These adjustments integrate weighting and regression modeling approaches in a progressive manner in order to reduce model extrapolation and allow for provider effect modification. We evaluate these methods in an extensive simulation study, comparing their performance in terms of point estimates and estimated rankings. We highlight the practical utility of weighting methods that can generate stable weights when covariate overlap is limited and alert investigators when case-mix adjustments are infeasible without some form of extrapolation that goes beyond the support of the observed data. In our study of cancer-care outcomes, we assess the performance of oncology practices for different profiles that correspond to important types of patients who may receive cancer care. We describe how the methods examined may be particularly important for high-stakes quality measurement, such as public reporting or performance-based payments. These methods have the potential to help inform individual patient health care decisions and contribute to progress toward more personalized quality measurement.

stat.AP

Uncertainty in Lung Cancer Stage for Outcome Estimation via Set-Valued Classification

Difficulty in identifying cancer stage in health care claims data has limited oncology quality of care and health outcomes research. We fit prediction algorithms for classifying lung cancer stage into three classes (stages I/II, stage III, and stage IV) using claims data, and then demonstrate a method for incorporating the classification uncertainty in outcomes estimation. Leveraging set-valued classification and split conformal inference, we show how a fixed algorithm developed in one cohort of data may be deployed in another, while rigorously accounting for uncertainty from the initial classification step. We demonstrate this process using SEER cancer registry data linked with Medicare claims data.

stat.AP