arXiv subjects

Matteo Cartiglia

Publications and source records attributed to Matteo Cartiglia.

9 recordsLinked to original sources

arXiv2026

Precise Positional Readout of Molecular Barcode Structures using Solid-State Nanopores

Fast and nonuniform translocation through solid-state nanopores limits both the detection of small molecular labels and their precise localization along molecular carriers. In this work we report the detection and localization performance of nucleotide-based molecular labels along double-stranded DNA scaffolds using solid-state nanopores in thin planar membranes. For small labels that are challenging to resolve individually, we introduce an anchoring strategy where readily detectable bulky labels serve as reference points to align multiple translocation events, enabling population-based detection and localization of smaller molecular features. The measured anchor positions constrain a probabilistic model of translocation velocity, identifying the most probable velocity profile for each event and enabling nonlinear trace "unwarping" for improved multi-event alignment. A complementary window-based evidence aggregation procedure accumulates weak but consistent label signatures across events, enabling detection of features that are individually masked by noise. These approaches enable robust recovery of single-dumbbell labels (DB1) on the order of 28 nucleotides and reduce mean localization errors to as low as 10 base pairs for DB3 labels and 40 base pairs for DB1 labels when averaging over multiple events. Stronger fractional DNA-associated current blockades, used as proxy for smaller pore geometries, are additionally associated with improved detection and lower localization error across membrane-based nanopore fabrication techniques. Overall, anchor-guided alignment provides a route to higher-density molecular information readout without compromising throughput via controlled translocation approaches.

q-bio.BM↗

arXiv2026

Latent space mapping of interpretable structural coordinates from stochastic single-molecule signals

Nanopores are versatile single-molecular sensors, but their utility is fundamentally constrained by stochastic translocation dynamics warping any encoded information. We resolve it by shifting from time-domain analysis to a learned latent-space mapping via a contrastive encoder trained exclusively on simulated signals from a physics-informed model. This encoder maps solid-state nanopore signals of engineered DNA barcodes into an interpretable molecular coordinate system. The learned representation is responsive to structural barcode parameters while remaining invariant to acquisition conditions and translocation conformation, allowing data pooling across devices. Molecule identification requires a single pass through the encoder, reducing computational cost by three orders of magnitude relative to alignment-based methods. We experimentally validate through mixture quantification, rare-variant detection, consensus barcode reconstruction, and real-time signal acquisition. This shift from temporal analysis to mapping structural coordinates into a latent space changes the paradigm behind analyzing stochastic sensor signals by linking classification to interpretable encoded molecular information.

physics.ins-det↗

arXiv2026

Data Sieving for Scalable Real-Time Multichannel Nanopore Sensing

High-throughput solid-state nanopore experiments generate continuous MHz-rate data streams in which only a small fraction of data contains informative molecular information. This creates storage and processing bottlenecks that limit experimental scalability. We introduce Data Sieving, a GPU-accelerated acquisition framework that integrates real-time event detection directly into the measurement pipeline and selectively stores and allows real-time analysis of snapshots around molecular translocations. The system employs a lightweight rolling-average and min-max trigger to identify event candidates in parallel across channels. This architecture reduces stored data volume by up to 98% while preserving complete molecular signatures across a wide temporal range, from microsecond-scale protein dynamics to second-scale nucleic acid nanoparticle events. Continuous baseline monitoring enables autonomous closed-loop actuation; in high-concentration DNA experiments, automatic declogging restored pore conductance, reducing the time spent in a non-productive clogged state to near-zero and without interrupting parallel measurements. Validated across DNA, protein, and nucleic acid nanoparticle measurements, Data Sieving links data storage directly to molecular information content rather than experiment duration, enabling scalable, real-time operation of parallel nanopore sensors. The approach provides a hardware-agnostic foundation for long-duration, high-bandwidth single-molecule experiments and other event-driven sensing platforms. By using algorithms intrinsically compatible with low-latency digital architectures, this framework provides a clear path toward high-bandwidth, highly multiplexed recording across hundreds of individual nanopore channels in both solid-state and biological pores.

physics.ins-det↗

arXiv2023

SPAIC: A sub-$μ$W/Channel, 16-Channel General-Purpose Event-Based Analog Front-End with Dual-Mode Encoders

Low-power event-based analog front-ends (AFE) are a crucial component required to build efficient end-to-end neuromorphic processing systems for edge computing. Although several neuromorphic chips have been developed for implementing spiking neural networks (SNNs) and solving a wide range of sensory processing tasks, there are only a few general-purpose analog front-end devices that can be used to convert analog sensory signals into spikes and interfaced to neuromorphic processors. In this work, we present a novel, highly configurable analog front-end chip, denoted as SPAIC (signal-to-spike converter for analog AI computation), that offers a general-purpose dual-mode analog signal-to-spike encoding with delta modulation and pulse frequency modulation, with tunable frequency bands. The ASIC is designed in a 180 nm process. It supports and encodes a wide variety of signals spanning 4 orders of magnitude in frequency, and provides an event-based output that is compatible with existing neuromorphic processors. We validated the ASIC for its functions and present initial silicon measurement results characterizing the basic building blocks of the chip.

cs.AR↗

arXiv2023

Neuromorphic analog circuits for robust on-chip always-on learning in spiking neural networks

Mixed-signal neuromorphic systems represent a promising solution for solving extreme-edge computing tasks without relying on external computing resources. Their spiking neural network circuits are optimized for processing sensory data on-line in continuous-time. However, their low precision and high variability can severely limit their performance. To address this issue and improve their robustness to inhomogeneities and noise in both their internal state variables and external input signals, we designed on-chip learning circuits with short-term analog dynamics and long-term tristate discretization mechanisms. An additional hysteretic stop-learning mechanism is included to improve stability and automatically disable weight updates when necessary, to enable continuous always-on learning. We designed a spiking neural network with these learning circuits in a prototype chip using a 180 nm CMOS technology. Simulation and silicon measurement results from the prototype chip are presented. These circuits enable the construction of large-scale spiking neural networks with online learning capabilities for real-world edge computing tasks.

cs.NE↗

arXiv2022

Spike-based local synaptic plasticity: A survey of computational models and neuromorphic circuits

Understanding how biological neural networks carry out learning using spike-based local plasticity mechanisms can lead to the development of powerful, energy-efficient, and adaptive neuromorphic processing systems. A large number of spike-based learning models have recently been proposed following different approaches. However, it is difficult to assess if and how they could be mapped onto neuromorphic hardware, and to compare their features and ease of implementation. To this end, in this survey, we provide a comprehensive overview of representative brain-inspired synaptic plasticity models and mixed-signal CMOS neuromorphic circuits within a unified framework. We review historical, bottom-up, and top-down approaches to modeling synaptic plasticity, and we identify computational primitives that can support low-latency and low-power hardware implementations of spike-based learning rules. We provide a common definition of a locality principle based on pre- and post-synaptic neuron information, which we propose as a fundamental requirement for physical implementations of synaptic plasticity. Based on this principle, we compare the properties of these models within the same framework, and describe the mixed-signal electronic circuits that implement their computing primitives, pointing out how these building blocks enable efficient on-chip and online learning in neuromorphic processing systems.

cs.NE↗

arXiv2022

Stochastic dendrites enable online learning in mixed-signal neuromorphic processing systems

The stringent memory and power constraints required in edge-computing sensory-processing applications have made event-driven neuromorphic systems a promising technology. On-chip online learning provides such systems the ability to learn the statistics of the incoming data and to adapt to their changes. Implementing online learning on event driven-neuromorphic systems requires (i) a spike-based learning algorithm that calculates the weight updates using only local information from streaming data, (ii) mapping these weight updates onto limited bit precision memory and (iii) doing so in a robust manner that does not lead to unnecessary updates as the system is reaching its optimal output. Recent neuroscience studies have shown how dendritic compartments of cortical neurons can solve these problems in biological neural networks. Inspired by these studies we propose spike-based learning circuits to implement stochastic dendritic online learning. The circuits are embedded in a prototype spiking neural network fabricated using a 180nm process. Following an algorithm-circuits co-design approach we present circuits and behavioral simulation results that demonstrate the learning rule features. We validate the proposed method using behavioral simulations of a single-layer network with 4-bit precision weights applied to the MNIST benchmark and demonstrating results that reach accuracy levels above 85%.

cs.ET↗

arXiv2021

Online Detection of Vibration Anomalies Using Balanced Spiking Neural Networks

Vibration patterns yield valuable information about the health state of a running machine, which is commonly exploited in predictive maintenance tasks for large industrial systems. However, the overhead, in terms of size, complexity and power budget, required by classical methods to exploit this information is often prohibitive for smaller-scale applications such as autonomous cars, drones or robotics. Here we propose a neuromorphic approach to perform vibration analysis using spiking neural networks that can be applied to a wide range of scenarios. We present a spike-based end-to-end pipeline able to detect system anomalies from vibration data, using building blocks that are compatible with analog-digital neuromorphic circuits. This pipeline operates in an online unsupervised fashion, and relies on a cochlea model, on feedback adaptation and on a balanced spiking neural network. We show that the proposed method achieves state-of-the-art performance or better against two publicly available data sets. Further, we demonstrate a working proof-of-concept implemented on an asynchronous neuromorphic processor device. This work represents a significant step towards the design and implementation of autonomous low-power edge-computing devices for online vibration monitoring.

cs.NE↗

arXiv2021

An error-propagation spiking neural network compatible with neuromorphic processors

Spiking neural networks have shown great promise for the design of low-power sensory-processing and edge-computing hardware platforms. However, implementing on-chip learning algorithms on such architectures is still an open challenge, especially for multi-layer networks that rely on the back-propagation algorithm. In this paper, we present a spike-based learning method that approximates back-propagation using local weight update mechanisms and which is compatible with mixed-signal analog/digital neuromorphic circuits. We introduce a network architecture that enables synaptic weight update mechanisms to back-propagate error signals across layers and present a network that can be trained to distinguish between two spike-based patterns that have identical mean firing rates, but different spike-timings. This work represents a first step towards the design of ultra-low power mixed-signal neuromorphic processing systems with on-chip learning circuits that can be trained to recognize different spatio-temporal patterns of spiking activity (e.g. produced by event-based vision or auditory sensors).

cs.NE↗