arXiv subjects

Mehdi Hosseinzadeh

Publications and source records attributed to Mehdi Hosseinzadeh.

At least 19 recordsLinked to original sources

arXiv2026

Transcriptomic Models for Immunotherapy Response Prediction Show Limited Cross-cohort Generalisability

Immune checkpoint inhibitors (ICIs) have transformed cancer therapy; yet substantial proportion of patients exhibit intrinsic or acquired resistance, making accurate pre-treatment response prediction a critical unmet need. Transcriptomics-based biomarkers derived from bulk and single-cell RNA sequencing (scRNA-seq) offer a promising avenue for capturing tumour-immune interactions, yet the cross-cohort generalisability of existing prediction models remains unclear.We systematically benchmark nine state-of-the-art transcriptomic ICI response predictors, five bulk RNA-seq-based models (COMPASS, IRNet, NetBio, IKCScore, and TNBC-ICI) and four scRNA-seq-based models (PRECISE, DeepGeneX, Tres and scCURE), using publicly available independent datasets unseen during model development. Overall, predictive performance was modest: bulk RNA-seq models performed at or near chance level across most cohorts, while scRNA-seq models showed only marginal improvements. Pathway-level analyses revealed sparse and inconsistent biomarker signals across models. Although scRNA-seq-based predictors converged on immune-related programs such as allograft rejection, bulk RNA-seq-based models exhibited little reproducible overlap. PRECISE and NetBio identified the most coherent immune-related themes, whereas IRNet predominantly captured metabolic pathways weakly aligned with ICI biology. Together, these findings demonstrate the limited cross-cohort robustness and biological consistency of current transcriptomic ICI prediction models, underscoring the need for improved domain adaptation, standardised preprocessing, and biologically grounded model design.

q-bio.GN↗

arXiv2026

ProTracer: Proprioception-Guided Failure Diagnosis in Robot Manipulation

This paper presents a comprehensive framework for robot manipulation failure analysis that includes binary failure detection, failure categorization, explanation generation, and the additional capability of failure onset localization, which aims to identify the earliest moment at which a robot execution deviates from a valid task-completion trajectory and is ultimately followed by task failure. To address these tasks, we propose ProTracer, a training-free framework that leverages existing Vision-Language Models (VLMs) together with proprioceptive signals for failure analysis. Our method uses proprioceptive dynamics to identify temporally informative action boundaries and converts richer robot-state signals into structured natural-language descriptions that can be jointly analyzed together with visual observations by the VLM. This design combines the temporal precision of proprioceptive signals with the multimodal reasoning capabilities of modern VLMs without requiring additional model training. We further introduce FailTime, a benchmark with synchronized visual and proprioceptive observations for evaluating conventional failure diagnosis tasks as well as failure onset localization. Experiments demonstrate that ProTracer achieves strong performance across both conventional failure diagnosis tasks and the newly introduced failure onset localization task, highlighting the importance of proprioceptive reasoning for fine-grained temporal failure analysis.

cs.RO↗

arXiv2026

A Q-learning-based QoS-aware multipath routing protocol in IoMT-based wireless body area network

The Internet of Medical Things (IoMT) enables intelligent healthcare services but faces challenges such as dynamic topology, energy constraints, and diverse QoS requirements. This paper proposes QQMR, a Q-learning-based QoS-aware multipath routing method for WBANs. QQMR classifies data into three priority levels and employs adaptive multi-level queuing and fuzzy C-means clustering to optimize routing decisions. It maintains separate learning policies for each data type and selects primary and backup paths accordingly. Experimental results demonstrate improved packet delivery ratio and significant reductions in delay, routing overhead, and energy consumption compared to existing methods.

cs.NI↗

arXiv2026

Gradient Under Microscope: Benchmarking Resource Utilization of Memory-Efficient Gradient Computation Methods

AI training's rising resource intensity is straining electricity supplies and carbon budgets, motivating systematic study of memory-efficient training on constrained hardware. We benchmark five gradient optimizers (SGD, Adam, Adagrad, Adadelta, and Conjugate Gradient Descent) under three memory strategies (standard training, gradient checkpointing, and gradient accumulation) across four transformer architectures (ViT, ModernBERT, Llama 3.1 1B, and NanoVLM), measuring training loss, GPU utilization, training time, and memory usage. Gradient accumulation emerges as the most reliable strategy, cutting training loss by roughly an order of magnitude on the vision-language model and about four-fold on the language model without additional GPU memory. Contrary to common practice, Adam is not universally superior: Adadelta and SGD outperform it on the encoder and autoregressive architectures. Gradient checkpointing's effect is strongly architecture-dependent, improving vision transformer loss while severely degrading the encoder model, and it increases training time by up to 60% on memory-bound models. GPU utilization is governed primarily by architecture, ranging from 8-15% for the memory-bound language model to 96-99% for compute-bound vision models. These findings provide practical guidelines for optimizer and gradient-strategy selection in resource-efficient model training and deployment.

cs.LG↗

arXiv2026

G3Splat: Geometrically Consistent Generalizable Gaussian Splatting

3D Gaussians have become a powerful scene representation for real-time splatting and high-quality novel-view synthesis. This has motivated generalizable splatting -- methods that adapt feed-forward geometry prediction networks to produce per-pixel Gaussians from a set of images. However, most generalizable splatting pipelines are supervised primarily through a view-synthesis loss to predict Gaussian orientation, anisotropic scale, opacity, and appearance in addition to their locations. We show that this learning objective is under-constrained. Models trained with view synthesis alone produce splats whose orientations and scales have no geometric connotation. The result is that, while producing decent view-synthesis performance, nearly all generalizable splatting methods produce geometrically inaccurate and misaligned Gaussians. We introduce G3Splat, a geometry-consistent generalizable splatting framework that addresses these degeneracies through differentiable geometric priors on the predicted 3D Gaussians, making the learning problem well-posed. These priors encourage the per-pixel splats to remain on their viewing rays and to orient themselves in accordance with local surfaces. Our priors are architecture-agnostic and can be incorporated into any previously studied geometric backbone for generalizable splatting, as well as different scene representations. We test G3Splat with both DUSt3R-style and VGGT-style backbones to predict pixel-aligned full-rank 3DGS as well as surfel-like 2DGS. Trained on RE10K, G3Splat produces Gaussian splats with significantly higher geometric fidelity than baselines, providing state-of-the-art novel-view depth, mesh reconstruction, and relative pose estimation performance while preserving novel-view synthesis quality, as evaluated on datasets such as ACID and ScanNet. Code and pretrained models are released on our project page.

cs.CV↗

arXiv2026

PriPG-RL: Privileged Planner-Guided Reinforcement Learning for Partially Observable Systems with Anytime-Feasible MPC

This paper addresses the problem of training a reinforcement learning (RL) policy under partial observability by exploiting a privileged, anytime-feasible planner agent available exclusively during training. We formalize this as a Partially Observable Markov Decision Process (POMDP) in which a planner agent with access to an approximate dynamical model and privileged state information guides a learning agent that observes only a lossy projection of the true state. To realize this framework, we introduce an anytime-feasible Model Predictive Control (MPC) algorithm that serves as the planner agent. For the learning agent, we propose Planner-to-Policy Soft Actor-Critic (P2P-SAC), a method that distills the planner agent's privileged knowledge to mitigate partial observability and thereby improve both sample efficiency and final policy performance. We support this framework with rigorous theoretical analysis. Finally, we validate our approach in simulation using NVIDIA Isaac Lab and successfully deploy it on a real-world Unitree Go2 quadruped navigating complex, obstacle-rich environments.

cs.LG↗

arXiv2026

KITE: Keyframe-Indexed Tokenized Evidence for VLM-Based Robot Failure Analysis

We present KITE, a training-free, keyframe-anchored, layout-grounded front-end that converts long robot-execution videos into compact, interpretable tokenized evidence for vision-language models (VLMs). KITE distills each trajectory into a small set of motion-salient keyframes with open-vocabulary detections and pairs each keyframe with a schematic bird's-eye-view (BEV) representation that encodes relative object layout, axes, timestamps, and detection confidence. These visual cues are serialized with robot-profile and scene-context tokens into a unified prompt, allowing the same front-end to support failure detection, identification, localization, explanation, and correction with an off-the-shelf VLM. On the RoboFAC benchmark, KITE with Qwen2.5-VL substantially improves over vanilla Qwen2.5-VL in the training-free setting, with especially large gains on simulation failure detection, identification, and localization, while remaining competitive with a RoboFAC-tuned baseline. A small QLoRA fine-tune further improves explanation and correction quality. We also report qualitative results on real dual-arm robots, demonstrating the practical applicability of KITE as a structured and interpretable front-end for robot failure analysis. Code and models are released on our project page: https://m80hz.github.io/kite/

cs.RO↗

arXiv2026

A Physical Agentic Loop for Language-Guided Grasping with Execution-State Monitoring

Robotic manipulation systems that follow language instructions often execute grasp primitives in a largely single-shot manner: a model proposes an action, the robot executes it, and failures such as empty grasps, slips, stalls, timeouts, or semantically wrong grasps are not surfaced to the decision layer in a structured way. Inspired by agentic loops in digital tool-using agents, we reformulate language-guided grasping as a bounded embodied agent operating over grounded execution states, where physical actions expose an explicit tool-state stream. We introduce a physical agentic loop that wraps an unmodified learned manipulation primitive (grasp-and-lift) with (i) an event-based interface and (ii) an execution monitoring layer, Watchdog, which converts noisy gripper telemetry into discrete outcome labels using contact-aware fusion and temporal stabilization. These outcome events, optionally combined with post-grasp semantic verification, are consumed by a deterministic bounded policy that finalizes, retries, or escalates to the user for clarification, guaranteeing finite termination. We validate the resulting loop on a mobile manipulator with an eye-in-hand D405 camera, keeping the underlying grasp model unchanged and evaluating representative scenarios involving visual ambiguity, distractors, and induced execution failures. Results show that explicit execution-state monitoring and bounded recovery enable more robust and interpretable behavior than open-loop execution, while adding minimal architectural overhead. For the source code and demo refer to our project page: https://wenzewwz123.github.io/Agentic-Loop/

cs.RO↗

arXiv2026

A Block-Alternating Iterative Approach for a Class of Non-Convex Optimization Problems

Constrained non-convex optimization problems frequently arise in control applications. Solving such problems is inherently challenging, as existing methods often converge to suboptimal local minima or incur prohibitive computational costs. To address this challenge, this paper proposes a novel block-alternating iterative method that decomposes the original problem into variable-specific subproblems, which are solved iteratively. Under the assumption that the problem is convex with respect to each decision variable, the proposed approach reformulates the original problem into a sequence of convex subproblems. Theoretical results are established regarding the convergence and optimality of the method. In addition, a numerical example and a real-world control engineering application are presented to demonstrate its effectiveness. Finally, this paper introduces a ready-to-use Python platform that implements the proposed method, together with existing algorithms, to facilitate comparison and adoption.

math.OC↗

arXiv2025

An Adaptive Method for Contextual Stochastic Multi-armed Bandits with Rewards Generated by a Linear Dynamical System

Online decision-making can be formulated as the popular stochastic multi-armed bandit problem where a learner makes decisions (or takes actions) to maximize cumulative rewards collected from an unknown environment. This paper proposes to model a stochastic multi-armed bandit as an unknown linear Gaussian dynamical system, as many applications, such as bandits for dynamic pricing problems or hyperparameter selection for machine learning models, can benefit from this perspective. Following this approach, we can build a matrix representation of the system's steady-state Kalman filter that takes a set of previously collected observations from a time interval of length $s$ to predict the next reward that will be returned for each action. This paper proposes a solution in which the parameter $s$ is determined via an adaptive algorithm by analyzing the model uncertainty of the matrix representation. This algorithm helps the learner adaptively adjust its model size and its length of exploration based on the uncertainty of its environmental model. The effectiveness of the proposed scheme is demonstrated through extensive numerical studies, revealing that the proposed scheme is capable of increasing the rate of collected cumulative rewards.

eess.SY↗

arXiv2025

Pruning and Quantization Impact on Graph Neural Networks

Graph neural networks (GNNs) are known to operate with high accuracy on learning from graph-structured data, but they suffer from high computational and resource costs. Neural network compression methods are used to reduce the model size while maintaining reasonable accuracy. Two of the common neural network compression techniques include pruning and quantization. In this research, we empirically examine the effects of three pruning methods and three quantization methods on different GNN models, including graph classification tasks, node classification tasks, and link prediction. We conducted all experiments on three graph datasets, including Cora, Proteins, and BBBP. Our findings demonstrate that unstructured fine-grained and global pruning can significantly reduce the model's size(50\%) while maintaining or even improving precision after fine-tuning the pruned model. The evaluation of different quantization methods on GNN shows diverse impacts on accuracy, inference time, and model size across different datasets.

cs.LG↗

arXiv2025

GradES: Significantly Faster Training in Transformers with Gradient-Based Early Stopping

Early stopping monitors global validation loss and halts all parameter updates simultaneously, which is computationally costly for large transformers due to the extended time required for validation inference. We propose \textit{GradES}, a novel gradient-based early stopping approach that operates within transformer components (attention projections and Feed-Forward layer matrices). We found that different components converge at varying rates during fine-tuning for both language and vision-language models. \textit{GradES} tracks the magnitude of gradient changes in backpropagation for these matrices during training. When a projection matrix's magnitude of gradient changes fall below a convergence threshold $τ$, we exclude that projection matrix from further updates individually, eliminating costly validation passes while allowing slow converging matrices to continue learning. \textit{GradES} speeds up training time by 1.57--7.22$\times$ while simultaneously enhancing generalization through early prevention of overfitting, resulting in 1.2\% higher average accuracy in language tasks and 3.88\% on multimodal benchmarks.

cs.LG↗

arXiv2025

TANGO: Traversability-Aware Navigation with Local Metric Control for Topological Goals

Visual navigation in robotics traditionally relies on globally-consistent 3D maps or learned controllers, which can be computationally expensive and difficult to generalize across diverse environments. In this work, we present a novel RGB-only, object-level topometric navigation pipeline that enables zero-shot, long-horizon robot navigation without requiring 3D maps or pre-trained controllers. Our approach integrates global topological path planning with local metric trajectory control, allowing the robot to navigate towards object-level sub-goals while avoiding obstacles. We address key limitations of previous methods by continuously predicting local trajectory using monocular depth and traversability estimation, and incorporating an auto-switching mechanism that falls back to a baseline controller when necessary. The system operates using foundational models, ensuring open-set applicability without the need for domain-specific fine-tuning. We demonstrate the effectiveness of our method in both simulated environments and real-world tests, highlighting its robustness and deployability. Our approach outperforms existing state-of-the-art methods, offering a more adaptable and effective solution for visual navigation in open-set environments. The source code is made publicly available: https://github.com/podgorki/TANGO.

cs.RO↗

arXiv2025

TinyMusician: On-Device Music Generation with Knowledge Distillation and Mixed Precision Quantization

The success of the generative model has gained unprecedented attention in the music generation area. Transformer-based architectures have set new benchmarks for model performance. However, their practical adoption is hindered by some critical challenges: the demand for massive computational resources and inference time, due to their large number of parameters. These obstacles make them infeasible to deploy on edge devices, such as smartphones and wearables, with limited computational resources. In this work, we present TinyMusician, a lightweight music generation model distilled from MusicGen (a State-of-the-art music generation model). TinyMusician integrates two innovations: (i) Stage-mixed Bidirectional and Skewed KL-Divergence and (ii) Adaptive Mixed-Precision Quantization. The experimental results demonstrate that TinyMusician retains 93% of the MusicGen-Small performance with 55% less model size. TinyMusician is the first mobile-deployable music generation model that eliminates cloud dependency while maintaining high audio fidelity and efficient resource usage

cs.SD↗

arXiv2025

Safe and Efficient Robot Action Planning in the Presence of Unconcerned Humans

This paper proposes a robot action planning scheme that provides an efficient and probabilistically safe plan for a robot interacting with an unconcerned human -- someone who is either unaware of the robot's presence or unwilling to engage in ensuring safety. The proposed scheme is predictive, meaning that the robot is required to predict human actions over a finite future horizon; such predictions are often inaccurate in real-world scenarios. One possible approach to reduce the uncertainties is to provide the robot with the capability of reasoning about the human's awareness of potential dangers. This paper discusses that by using a binary variable, so-called danger awareness coefficient, it is possible to differentiate between concerned and unconcerned humans, and provides a learning algorithm to determine this coefficient by observing human actions. Moreover, this paper argues how humans rely on predictions of other agents' future actions (including those of robots in human-robot interaction) in their decision-making. It also shows that ignoring this aspect in predicting human's future actions can significantly degrade the efficiency of the interaction, causing agents to deviate from their optimal paths. The proposed robot action planning scheme is verified and validated via extensive simulation and experimental studies on a LoCoBot WidowX-250.

cs.RO↗

arXiv2025

REAP-T: A MATLAB Toolbox for Implementing Robust-to-Early Termination Model Predictive Control

This paper presents a MATLAB toolbox for implementing robust-to-early termination model predictive control, abbreviated as REAP, which is designed to ensure a sub-optimal yet feasible solution when MPC computations are prematurely terminated due to limited computational resources. Named REAP-T, this toolbox is a comprehensive, user-friendly, and modular platform that enables users to explore, analyze, and customize various components of REAP for their specific applications. Notable attributes of REAP-T are: (i) utilization of built-in MATLAB functions for defining the MPC problem; (ii) an interactive and intuitive graphical user interface for parameter tuning and visualization; (iii) real-time simulation capabilities, allowing users to observe and understand the real-time behavior of their systems; and (iv) inclusion of real-world examples designed to guide users through its effective use.

math.OC↗

arXiv2025

Uncertainty-Guided Self-Questioning and Answering for Video-Language Alignment

The development of multi-modal models has been rapidly advancing, with some demonstrating remarkable capabilities. However, annotating video-text pairs remains expensive and insufficient. Take video question answering (VideoQA) tasks as an example, human annotated questions and answers often cover only part of the video, since the corresponding text is often short and monotonous, leading to underutilization of video. To address this, we propose a Bootstrapping Video-Language Alignment framework (BoViLA), a self-training method that augments question samples during training process through LLM-based self-questioning and answering, which help model exploit video information and the internal knowledge of LLMs more thoroughly to improve modality alignment. However, low-quality self-generated questions may instead contaminate the performance, especially in the early stages of training, as we have observed in our experiments. To filter bad self-generated questions, we introduce Evidential Deep Learning (EDL) to estimate uncertainty and assess the quality of self-generated questions by evaluating the modality alignment within the context. To the best of our knowledge, this work is the first to explore LLM-based self-training frameworks for modality alignment. We evaluate BoViLA on five strong VideoQA benchmarks, where it outperforms several state-of-the-art methods and demonstrate its effectiveness and generality. Additionally, we provide extensive analyses of the self-training framework and the EDL-based uncertainty filtering mechanism. The code will be made available.

cs.CV↗

arXiv2025

Robust Steady-State-Aware Model Predictive Control for Systems with Limited Computational Resources and External Disturbances

Model Predictive Control (MPC) is a powerful control strategy; however, its reliance on online optimization poses significant challenges for implementation on systems with limited computational resources. One possible approach to address this issue is to shorten the prediction horizon and adjust the conventional MPC formulation to enlarge the region of attraction. However, these methods typically introduce additional computational load. Recently, steady-state-aware MPC has been introduced to ensure output tracking and convergence to a given desired steady-state configuration while maintaining constraint satisfaction at all times without adding extra computational load. Despite its promising performance, steady-state-aware MPC does not account for external disturbances, which can significantly limit its applicability to real-world systems. This paper aims to advance the method further by enhancing its robustness against external disturbances. To achieve this, we adopt the tube-based design framework, which decouples nominal trajectory optimization from robust control synthesis, thereby requiring no additional online computational resources. Theoretical guarantees of the proposed methodology are shown analytically, and its effectiveness is assessed through simulations and experimental studies on a Parrot Bebop 2 drone.

math.OC↗