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Michael Hornquist

Publications and source records attributed to Michael Hornquist.

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Comparison and validation of community structures in complex networks

The issue of partitioning a network into communities has attracted a great deal of attention recently. Most authors seem to equate this issue with the one of finding the maximum value of the modularity, as defined by Newman. Since the problem formulated this way is NP-hard, most effort has gone into the construction of search algorithms, and less to the question of other measures of community structures, similarities between various partitionings and the validation with respect to external information. Here we concentrate on a class of computer generated networks and on three well-studied real networks which constitute a bench-mark for network studies; the karate club, the US college football teams and a gene network of yeast. We utilize some standard ways of clustering data (originally not designed for finding community structures in networks) and show that these classical methods sometimes outperform the newer ones. We discuss various measures of the strength of the modular structure, and show by examples features and drawbacks. Further, we compare different partitions by applying some graph-theoretic concepts of distance, which indicate that one of the quality measures of the degree of modularity corresponds quite well with the distance from the true partition. Finally, we introduce a way to validate the partitionings with respect to external data when the nodes are classified but the network structure is unknown. This is here possible since we know everything of the computer generated networks, as well as the historical answer to how the karate club and the football teams are partitioned in reality. The partitioning of the gene network is validated by use of the Gene Ontology database, where we show that a community in general corresponds to a biological process.

physics.soc-ph

Large-scale reverse engineering by the Lasso

We perform a reverse engineering from the ``extended Spellman data'', consisting of 6178 mRNA levels measured by microarrays at 73 instances in four time series during the cell cycle of the yeast Saccharomyces cerevisae. By assuming a linear model of the genetic regulatory network, and imposing an extra constraint (the Lasso), we obtain a unique inference of coupling parameters. These parameters are transfered into an adjacent matrix, which is analyzed with respect to topological properties and biological relevance. We find a very broad distribution of outdegrees in the network, compatible with earlier findings for biological systems and totally incompatible with a random graph, and also indications of modules in the network. Finally, we show there is an excess of genes coding for transcription factors among the genes of highest outdegrees, a fact which indicates that our approach has biological relevance.

q-bio.MN