arXiv subjects

Matteo Morciano

Publications and source records attributed to Matteo Morciano.

2 recordsLinked to original sources

arXiv2024

Pore-level Quantitative Structure-Activity Relationship (QSAR) for Water Permeation Rate in Aquaporins

Aquaporins (AQPs) and aquaglyceroporins (AQGPs) play a crucial role in regulating water transport and solute selectivity across biological membranes. Besides their biological relevance, AQPs have at-tracted growing interest as models for the design of next-generation biomimetic membranes for water filtration. In this work, we present a pore-level Quantitative Structure-Activity Relationship (QSAR) approach that relates structural and physicochemical pore descriptors with experimentally reported water permeation rates across a set of AQ(G)Ps with high-resolution 3D structures. This data-driven methodology, presented here as a proof of concept, introduces a multi-feature framework for determining pore descriptors associated with water transport efficiency in AQ(G)Ps. Applied to two compiled permeation rate datasets, this framework recapitulates determinants previously reported in single-feature studies, while also highlighting additional pore descriptors that emerge as relevant in a multi-variable context. The insights gained through this approach may, in perspective, contribute to advancing the rational design of AQP-based filtration devices and to deepening the molecular understanding of the function of these valuable macromolecules in health and disease.

q-bio.BM↗

arXiv2017

Passive high-yield seawater desalination at below one sun by modular and low-cost distillation

Although seawater is abundant, desalination is energy-intensive and expensive. Using the sun as an energy source is attractive for desalinating seawater; however, the performance of state-of-the-art passive devices is unsatisfactory when operated at less than one sun ($<$ $1$ $kW$ $m^{-2}$). Here, we present a completely passive, modular, and low-cost solar thermal distiller for seawater desalination. Each distillation stage is made of two opposed hydrophilic layers separated by a hydrophobic microporous membrane, and it does not require further mechanical ancillaries. Under realistic laboratory and outdoor conditions, we obtained a distillate flow rate of almost $3$ $L$ $m^{-2}$ $h^{-1}$ from seawater at less than one sun - twice the yield of recent passive device reported in the literature. In perspective, theoretical modelling suggests that the distiller has the potential to further doubling the peak flow rate observed in the current experiments. This layout can satisfy freshwater needs in isolated and impoverished communities, as well as realize self-sufficient floating installations or provide freshwater in emergency conditions.

cond-mat.other↗