arXiv subjects

Mathias Unberath

Publications and source records attributed to Mathias Unberath.

At least 37 records · Page 2Linked to original sources

arXiv2025

Benchmark of Segmentation Techniques for Pelvic Fracture in CT and X-ray: Summary of the PENGWIN 2024 Challenge

The segmentation of pelvic fracture fragments in CT and X-ray images is crucial for trauma diagnosis, surgical planning, and intraoperative guidance. However, accurately and efficiently delineating the bone fragments remains a significant challenge due to complex anatomy and imaging limitations. The PENGWIN challenge, organized as a MICCAI 2024 satellite event, aimed to advance automated fracture segmentation by benchmarking state-of-the-art algorithms on these complex tasks. A diverse dataset of 150 CT scans was collected from multiple clinical centers, and a large set of simulated X-ray images was generated using the DeepDRR method. Final submissions from 16 teams worldwide were evaluated under a rigorous multi-metric testing scheme. The top-performing CT algorithm achieved an average fragment-wise intersection over union (IoU) of 0.930, demonstrating satisfactory accuracy. However, in the X-ray task, the best algorithm achieved an IoU of 0.774, which is promising but not yet sufficient for intra-operative decision-making, reflecting the inherent challenges of fragment overlap in projection imaging. Beyond the quantitative evaluation, the challenge revealed methodological diversity in algorithm design. Variations in instance representation, such as primary-secondary classification versus boundary-core separation, led to differing segmentation strategies. Despite promising results, the challenge also exposed inherent uncertainties in fragment definition, particularly in cases of incomplete fractures. These findings suggest that interactive segmentation approaches, integrating human decision-making with task-relevant information, may be essential for improving model reliability and clinical applicability.

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arXiv2025

3D Path Planning for Robot-assisted Vertebroplasty from Arbitrary Bi-plane X-ray via Differentiable Rendering

Robotic systems are transforming image-guided interventions by enhancing accuracy and minimizing radiation exposure. A significant challenge in robotic assistance lies in surgical path planning, which often relies on the registration of intraoperative 2D images with preoperative 3D CT scans. This requirement can be burdensome and costly, particularly in procedures like vertebroplasty, where preoperative CT scans are not routinely performed. To address this issue, we introduce a differentiable rendering-based framework for 3D transpedicular path planning utilizing bi-planar 2D X-rays. Our method integrates differentiable rendering with a vertebral atlas generated through a Statistical Shape Model (SSM) and employs a learned similarity loss to refine the SSM shape and pose dynamically, independent of fixed imaging geometries. We evaluated our framework in two stages: first, through vertebral reconstruction from orthogonal X-rays for benchmarking, and second, via clinician-in-the-loop path planning using arbitrary-view X-rays. Our results indicate that our method outperformed a normalized cross-correlation baseline in reconstruction metrics (DICE: 0.75 vs. 0.65) and achieved comparable performance to the state-of-the-art model ReVerteR (DICE: 0.77), while maintaining generalization to arbitrary views. Success rates for bipedicular planning reached 82% with synthetic data and 75% with cadaver data, exceeding the 66% and 31% rates of a 2D-to-3D baseline, respectively. In conclusion, our framework facilitates versatile, CT-free 3D path planning for robot-assisted vertebroplasty, effectively accommodating real-world imaging diversity without the need for preoperative CT scans.

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arXiv2025

Counterfactual World Models via Digital Twin-conditioned Video Diffusion

World models learn to predict the temporal evolution of visual observations given a control signal, potentially enabling agents to reason about environments through forward simulation. Because of the focus on forward simulation, current world models generate predictions based on factual observations. For many emerging applications, such as comprehensive evaluations of physical AI behavior under varying conditions, the ability of world models to answer counterfactual queries, such as "what would happen if this object was removed?", is of increasing importance. We formalize counterfactual world models that additionally take interventions as explicit inputs, predicting temporal sequences under hypothetical modifications to observed scene properties. Traditional world models operate directly on entangled pixel-space representations where object properties and relationships cannot be selectively modified. This modeling choice prevents targeted interventions on specific scene properties. We introduce CWMDT, a framework to overcome those limitations, turning standard video diffusion models into effective counterfactual world models. First, CWMDT constructs digital twins of observed scenes to explicitly encode objects and their relationships, represented as structured text. Second, CWMDT applies large language models to reason over these representations and predict how a counterfactual intervention propagates through time to alter the observed scene. Third, CWMDT conditions a video diffusion model with the modified representation to generate counterfactual visual sequences. Evaluations on two benchmarks show that the CWMDT approach achieves state-of-the-art performance, suggesting that alternative representations of videos, such as the digital twins considered here, offer powerful control signals for video forward simulation-based world models.

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arXiv2025

Human-AI Collaboration and Explainability for 2D/3D Registration Quality Assurance

Purpose: As surgery increasingly integrates advanced imaging, algorithms, and robotics to automate complex tasks, human judgment of system correctness remains a vital safeguard for patient safety. A critical example is 2D/3D registration, where small registration misalignments can lead to surgical errors. Current visualization strategies alone are insufficient to reliably enable humans to detect these misalignments, highlighting the need for enhanced decision-support tools. Methods: We propose the first artificial intelligence (AI) model tailored to 2D/3D registration quality assessment, augmented with explainable AI (XAI) mechanisms to clarify the model's predictions. Using both objective measures (e.g., accuracy, sensitivity, precision, specificity) and subjective evaluations (e.g., workload, trust, and understanding), we systematically compare decision-making across four conditions: AI-only, Human-only, Human+AI, and Human+XAI. Results: The AI-only condition achieved the highest accuracy, whereas collaborative paradigms (Human+AI and Human+XAI) improved sensitivity, precision, and specificity compared to standalone approaches. Participants experienced significantly lower workload in collaborative conditions relative to the Human-only condition. Moreover, participants reported a greater understanding of AI predictions in the Human+XAI condition than in Human+AI, although no significant differences were observed between the two collaborative paradigms in perceived trust or workload. Conclusion: Human-AI collaboration can enhance 2D/3D registration quality assurance, with explainability mechanisms improving user understanding. Future work should refine XAI designs to optimize decision-making performance and efficiency. Extending both the algorithmic design and human-XAI collaboration elements holds promise for more robust quality assurance of 2D/3D registration.

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arXiv2025

Text-Driven Reasoning Video Editing via Reinforcement Learning on Digital Twin Representations

Text-driven video editing enables users to modify video content only using text queries. While existing methods can modify video content if explicit descriptions of editing targets with precise spatial locations and temporal boundaries are provided, these requirements become impractical when users attempt to conceptualize edits through implicit queries referencing semantic properties or object relationships. We introduce reasoning video editing, a task where video editing models must interpret implicit queries through multi-hop reasoning to infer editing targets before executing modifications, and a first model attempting to solve this complex task, RIVER (Reasoning-based Implicit Video Editor). RIVER decouples reasoning from generation through digital twin representations of video content that preserve spatial relationships, temporal trajectories, and semantic attributes. A large language model then processes this representation jointly with the implicit query, performing multi-hop reasoning to determine modifications, then outputs structured instructions that guide a diffusion-based editor to execute pixel-level changes. RIVER training uses reinforcement learning with rewards that evaluate reasoning accuracy and generation quality. Finally, we introduce RVEBenchmark, a benchmark of 100 videos with 519 implicit queries spanning three levels and categories of reasoning complexity specifically for reasoning video editing. RIVER demonstrates best performance on the proposed RVEBenchmark and also achieves state-of-the-art performance on two additional video editing benchmarks (VegGIE and FiVE), where it surpasses six baseline methods.

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arXiv2025

Constructing and Interpreting Digital Twin Representations for Visual Reasoning via Reinforcement Learning

Visual reasoning may require models to interpret images and videos and respond to implicit text queries across diverse output formats, from pixel-level segmentation masks to natural language descriptions. Existing approaches rely on supervised fine-tuning with task-specific architectures. For example, reasoning segmentation, grounding, summarization, and visual question answering each demand distinct model designs and training, preventing unified solutions and limiting cross-task and cross-modality generalization. Hence, we propose DT-R1, a reinforcement learning framework that trains large language models to construct digital twin representations of complex multi-modal visual inputs and then reason over these high-level representations as a unified approach to visual reasoning. Specifically, we train DT-R1 using GRPO with a novel reward that validates both structural integrity and output accuracy. Evaluations in six visual reasoning benchmarks, covering two modalities and four task types, demonstrate that DT-R1 consistently achieves improvements over state-of-the-art task-specific models. DT-R1 opens a new direction where visual reasoning emerges from reinforcement learning with digital twin representations.

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arXiv2025

Fast Reasoning Segmentation for Images and Videos

Reasoning segmentation enables open-set object segmentation via implicit text queries, therefore serving as a foundation for embodied agents that should operate autonomously in real-world environments. However, existing methods for reasoning segmentation require multimodal large language models with billions of parameters that exceed the computational capabilities of edge devices that typically deploy the embodied AI systems. Distillation offers a pathway to compress these models while preserving their capabilities. Yet, existing distillation approaches fail to transfer the multi-step reasoning capabilities that reasoning segmentation demands, as they focus on matching output predictions and intermediate features rather than preserving reasoning chains. The emerging paradigm of reasoning over digital twin representations presents an opportunity for more effective distillation by re-framing the problem. Consequently, we propose FastReasonSeg, which employs digital twin representations that decouple perception from reasoning to enable more effective distillation. Our distillation scheme first relies on supervised fine-tuning on teacher-generated reasoning chains. Then it is followed by reinforcement fine-tuning with joint rewards evaluating both segmentation accuracy and reasoning quality alignment. Experiments on two video (JiTBench, RVTBench) and two image benchmarks (ReasonSeg, LLM-Seg40K) demonstrate that our FastReasonSeg achieves state-of-the-art reasoning segmentation performance. Moreover, the distilled 0.6B variant outperforms models with 20 times more parameters while achieving 7.79 FPS throughput with only 2.1GB memory consumption. This efficiency enables deployment in resource-constrained environments to enable real-time reasoning segmentation.

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arXiv2025

Reasoning Text-to-Video Retrieval via Digital Twin Video Representations and Large Language Models

The goal of text-to-video retrieval is to search large databases for relevant videos based on text queries. Existing methods have progressed to handling explicit queries where the visual content of interest is described explicitly; however, they fail with implicit queries where identifying videos relevant to the query requires reasoning. We introduce reasoning text-to-video retrieval, a paradigm that extends traditional retrieval to process implicit queries through reasoning while providing object-level grounding masks that identify which entities satisfy the query conditions. Instead of relying on vision-language models directly, we propose representing video content as digital twins, i.e., structured scene representations that decompose salient objects through specialist vision models. This approach is beneficial because it enables large language models to reason directly over long-horizon video content without visual token compression. Specifically, our two-stage framework first performs compositional alignment between decomposed sub-queries and digital twin representations for candidate identification, then applies large language model-based reasoning with just-in-time refinement that invokes additional specialist models to address information gaps. We construct a benchmark of 447 manually created implicit queries with 135 videos (ReasonT2VBench-135) and another more challenging version of 1000 videos (ReasonT2VBench-1000). Our method achieves 81.2% R@1 on ReasonT2VBench-135, outperforming the strongest baseline by greater than 50 percentage points, and maintains 81.7% R@1 on the extended configuration while establishing state-of-the-art results in three conventional benchmarks (MSR-VTT, MSVD, and VATEX).

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arXiv2025

BronchOpt : Vision-Based Pose Optimization with Fine-Tuned Foundation Models for Accurate Bronchoscopy Navigation

Accurate intra-operative localization of the bronchoscope tip relative to patient anatomy remains challenging due to respiratory motion, anatomical variability, and CT-to-body divergence that cause deformation and misalignment between intra-operative views and pre-operative CT. Existing vision-based methods often fail to generalize across domains and patients, leading to residual alignment errors. This work establishes a generalizable foundation for bronchoscopy navigation through a robust vision-based framework and a new synthetic benchmark dataset that enables standardized and reproducible evaluation. We propose a vision-based pose optimization framework for frame-wise 2D-3D registration between intra-operative endoscopic views and pre-operative CT anatomy. A fine-tuned modality- and domain-invariant encoder enables direct similarity computation between real endoscopic RGB frames and CT-rendered depth maps, while a differentiable rendering module iteratively refines camera poses through depth consistency. To enhance reproducibility, we introduce the first public synthetic benchmark dataset for bronchoscopy navigation, addressing the lack of paired CT-endoscopy data. Trained exclusively on synthetic data distinct from the benchmark, our model achieves an average translational error of 2.65 mm and a rotational error of 0.19 rad, demonstrating accurate and stable localization. Qualitative results on real patient data further confirm strong cross-domain generalization, achieving consistent frame-wise 2D-3D alignment without domain-specific adaptation. Overall, the proposed framework achieves robust, domain-invariant localization through iterative vision-based optimization, while the new benchmark provides a foundation for standardized progress in vision-based bronchoscopy navigation.

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arXiv2025

DualVision ArthroNav: Investigating Opportunities to Enhance Localization and Reconstruction in Image-based Arthroscopy Navigation via External Cameras

Arthroscopic procedures can greatly benefit from navigation systems that enhance spatial awareness, depth perception, and field of view. However, existing optical tracking solutions impose strict workspace constraints and disrupt surgical workflow. Vision-based alternatives, though less invasive, often rely solely on the monocular arthroscope camera, making them prone to drift, scale ambiguity, and sensitivity to rapid motion or occlusion. We propose DualVision ArthroNav, a multi-camera arthroscopy navigation system that integrates an external camera rigidly mounted on the arthroscope. The external camera provides stable visual odometry and absolute localization, while the monocular arthroscope video enables dense scene reconstruction. By combining these complementary views, our system resolves the scale ambiguity and long-term drift inherent in monocular SLAM and ensures robust relocalization. Experiments demonstrate that our system effectively compensates for calibration errors, achieving an average absolute trajectory error of 1.09 mm. The reconstructed scenes reach an average target registration error of 2.16 mm, with high visual fidelity (SSIM = 0.69, PSNR = 22.19). These results indicate that our system provides a practical and cost-efficient solution for arthroscopic navigation, bridging the gap between optical tracking and purely vision-based systems, and paving the way toward clinically deployable, fully vision-based arthroscopic guidance.

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arXiv2025

Constrained Natural Language Action Planning for Resilient Embodied Systems

Replicating human-level intelligence in the execution of embodied tasks remains challenging due to the unconstrained nature of real-world environments. Novel use of large language models (LLMs) for task planning seeks to address the previously intractable state/action space of complex planning tasks, but hallucinations limit their reliability, and thus, viability beyond a research context. Additionally, the prompt engineering required to achieve adequate system performance lacks transparency, and thus, repeatability. In contrast to LLM planning, symbolic planning methods offer strong reliability and repeatability guarantees, but struggle to scale to the complexity and ambiguity of real-world tasks. We introduce a new robotic planning method that augments LLM planners with symbolic planning oversight to improve reliability and repeatability, and provide a transparent approach to defining hard constraints with considerably stronger clarity than traditional prompt engineering. Importantly, these augmentations preserve the reasoning capabilities of LLMs and retain impressive generalization in open-world environments. We demonstrate our approach in simulated and real-world environments. On the ALFWorld planning benchmark, our approach outperforms current state-of-the-art methods, achieving a near-perfect 99% success rate. Deployment of our method to a real-world quadruped robot resulted in 100% task success compared to 50% and 30% for pure LLM and symbolic planners across embodied pick and place tasks. Our approach presents an effective strategy to enhance the reliability, repeatability and transparency of LLM-based robot planners while retaining their key strengths: flexibility and generalizability to complex real-world environments. We hope that this work will contribute to the broad goal of building resilient embodied intelligent systems.

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arXiv2025

Causality-Driven Audits of Model Robustness

Robustness audits of deep neural networks (DNN) provide a means to uncover model sensitivities to the challenging real-world imaging conditions that significantly degrade DNN performance in-the-wild. Such conditions are often the result of multiple interacting factors inherent to the environment, sensor, or processing pipeline and may lead to complex image distortions that are not easily categorized. When robustness audits are limited to a set of isolated imaging effects or distortions, the results cannot be (easily) transferred to real-world conditions where image corruptions may be more complex or nuanced. To address this challenge, we present a new alternative robustness auditing method that uses causal inference to measure DNN sensitivities to the factors of the imaging process that cause complex distortions. Our approach uses causal models to explicitly encode assumptions about the domain-relevant factors and their interactions. Then, through extensive experiments on natural and rendered images across multiple vision tasks, we show that our approach reliably estimates causal effects of each factor on DNN performance using only observational domain data. These causal effects directly tie DNN sensitivities to observable properties of the imaging pipeline in the domain of interest towards reducing the risk of unexpected DNN failures when deployed in that domain.

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arXiv2025

A Causal Framework for Aligning Image Quality Metrics and Deep Neural Network Robustness

Image quality plays an important role in the performance of deep neural networks (DNNs) that have been widely shown to exhibit sensitivity to changes in imaging conditions. Conventional image quality assessment (IQA) seeks to measure and align quality relative to human perceptual judgments, but we often need a metric that is not only sensitive to imaging conditions but also well-aligned with DNN sensitivities. We first ask whether conventional IQA metrics are also informative of DNN performance. We show theoretically and empirically that conventional IQA metrics are weak predictors of DNN performance for image classification. Using our causal framework, we then develop metrics that exhibit strong correlation with DNN performance, thus enabling us to effectively estimate the quality distribution of large image datasets relative to targeted vision tasks.

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arXiv2025

Explainable AI for Automated User-specific Feedback in Surgical Skill Acquisition

Traditional surgical skill acquisition relies heavily on expert feedback, yet direct access is limited by faculty availability and variability in subjective assessments. While trainees can practice independently, the lack of personalized, objective, and quantitative feedback reduces the effectiveness of self-directed learning. Recent advances in computer vision and machine learning have enabled automated surgical skill assessment, demonstrating the feasibility of automatic competency evaluation. However, it is unclear whether such Artificial Intelligence (AI)-driven feedback can contribute to skill acquisition. Here, we examine the effectiveness of explainable AI (XAI)-generated feedback in surgical training through a human-AI study. We create a simulation-based training framework that utilizes XAI to analyze videos and extract surgical skill proxies related to primitive actions. Our intervention provides automated, user-specific feedback by comparing trainee performance to expert benchmarks and highlighting deviations from optimal execution through understandable proxies for actionable guidance. In a prospective user study with medical students, we compare the impact of XAI-guided feedback against traditional video-based coaching on task outcomes, cognitive load, and trainees' perceptions of AI-assisted learning. Results showed improved cognitive load and confidence post-intervention. While no differences emerged between the two feedback types in reducing performance gaps or practice adjustments, trends in the XAI group revealed desirable effects where participants more closely mimicked expert practice. This work encourages the study of explainable AI in surgical education and the development of data-driven, adaptive feedback mechanisms that could transform learning experiences and competency assessment.

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arXiv2025

Beyond Rigid AI: Towards Natural Human-Machine Symbiosis for Interoperative Surgical Assistance

Emerging surgical data science and robotics solutions, especially those designed to provide assistance in situ, require natural human-machine interfaces to fully unlock their potential in providing adaptive and intuitive aid. Contemporary AI-driven solutions remain inherently rigid, offering limited flexibility and restricting natural human-machine interaction in dynamic surgical environments. These solutions rely heavily on extensive task-specific pre-training, fixed object categories, and explicit manual-prompting. This work introduces a novel Perception Agent that leverages speech-integrated prompt-engineered large language models (LLMs), segment anything model (SAM), and any-point tracking foundation models to enable a more natural human-machine interaction in real-time intraoperative surgical assistance. Incorporating a memory repository and two novel mechanisms for segmenting unseen elements, Perception Agent offers the flexibility to segment both known and unseen elements in the surgical scene through intuitive interaction. Incorporating the ability to memorize novel elements for use in future surgeries, this work takes a marked step towards human-machine symbiosis in surgical procedures. Through quantitative analysis on a public dataset, we show that the performance of our agent is on par with considerably more labor-intensive manual-prompting strategies. Qualitatively, we show the flexibility of our agent in segmenting novel elements (instruments, phantom grafts, and gauze) in a custom-curated dataset. By offering natural human-machine interaction and overcoming rigidity, our Perception Agent potentially brings AI-based real-time assistance in dynamic surgical environments closer to reality.

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arXiv2025

Temporally-Constrained Video Reasoning Segmentation and Automated Benchmark Construction

Conventional approaches to video segmentation are confined to predefined object categories and cannot identify out-of-vocabulary objects, let alone objects that are not identified explicitly but only referred to implicitly in complex text queries. This shortcoming limits the utility for video segmentation in complex and variable scenarios, where a closed set of object categories is difficult to define and where users may not know the exact object category that will appear in the video. Such scenarios can arise in operating room video analysis, where different health systems may use different workflows and instrumentation, requiring flexible solutions for video analysis. Reasoning segmentation (RS) now offers promise towards such a solution, enabling natural language text queries as interaction for identifying object to segment. However, existing video RS formulation assume that target objects remain contextually relevant throughout entire video sequences. This assumption is inadequate for real-world scenarios in which objects of interest appear, disappear or change relevance dynamically based on temporal context, such as surgical instruments that become relevant only during specific procedural phases or anatomical structures that gain importance at particular moments during surgery. Our first contribution is the introduction of temporally-constrained video reasoning segmentation, a novel task formulation that requires models to implicitly infer when target objects become contextually relevant based on text queries that incorporate temporal reasoning. Since manual annotation of temporally-constrained video RS datasets would be expensive and limit scalability, our second contribution is an innovative automated benchmark construction method. Finally, we present TCVideoRSBenchmark, a temporally-constrained video RS dataset containing 52 samples using the videos from the MVOR dataset.

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arXiv2025

Privacy-Preserving Operating Room Workflow Analysis using Digital Twins

The operating room (OR) is a complex environment where optimizing workflows is critical to reduce costs and improve patient outcomes. While computer vision approaches for automatic recognition of perioperative events can identify bottlenecks for OR optimization, privacy concerns limit the use of OR videos for automated event detection. We propose a two-stage pipeline for privacy-preserving OR video analysis and event detection. First, we leverage vision foundation models for depth estimation and semantic segmentation to generate de-identified Digital Twins (DT) of the OR from conventional RGB videos. Second, we employ the SafeOR model, a fused two-stream approach that processes segmentation masks and depth maps for OR event detection. Evaluation on an internal dataset of 38 simulated surgical trials with five event classes shows that our DT-based approach achieves performance on par with -- and sometimes better than -- raw RGB video-based models for OR event detection. Digital Twins enable privacy-preserving OR workflow analysis, facilitating the sharing of de-identified data across institutions and potentially enhancing model generalizability by mitigating domain-specific appearance differences.

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arXiv2025

FluoroSAM: A Language-promptable Foundation Model for Flexible X-ray Image Segmentation

Language promptable X-ray image segmentation would enable greater flexibility for human-in-the-loop workflows in diagnostic and interventional precision medicine. Prior efforts have contributed task-specific models capable of solving problems within a narrow scope, but expanding to broader use requires additional data, annotations, and training time. Recently, language-aligned foundation models (LFMs) -- machine learning models trained on large amounts of highly variable image and text data thus enabling broad applicability -- have emerged as promising tools for automated image analysis. Existing foundation models for medical image analysis focus on scenarios and modalities where large, richly annotated datasets are available. However, the X-ray imaging modality features highly variable image appearance and applications, from diagnostic chest X-rays to interventional fluoroscopy, with varying availability of data. To pave the way toward an LFM for comprehensive and language-aligned analysis of arbitrary medical X-ray images, we introduce FluoroSAM, a language-promptable variant of the Segment Anything Model, trained from scratch on 3M synthetic X-ray images from a wide variety of human anatomies, imaging geometries, and viewing angles. These include pseudo-ground truth masks for 128 organ types and 464 tools with associated text descriptions. FluoroSAM is capable of segmenting myriad anatomical structures and tools based on natural language prompts, thanks to the novel incorporation of vector quantization (VQ) of text embeddings in the training process. We demonstrate FluoroSAM's performance quantitatively on real X-ray images and showcase on several applications how FluoroSAM is a key enabler for rich human-machine interaction in the X-ray image acquisition and analysis context. Code is available at https://github.com/arcadelab/fluorosam.

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