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Megan L. Gelsinger

Publications and source records attributed to Megan L. Gelsinger.

2 recordsLinked to original sources

Log-Gaussian Cox Process Modeling of Large Spatial Lightning Data using Spectral and Laplace Approximations

Lightning is a destructive and highly visible product of severe storms, yet there is still much to be learned about the conditions under which lightning is most likely to occur. The GOES-16 and GOES-17 satellites, launched in 2016 and 2018 by NOAA and NASA, collect a wealth of data regarding individual lightning strike occurrence and potentially related atmospheric variables. The acute nature and inherent spatial correlation in lightning data renders standard regression analyses inappropriate. Further, computational considerations are foregrounded by the desire to analyze the immense and rapidly increasing volume of lightning data. We present a new computationally feasible method that combines spectral and Laplace approximations in an EM algorithm, denoted SLEM, to fit the widely popular log-Gaussian Cox process model to large spatial point pattern datasets. In simulations, we find SLEM is competitive with contemporary techniques in terms of speed and accuracy. When applied to two lightning datasets, SLEM provides better out-of-sample prediction scores and quicker runtimes, suggesting its particular usefulness for analyzing lightning data, which tend to have sparse signals.

stat.AP

Cell Line Classification Using Electric Cell-substrate Impedance Sensing (ECIS)

We consider cell line classification using multivariate time series data obtained from electric cell-substrate impedance sensing (ECIS) technology. The ECIS device, which monitors the attachment and spreading of mammalian cells in real time through the collection of electrical impedance data, has historically been used to study one cell line at a time. However, we show that if applied to data from multiple cell lines, ECIS can be used to classify unknown or potentially mislabeled cells, which may help to mitigate the current crisis of reproducibility in the biological literature. We assess a range of approaches to this new problem, testing different classification methods and deriving a dictionary of 29 features to characterize ECIS data. Our analysis also makes use of simultaneous multi-frequency ECIS data, where previous studies have focused on only one frequency. In classification tests on fifteen mammalian cell lines, we obtain very high out-of-sample accuracy. These preliminary findings provide a baseline for future large-scale studies in this field.

q-bio.QM