arXiv subjects

Michael Hucka

Publications and source records attributed to Michael Hucka.

6 recordsLinked to original sources

arXiv2020

Nine Best Practices for Research Software Registries and Repositories: A Concise Guide

Scientific software registries and repositories serve various roles in their respective disciplines. These resources improve software discoverability and research transparency, provide information for software citations, and foster preservation of computational methods that might otherwise be lost over time, thereby supporting research reproducibility and replicability. However, developing these resources takes effort, and few guidelines are available to help prospective creators of registries and repositories. To address this need, we present a set of nine best practices that can help managers define the scope, practices, and rules that govern individual registries and repositories. These best practices were distilled from the experiences of the creators of existing resources, convened by a Task Force of the FORCE11 Software Citation Implementation Working Group during the years 2019-2020. We believe that putting in place specific policies such as those presented here will help scientific software registries and repositories better serve their users and their disciplines.

cs.DL↗

arXiv2018

Software search is not a science, even among scientists: A survey of how scientists and engineers find software

Improved software discovery is a prerequisite for greater software reuse: after all, if someone cannot find software for a particular task, they cannot reuse it. Understanding people's approaches and preferences when they look for software could help improve facilities for software discovery. We surveyed people working in several scientific and engineering fields to better understand their approaches and selection criteria. We found that even among highly-trained people, the rudimentary approaches of relying on general Web searches, the opinions of colleagues, and the literature were still the most commonly used. However, those who were involved in software development differed from nondevelopers in their use of social help sites, software project repositories, software catalogs, and organization-specific mailing lists or forums. For example, software developers in our sample were more likely to search in community sites such as Stack Overflow even when seeking ready-to-run software rather than source code, and likewise, asking colleagues was significantly more important when looking for ready-to-run software. Our survey also provides insight into the criteria that matter most to people when they are searching for ready-to-run software. Finally, our survey also identifies some factors that can prevent people from finding software.

cs.CY↗

arXiv2018

Creation and analysis of biochemical constraint-based models: the COBRA Toolbox v3.0

COnstraint-Based Reconstruction and Analysis (COBRA) provides a molecular mechanistic framework for integrative analysis of experimental data and quantitative prediction of physicochemically and biochemically feasible phenotypic states. The COBRA Toolbox is a comprehensive software suite of interoperable COBRA methods. It has found widespread applications in biology, biomedicine, and biotechnology because its functions can be flexibly combined to implement tailored COBRA protocols for any biochemical network. Version 3.0 includes new methods for quality controlled reconstruction, modelling, topological analysis, strain and experimental design, network visualisation as well as network integration of chemoinformatic, metabolomic, transcriptomic, proteomic, and thermochemical data. New multi-lingual code integration also enables an expansion in COBRA application scope via high-precision, high-performance, and nonlinear numerical optimisation solvers for multi-scale, multi-cellular and reaction kinetic modelling, respectively. This protocol can be adapted for the generation and analysis of a constraint-based model in a wide variety of molecular systems biology scenarios. This protocol is an update to the COBRA Toolbox 1.0 and 2.0. The COBRA Toolbox 3.0 provides an unparalleled depth of constraint-based reconstruction and analysis methods.

q-bio.QM↗

arXiv2014

One file to share them all: Using the COMBINE Archive and the OMEX format to share all information about a modeling project

Background: With the ever increasing use of computational models in the biosciences, the need to share models and reproduce the results of published studies efficiently and easily is becoming more important. To this end, various standards have been proposed that can be used to describe models, simulations, data or other essential information in a consistent fashion. These constitute various separate components required to reproduce a given published scientific result. Results: We describe the Open Modeling EXchange format (OMEX). Together with the use of other standard formats from the Computational Modeling in Biology Network (COMBINE), OMEX is the basis of the COMBINE Archive, a single file that supports the exchange of all the information necessary for a modeling and simulation experiment in biology. An OMEX file is a ZIP container that includes a manifest file, listing the content of the archive, an optional metadata file adding information about the archive and its content, and the files describing the model. The content of a COMBINE Archive consists of files encoded in COMBINE standards whenever possible, but may include additional files defined by an Internet Media Type. Several tools that support the COMBINE Archive are available, either as independent libraries or embedded in modeling software. Conclusions: The COMBINE Archive facilitates the reproduction of modeling and simulation experiments in biology by embedding all the relevant information in one file. Having all the information stored and exchanged at once also helps in building activity logs and audit trails. We anticipate that the COMBINE Archive will become a significant help for modellers, as the domain moves to larger, more complex experiments such as multi-scale models of organs, digital organisms, and bioengineering.

cs.DL↗

arXiv2013

Large-scale generation of computational models from biochemical pathway maps

Background: Systems biology projects and omics technologies have led to a growing number of biochemical pathway reconstructions. However, mathematical models are still most often created de novo, based on reading the literature and processing pathway data manually. Results: To increase the efficiency with which such models can be created, we automatically generated mathematical models from pathway representations using a suite of freely available software. We produced models that combine data from KEGG PATHWAY, BioCarta, MetaCyc and SABIO-RK; According to the source data, three types of models are provided: kinetic, logical and constraint-based. All models are encoded using SBML Core and Qual packages, and available through BioModels Database. Each model contains the list of participants, the interactions, and the relevant mathematical constructs, but, in most cases, no meaningful parameter values. Most models are also available as easy to understand graphical SBGN maps. Conclusions: to date, the project has resulted in more than 140000 models freely available. We believe this resource can tremendously accelerate the development of mathematical models by providing initial starting points ready for parametrization.

q-bio.MN↗

arXiv2013

SBML Qualitative Models: a model representation format and infrastructure to foster interactions between qualitative modelling formalisms and tools

Background: Qualitative frameworks, especially those based on the logical discrete formalism, are increasingly used to model regulatory and signalling networks. A major advantage of these frameworks is that they do not require precise quantitative data, and that they are well-suited for studies of large networks. While numerous groups have developed specific computational tools that provide original methods to analyse qualitative models, a standard format to exchange qualitative models has been missing. Results: We present the System Biology Markup Language (SBML) Qualitative Models Package ("qual"), an extension of the SBML Level 3 standard designed for computer representation of qualitative models of biological networks. We demonstrate the interoperability of models via SBML qual through the analysis of a specific signalling network by three independent software tools. Furthermore, the cooperative development of the SBML qual format paved the way for the development of LogicalModel, an open-source model library, which will facilitate the adoption of the format as well as the collaborative development of algorithms to analyze qualitative models. Conclusion: SBML qual allows the exchange of qualitative models among a number of complementary software tools. SBML qual has the potential to promote collaborative work on the development of novel computational approaches, as well as on the specification and the analysis of comprehensive qualitative models of regulatory and signalling networks.

q-bio.MN↗