Meng Dai | Searcharxiv

arXiv2026

CPTCs Drive Somatic-Visceral Communication via the Wnt Axis in Somatic Mechanotherapy: A Single-Cell Deep Learning Study

Somatic mechanical stimulation (e.g., acupuncture) exerts systemic immunomodulatory effects, yet the cellular bridge translating peripheral physical force into visceral repair remains elusive. Here, employing a custom interpretable deep learning framework (CARSS) on single-cell RNA sequencing data, we identify CD34$^{+}$PDGFR$\alpha$$^{+}$ telocytes (CPTCs) as the primary mechanosensors in both fascia and colon during bacterial colitis. We show that somatic mechanotherapy triggers an AP-1/Hsp70-dependent transcriptional program in fascial CPTCs, inducing systemic Wnt elevation, which elicits a "transcriptional resonance" in colonic CPTCs, reprogramming their communication network from an inflammatory amplifier to a Wnt-driven regenerative hub. Mechanistically, this axis activates epithelial $\beta$-catenin/Myc signaling, suppressing apoptosis and restoring barrier integrity independent of immune cells. Our findings define a CPTC-Driven Mechano-Resonance Axis, where CPTCs serve as synchronized relay stations that convert local mechanical cues into systemic regenerative microenvironments.

q-bio.BM↗

arXiv2025

FLASH-FHE: A Heterogeneous Architecture for Fully Homomorphic Encryption Acceleration

While many hardware accelerators have recently been proposed to address the inefficiency problem of fully homomorphic encryption (FHE) schemes, none of them is able to deliver optimal performance when facing real-world FHE workloads consisting of a mixture of shallow and deep computations, due primarily to their homogeneous design principle. This paper presents FLASH-FHE, the first FHE accelerator with a heterogeneous architecture for mixed workloads. At its heart, FLASH-FHE designs two types of computation clusters, ie, bootstrappable and swift, to optimize for deep and shallow workloads respectively in terms of cryptographic parameters and hardware pipelines. We organize one bootstrappable and two swift clusters into one cluster affiliation, and present a scheduling scheme that provides sufficient acceleration for deep FHE workloads by utilizing all the affiliations, while improving parallelism for shallow FHE workloads by assigning one shallow workload per affiliation and dynamically decomposing the bootstrappable cluster into multiple swift pipelines to accelerate the assigned workload. We further show that these two types of clusters can share valuable on-chip memory, improving performance without significant resource consumption. We implement FLASH-FHE with RTL and synthesize it using both 7nm and 14/12nm technology nodes, and our experiment results demonstrate that FLASH-FHE achieves an average performance improvement of $1.4\times$ and $11.2\times$ compared to state-of-the-art FHE accelerators CraterLake and F1 for deep workloads, while delivering up to $8.0\times$ speedup for shallow workloads due to its heterogeneous architecture.

cs.AR↗