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Michail Tsagris

Publications and source records attributed to Michail Tsagris.

36 records · Page 2Linked to original sources

The FEDHC Bayesian network learning algorithm

The paper proposes a new hybrid Bayesian network learning algorithm, termed Forward Early Dropping Hill Climbing (FEDHC), devised to work with either continuous or categorical variables. Further, the paper manifests that the only implementation of MMHC in the statistical software \textit{R}, is prohibitively expensive and a new implementation is offered. Further, specifically for the case of continuous data, a robust to outliers version of FEDHC, that can be adopted by other BN learning algorithms, is proposed. The FEDHC is tested via Monte Carlo simulations that distinctly show it is computationally efficient, and produces Bayesian networks of similar to, or of higher accuracy than MMHC and PCHC. Finally, an application of FEDHC, PCHC and MMHC algorithms to real data, from the field of economics, is demonstrated using the statistical software \textit{R}.

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Estimating NBA players salary share according to their performance on court: A machine learning approach

It is customary for researchers and practitioners to fit linear models in order to predict NBA player's salary based on the players' performance on court. On the contrary, we focus on the players salary share (with regards to the team payroll) by first selecting the most important determinants or statistics (years of experience in the league, games played, etc.) and then utilise them to predict the player salaries by employing a non linear Random Forest machine learning algorithm. We externally evaluate our salary predictions, thus we avoid the phenomenon of over-fitting observed in most papers. Overall, using data from three distinct periods, 2017-2019 we identify the important factors that achieve very satisfactory salary predictions and we draw useful conclusions.

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A generalised OMP algorithm for feature selection with application to gene expression data

Feature selection for predictive analytics is the problem of identifying a minimal-size subset of features that is maximally predictive of an outcome of interest. To apply to molecular data, feature selection algorithms need to be scalable to tens of thousands of available features. In this paper, we propose gOMP, a highly-scalable generalisation of the Orthogonal Matching Pursuit feature selection algorithm to several directions: (a) different types of outcomes, such as continuous, binary, nominal, and time-to-event, (b) different types of predictive models (e.g., linear least squares, logistic regression), (c) different types of predictive features (continuous, categorical), and (d) different, statistical-based stopping criteria. We compare the proposed algorithm against LASSO, a prototypical, widely used algorithm for high-dimensional data. On dozens of simulated datasets, as well as, real gene expression datasets, gOMP is on par, or outperforms LASSO for case-control binary classification, quantified outcomes (regression), and (censored) survival times (time-to-event) analysis. gOMP has also several theoretical advantages that are discussed. While gOMP is based on quite simple and basic statistical ideas, easy to implement and to generalize, we also show in an extensive evaluation that it is also quite effective in bioinformatics analysis settings.

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Hypothesis testing for two population means: parametric or non-parametric test?

The parametric Welch $t$-test and the non-parametric Wilcoxon-Mann-Whitney test are the most commonly used two independent sample means tests. More recent testing approaches include the non-parametric, empirical likelihood and exponential empirical likelihood. However, the applicability of these non-parametric likelihood testing procedures is limited partially because of their tendency to inflate the type I error in small sized samples. In order to circumvent the type I error problem, we propose simple calibrations using the $t$ distribution and bootstrapping. The two non-parametric likelihood testing procedures, with and without those calibrations, are then compared against the Wilcoxon-Mann-Whitney test and the Welch $t$-test. The comparisons are implemented via extensive Monte Carlo simulations on the grounds of type I error and power in small/medium sized samples generated from various non-normal populations. The simulation studies clearly demonstrate that a) the $t$ calibration improves the type I error of the empirical likelihood, b) bootstrap calibration improves the type I error of both non-parametric likelihoods, c) the Welch $t$-test with or without bootstrap calibration attains the type I error and produces similar levels of power with the former testing procedures, and d) the Wilcoxon-Mann-Whitney test produces inflated type I error while the computation of an exact p-value is not feasible in the presence of ties with discrete data. Further, an application to real gene expression data illustrates the computational high cost and thus the impracticality of the non parametric likelihoods. Overall, the Welch t-test, which is highly computationally efficient and readily interpretable, is shown to be the best method when testing equality of two population means.

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A folded model for compositional data analysis

A folded type model is developed for analyzing compositional data. The proposed model involves an extension of the $α$-transformation for compositional data and provides a new and flexible class of distributions for modeling data defined on the simplex sample space. Despite its rather seemingly complex structure, employment of the EM algorithm guarantees efficient parameter estimation. The model is validated through simulation studies and examples which illustrate that the proposed model performs better in terms of capturing the data structure, when compared to the popular logistic normal distribution, and can be advantageous over a similar model without folding.

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Gaussian asymptotic limits for the $α$-transformation in the analysis of compositional data

Compositional data consists of vectors of proportions whose components sum to 1. Such vectors lie in the standard simplex, which is a manifold with boundary. One issue that has been rather controversial within the field of compositional data analysis is the choice of metric on the simplex. One popular possibility has been to use the metric implied by logtransforming the data, as proposed by Aitchison [1, 2]; and another popular approach has been to use the standard Euclidean metric inherited from the ambient space. Tsagris et al. [21] proposed a one-parameter family of power transformations, the $α$-transformations, which include both the metric implied by Aitchison's transformation and the Euclidean metric as particular cases. Our underlying philosophy is that, with many datasets, it may make sense to use the data to help us determine a suitable metric. A related possibility is to apply the $α$-transformations to a parametric family of distributions, and then estimate a along with the other parameters. However, as we shall see, when one follows this last approach with the Dirichlet family, some care is needed in a certain limiting case which arises $(α\neq 0)$, as we found out when fitting this model to real and simulated data. Specifically, when the maximum likelihood estimator of a is close to 0, the other parameters tend to be large. The main purpose of the paper is to study this limiting case both theoretically and numerically and to provide insight into these numerical findings.

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Extremely efficient permutation and bootstrap hypothesis tests using R

Re-sampling based statistical tests are known to be computationally heavy, but reliable when small sample sizes are available. Despite their nice theoretical properties not much effort has been put to make them efficient. In this paper we treat the case of Pearson correlation coefficient and two independent samples t-test. We propose a highly computationally efficient method for calculating permutation based p-values in these two cases. The method is general and can be applied or be adopted to other similar two sample mean or two mean vectors cases.

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A Dirichlet Regression Model for Compositional Data with Zeros

Compositional data are met in many different fields, such as economics, archaeometry, ecology, geology and political sciences. Regression where the dependent variable is a composition is usually carried out via a log-ratio transformation of the composition or via the Dirichlet distribution. However, when there are zero values in the data these two ways are not readily applicable. Suggestions for this problem exist, but most of them rely on substituting the zero values. In this paper we adjust the Dirichlet distribution when covariates are present, in order to allow for zero values to be present in the data, without modifying any values. To do so, we modify the log-likelihood of the Dirichlet distribution to account for zero values. Examples and simulation studies exhibit the performance of the zero adjusted Dirichlet regression.

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Conditional independence test for categorical data using Poisson log-linear model

We demonstrate how to test for conditional independence of two variables with categorical data using Poisson log-linear models. The size of the conditioning set of variables can vary from 0 (simple independence) up to many variables. We also provide a function in R for performing the test. Instead of calculating all possible tables with for loop we perform the test using the log-linear models and thus speeding up the process. Time comparison simulation studies are presented.

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Feature Selection with the R Package MXM: Discovering Statistically-Equivalent Feature Subsets

The statistically equivalent signature (SES) algorithm is a method for feature selection inspired by the principles of constrained-based learning of Bayesian Networks. Most of the currently available feature-selection methods return only a single subset of features, supposedly the one with the highest predictive power. We argue that in several domains multiple subsets can achieve close to maximal predictive accuracy, and that arbitrarily providing only one has several drawbacks. The SES method attempts to identify multiple, predictive feature subsets whose performances are statistically equivalent. Under that respect SES subsumes and extends previous feature selection algorithms, like the max-min parent children algorithm. SES is implemented in an homonym function included in the R package MXM, standing for mens ex machina, meaning 'mind from the machine' in Latin. The MXM implementation of SES handles several data-analysis tasks, namely classification, regression and survival analysis. In this paper we present the SES algorithm, its implementation, and provide examples of use of the SES function in R. Furthermore, we analyze three publicly available data sets to illustrate the equivalence of the signatures retrieved by SES and to contrast SES against the state-of-the-art feature selection method LASSO. Our results provide initial evidence that the two methods perform comparably well in terms of predictive accuracy and that multiple, equally predictive signatures are actually present in real world data.

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Nonparametric hypothesis testing for equality of means on the simplex

In the context of data that lie on the simplex, we investigate use of empirical and exponential empirical likelihood, and Hotelling and James statistics, to test the null hypothesis of equal population means based on two independent samples. We perform an extensive numerical study using data simulated from various distributions on the simplex. The results, taken together with practical considerations regarding implementation, support the use of bootstrap-calibrated James statistic.

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A novel, divergence based, regression for compositional data

In compositional data, an observation is a vector with non-negative components which sum to a constant, typically 1. Data of this type arise in many areas, such as geology, archaeology, biology, economics and political science amongst others. The goal of this paper is to propose a new, divergence based, regression modelling technique for compositional data. To do so, a recently proved metric which is a special case of the Jensen-Shannon divergence is employed. A strong advantage of this new regression technique is that zeros are naturally handled. An example with real data and simulation studies are presented and are both compared with the log-ratio based regression suggested by Aitchison in 1986.

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Exploring the Distribution for the Estimator of Rosenthal's 'Fail-Safe' Number of Unpublished Studies in Meta-analysis

The present paper discusses the statistical distribution for the estimator of Rosenthal's 'Fail-Safe' number NR, which is an estimator of unpublished studies in meta-analysis. We calculate the probability distribution function of NR. This is achieved based on the Central Limit Theorem and the proposition that certain components of the estimator NR follow a half normal distribution, derived from the standard normal distribution. Our proposed distributions are supported by simulations and investigation of convergence.

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Publication Bias in Meta-Analysis: Confidence Intervals for Rosenthal's Fail-Safe Number

The purpose of the present paper is to assess the efficacy of confidence intervals for Rosenthal's fail-safe number. Although Rosenthal's estimator is highly used by researchers, its statistical properties are largely unexplored. First of all, we developed statistical theory which allowed us to produce confidence intervals for Rosenthal's fail-safe number.This was produced by discerning whether the number of studies analysed in a meta-analysis is fixed or random. Each case produces different variance estimators. For a given number of studies and a given distribution, we provided five variance estimators. Confidence intervals are examined with a normal approximation and a nonparametric bootstrap. The accuracy of the different confidence interval estimates was then tested by methods of simulation under different distributional assumptions. The half normal distribution variance estimator has the best probability coverage. Finally, we provide a table of lower confidence intervals for Rosenthal's estimator.

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Improved classification for compositional data using the $α$-transformation

In compositional data analysis an observation is a vector containing non-negative values, only the relative sizes of which are considered to be of interest. Without loss of generality, a compositional vector can be taken to be a vector of proportions that sum to one. Data of this type arise in many areas including geology, archaeology, biology, economics and political science. In this paper we investigate methods for classification of compositional data. Our approach centres on the idea of using the $α$-transformation to transform the data and then to classify the transformed data via regularised discriminant analysis and the k-nearest neighbours algorithm. Using the $α$-transformation generalises two rival approaches in compositional data analysis, one (when $α=1$) that treats the data as though they were Euclidean, ignoring the compositional constraint, and another (when $α=0$) that employs Aitchison's centred log-ratio transformation. A numerical study with several real datasets shows that whether using $α=1$ or $α=0$ gives better classification performance depends on the dataset, and moreover that using an intermediate value of $α$ can sometimes give better performance than using either 1 or 0.

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The k-NN algorithm for compositional data: a revised approach with and without zero values present

In compositional data, an observation is a vector with non-negative components which sum to a constant, typically 1. Data of this type arise in many areas, such as geology, archaeology, biology, economics and political science among others. The goal of this paper is to extend the taxicab metric and a newly suggested metric for compositional data by employing a power transformation. Both metrics are to be used in the k-nearest neighbours algorithm regardless of the presence of zeros. Examples with real data are exhibited.

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On the folded normal distribution

The characteristic function of the folded normal distribution and its moment function are derived. The entropy of the folded normal distribution and the Kullback--Leibler from the normal and half normal distributions are approximated using Taylor series. The accuracy of the results are also assessed using different criteria. The maximum likelihood estimates and confidence intervals for the parameters are obtained using the asymptotic theory and bootstrap method. The coverage of the confidence intervals is also examined.

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