arXiv subjects

Matthieu Marbac

Publications and source records attributed to Matthieu Marbac.

21 records · Page 2Linked to original sources

arXiv2015

Bayesian model selection in logistic regression for the detection of adverse drug reactions

Motivation: Spontaneous adverse event reports have a high potential for detecting adverse drug reactions. However, due to their dimension, exploring such databases requires statistical methods. In this context, disproportionality measures are used. However, by projecting the data onto contingency tables, these methods become sensitive to the problem of co-prescriptions and masking effects. Recently, logistic regressions have been used with a Lasso type penalty to perform the detection of associations between drugs and adverse events. However, the choice of the penalty value is open to criticism while it strongly influences the results. Results: In this paper, we propose to use a logistic regression whose sparsity is viewed as a model selection challenge. Since the model space is huge, a Metropolis-Hastings algorithm carries out the model selection by maximizing the BIC criterion. Thus, we avoid the calibration of penalty or threshold. During our application on the French pharmacovigilance database, the proposed method is compared to well established approaches on a reference data set, and obtains better rates of positive and negative controls. However, many signals are not detected by the proposed method. So, we conclude that this method should be used in parallel to existing measures in pharmacovigilance.

stat.AP↗

arXiv2014

Model-based clustering for conditionally correlated categorical data

An extension of the latent class model is presented for clustering categorical data by relaxing the classical "class conditional independence assumption" of variables. This model consists in grouping the variables into inter-independent and intra-dependent blocks, in order to consider the main intra-class correlations. The dependency between variables grouped inside the same block of a class is taken into account by mixing two extreme distributions, which are respectively the independence and the maximum dependency. When the variables are dependent given the class, this approach is expected to reduce the biases of the latent class model. Indeed, it produces a meaningful dependency model with only a few additional parameters. The parameters are estimated, by maximum likelihood, by means of an EM algorithm. Moreover, a Gibbs sampler is used for model selection in order to overcome the computational intractability of the combinatorial problems involved by the block structure search. Two applications on medical and biological data sets show the relevance of this new model. The results strengthen the view that this model is meaningful and that it reduces the biases induced by the conditional independence assumption of the latent class model.

stat.CO↗

arXiv2014

Finite mixture model of conditional dependencies modes to cluster categorical data

We propose a parsimonious extension of the classical latent class model to cluster categorical data by relaxing the class conditional independence assumption. Under this new mixture model, named Conditional Modes Model, variables are grouped into conditionally independent blocks. The corresponding block distribution is a parsimonious multinomial distribution where the few free parameters correspond to the most likely modality crossings, while the remaining probability mass is uniformly spread over the other modality crossings. Thus, the proposed model allows to bring out the intra-class dependency between variables and to summarize each class by a few characteristic modality crossings. The model selection is performed via a Metropolis-within-Gibbs sampler to overcome the computational intractability of the block structure search. As this approach involves the computation of the integrated complete-data likelihood, we propose a new method (exact for the continuous parameters and approximated for the discrete ones) which avoids the biases of the \textsc{bic} criterion pointed out by our experiments. Finally, the parameters are only estimated for the best model via an \textsc{em} algorithm. The characteristics of the new model are illustrated on simulated data and on two biological data sets. These results strengthen the idea that this simple model allows to reduce biases involved by the conditional independence assumption and gives meaningful parameters. Both applications were performed with the R package \texttt{CoModes}

stat.ME↗