arXiv subjects

Mengliang Zhang

Publications and source records attributed to Mengliang Zhang.

3 recordsLinked to original sources

arXiv2026

Hospital-Specific Bias in Patch-Based Pathology Models

Pathology foundation models (PFMs) achieve strong performance on diverse histopathology tasks, but their sensitivity to hospital-specific domain shifts remains underexplored. We systematically evaluate state-of-the-art PFMs on TCGA patch-level datasets and introduce a lightweight adversarial adaptor to remove hospital-related domain information from latent representations. Experiments show that, while disease classification accuracy is largely maintained, the adaptor effectively reduces hospital-specific bias, as confirmed by t-SNE visualizations. Our study establishes a benchmark for assessing cross-hospital robustness in PFMs and provides a practical strategy for enhancing generalization under heterogeneous clinical settings. Our code is available at https://github.com/MengRes/pfm_domain_bias.

cs.CV↗

arXiv2024

Expert Knowledge-Aware Image Difference Graph Representation Learning for Difference-Aware Medical Visual Question Answering

To contribute to automating the medical vision-language model, we propose a novel Chest-Xray Difference Visual Question Answering (VQA) task. Given a pair of main and reference images, this task attempts to answer several questions on both diseases and, more importantly, the differences between them. This is consistent with the radiologist's diagnosis practice that compares the current image with the reference before concluding the report. We collect a new dataset, namely MIMIC-Diff-VQA, including 700,703 QA pairs from 164,324 pairs of main and reference images. Compared to existing medical VQA datasets, our questions are tailored to the Assessment-Diagnosis-Intervention-Evaluation treatment procedure used by clinical professionals. Meanwhile, we also propose a novel expert knowledge-aware graph representation learning model to address this task. The proposed baseline model leverages expert knowledge such as anatomical structure prior, semantic, and spatial knowledge to construct a multi-relationship graph, representing the image differences between two images for the image difference VQA task. The dataset and code can be found at https://github.com/Holipori/MIMIC-Diff-VQA. We believe this work would further push forward the medical vision language model.

cs.CV↗

arXiv2023

Expert Uncertainty and Severity Aware Chest X-Ray Classification by Multi-Relationship Graph Learning

Patients undergoing chest X-rays (CXR) often endure multiple lung diseases. When evaluating a patient's condition, due to the complex pathologies, subtle texture changes of different lung lesions in images, and patient condition differences, radiologists may make uncertain even when they have experienced long-term clinical training and professional guidance, which makes much noise in extracting disease labels based on CXR reports. In this paper, we re-extract disease labels from CXR reports to make them more realistic by considering disease severity and uncertainty in classification. Our contributions are as follows: 1. We re-extracted the disease labels with severity and uncertainty by a rule-based approach with keywords discussed with clinical experts. 2. To further improve the explainability of chest X-ray diagnosis, we designed a multi-relationship graph learning method with an expert uncertainty-aware loss function. 3. Our multi-relationship graph learning method can also interpret the disease classification results. Our experimental results show that models considering disease severity and uncertainty outperform previous state-of-the-art methods.

cs.CV↗