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Melvin McInnis

Publications and source records attributed to Melvin McInnis.

4 recordsLinked to original sources

A Time-Varying and Covariate-Dependent Correlation Model for Multivariate Longitudinal Studies

In multivariate longitudinal studies, associations between outcomes often exhibit time-varying and individual level heterogeneity, motivating the modeling of correlations as an explicit function of time and covariates. However, most existing methods for correlation analysis fail to simultaneously capture the time-varying and covariate-dependent effects. We propose a Time-Varying and Covariate-Dependent (TiVAC) correlation model that jointly allows covariate effects on correlation to change flexibly and smoothly across time. TiVAC employs a bivariate Gaussian model where the covariate-dependent correlations are modeled semiparametrically using penalized splines. We develop a penalized maximum likelihood-based Newton-Raphson algorithm, and inference on time-varying effects is provided through simultaneous confidence bands. Simulation studies show that TiVAC consistently outperforms existing methods in accurately estimating correlations across a wide range of settings, including binary and continuous covariates, sparse to dense observation schedules, and across diverse correlation trajectory patterns. We apply TiVAC to a psychiatric case study of 291 bipolar I patients, modeling the time-varying correlation between depression and anxiety scores as a function of their clinical variables. Our analyses reveal significant heterogeneity associated with gender and nervous-system medication use, which varies with age, revealing the complex dynamic relationship between depression and anxiety in bipolar disorders.

stat.ME

Identifying Mood Episodes Using Dialogue Features from Clinical Interviews

Bipolar disorder, a severe chronic mental illness characterized by pathological mood swings from depression to mania, requires ongoing symptom severity tracking to both guide and measure treatments that are critical for maintaining long-term health. Mental health professionals assess symptom severity through semi-structured clinical interviews. During these interviews, they observe their patients' spoken behaviors, including both what the patients say and how they say it. In this work, we move beyond acoustic and lexical information, investigating how higher-level interactive patterns also change during mood episodes. We then perform a secondary analysis, asking if these interactive patterns, measured through dialogue features, can be used in conjunction with acoustic features to automatically recognize mood episodes. Our results show that it is beneficial to consider dialogue features when analyzing and building automated systems for predicting and monitoring mood.

eess.AS

The PRIORI Emotion Dataset: Linking Mood to Emotion Detected In-the-Wild

Bipolar Disorder is a chronic psychiatric illness characterized by pathological mood swings associated with severe disruptions in emotion regulation. Clinical monitoring of mood is key to the care of these dynamic and incapacitating mood states. Frequent and detailed monitoring improves clinical sensitivity to detect mood state changes, but typically requires costly and limited resources. Speech characteristics change during both depressed and manic states, suggesting automatic methods applied to the speech signal can be effectively used to monitor mood state changes. However, speech is modulated by many factors, which renders mood state prediction challenging. We hypothesize that emotion can be used as an intermediary step to improve mood state prediction. This paper presents critical steps in developing this pipeline, including (1) a new in the wild emotion dataset, the PRIORI Emotion Dataset, collected from everyday smartphone conversational speech recordings, (2) activation/valence emotion recognition baselines on this dataset (PCC of 0.71 and 0.41, respectively), and (3) significant correlation between predicted emotion and mood state for individuals with bipolar disorder. This provides evidence and a working baseline for the use of emotion as a meta-feature for mood state monitoring.

cs.HC

Capturing Long-term Temporal Dependencies with Convolutional Networks for Continuous Emotion Recognition

The goal of continuous emotion recognition is to assign an emotion value to every frame in a sequence of acoustic features. We show that incorporating long-term temporal dependencies is critical for continuous emotion recognition tasks. To this end, we first investigate architectures that use dilated convolutions. We show that even though such architectures outperform previously reported systems, the output signals produced from such architectures undergo erratic changes between consecutive time steps. This is inconsistent with the slow moving ground-truth emotion labels that are obtained from human annotators. To deal with this problem, we model a downsampled version of the input signal and then generate the output signal through upsampling. Not only does the resulting downsampling/upsampling network achieve good performance, it also generates smooth output trajectories. Our method yields the best known audio-only performance on the RECOLA dataset.

cs.SD