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Michael Kelly

Publications and source records attributed to Michael Kelly.

20 records · Page 2Linked to original sources

Uniform Dilations in Higher Dimensions

A theorem of Glasner says that if $X$ is an infinite subset of the torus $\mathbb{T}$, then for any $ε>0$, there exists an integer $n$ such that the dilation $nX=\{nx: x \in \mathbb{T} \}$ is $ε$-dense (i.e, it intersects any interval of length $2ε$ in $\mathbb{T}$). Alon and Peres provided a general framework for this problem, and showed quantitatively that one can restrict the dilation to be of the form $f(n)X$ where $f \in \mathbb{Z}[x]$ is not constant. Building upon the work of Alon and Peres, we study this phenomenon in higher dimensions. Let ${\bf A}(x)$ be an $L \times N$ matrix whose entries are in $\mathbb{Z}[x]$, and $X$ be an infinite subset of $\mathbb{T}^N$. Contrarily to the case $N=L=1$, it's not always true that there is an integer $n$ such that $\bA(n)X$ is $ε$-dense in a translate of a subtorus of $\mathbb{T}^{L}$. We give a necessary and sufficient condition for matrices ${\bf A}$ for which this is true. We also prove an effective version of the result.

math.NT↗

A Hierarchical Probability Model of Colon Cancer

We consider a model of fixed size $N = 2^l$ in which there are $l$ generations of daughter cells and a stem cell. In each generation $i$ there are $2^{i-1}$ daughter cells. At each integral time unit the cells split so that the stem cell splits into a stem cell and generation 1 daughter cell and the generation $i$ daughter cells become two cells of generation $i+1$. The last generation is removed from the population. The stem cell gets first and second mutations at rates $u_1$ and $u_2$ and the daughter cells get first and second mutations at rates $v_1$ and $v_2$. We find the distribution for the time it takes to get two mutations as $N$ goes to infinity and the mutation rates go to 0. We also find the distribution for the location of the mutations. Several outcomes are possible depending on how fast the rates go to 0. The model considered has been proposed by Komarova (2007) as a model for colon cancer.

math.PR↗