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Matthew Moores

Publications and source records attributed to Matthew Moores.

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Efficient Amortized Bayesian Inference for Markov Random Fields via Gradient-Informed Grid Selection

Bayesian inference for models with intractable likelihoods, such as Markov random fields, poses a fundamental computational challenge due to the tradeoff between inferential accuracy and computational cost. Various MCMC methods have been developed to address this challenge. The exchange algorithm targets the exact posterior, but requires an expensive perfect sampling step at each iteration, which is often infeasible in practice. In contrast, path sampling approximates the Metropolis acceptance ratio using a precomputed grid of likelihood values, but may introduce bias when the grid is poorly chosen. We introduce a novel amortized MCMC framework that retains the theoretical validity of exact methods while substantially reducing the computational burden. The proposed approach employs a gradient-informed grid selection procedure and constructs a surrogate likelihood via Hermite interpolation, yielding a smooth approximation with low error. A simulation study characterizes the rate at which inferential accuracy improves as the number of grid points increases. We further demonstrate the practical performance of the method through applications to a hidden Potts model for satellite imagery and an autologistic model for Arctic ice floes.

stat.ME

Bayesian modelling and quantification of Raman spectroscopy

Raman spectroscopy can be used to identify molecules such as DNA by the characteristic scattering of light from a laser. It is sensitive at very low concentrations and can accurately quantify the amount of a given molecule in a sample. The presence of a large, nonuniform background presents a major challenge to analysis of these spectra. To overcome this challenge, we introduce a sequential Monte Carlo (SMC) algorithm to separate the observed spectrum into a series of peaks plus a smoothly-varying baseline, corrupted by additive white noise. The peaks are modelled using Lorentzian or Gaussian broadening functions, while the baseline is estimated using a penalised cubic spline. This latent continuous representation accounts for differences in resolution between measurements. By incorporating this representation in a Bayesian model, we can quantify the relationship between molecular concentration and peak intensity, thereby providing an improved estimate of the limit of detection (LOD), which is of major importance in analytical chemistry.

stat.AP