arXiv subjects

Michele Caselle

Publications and source records attributed to Michele Caselle.

At least 73 records · Page 4Linked to original sources

arXiv2016

Jarzynski's theorem for lattice gauge theory

Jarzynski's theorem is a well-known equality in statistical mechanics, which relates fluctuations in the work performed during a non-equilibrium transformation of a system, to the free-energy difference between two equilibrium ensembles. In this article, we apply Jarzynski's theorem in lattice gauge theory, for two examples of challenging computational problems, namely the calculation of interface free energies and the determination of the equation of state. We conclude with a discussion of further applications of interest in QCD and in other strongly coupled gauge theories, in particular for the Schroedinger functional and for simulations at finite density using reweighting techniques.

hep-lat↗

arXiv2016

Conformal perturbation of off-critical correlators in the 3D Ising universality class

Thanks to the impressive progress of conformal bootstrap methods we have now very precise estimates of both scaling dimensions and OPE coefficients for several 3D universality classes. We show how to use this information to obtain similarly precise estimates for off-critical correlators using conformal perturbation. We discuss in particular the $< σ(r) σ(0) >$, $< ε(r) ε(0) >$ and $< σ(r) ε(0) >$ two point functions in the high and low temperature regimes of the 3D Ising model and evaluate the leading and next to leading terms in the $s = t r^{Δ_{t}}$ expansion, where $t$ is the reduced temperature. Our results for $< σ(r) σ(0) >$ agree both with Monte Carlo simulations and with a set of experimental estimates of the critical scattering function.

hep-th↗

arXiv2016

Fast Mapping of Terahertz Bursting Thresholds and Characteristics at Synchrotron Light Sources

Dedicated optics with extremely short electron bunches enable synchrotron light sources to generate intense coherent THz radiation. The high degree of spatial compression in this so-called low-alpha optics entails a complex longitudinal dynamics of the electron bunches, which can be probed studying the fluctuations in the emitted terahertz radiation caused by the micro-bunching instability ("bursting"). This article presents a "quasi-instantaneous" method for measuring the bursting characteristics by simultaneously collecting and evaluating the information from all bunches in a multi-bunch fill, reducing the measurement time from hours to seconds. This speed-up allows systematic studies of the bursting characteristics for various accelerator settings within a single fill of the machine, enabling a comprehensive comparison of the measured bursting thresholds with theoretical predictions by the bunched-beam theory. This paper introduces the method and presents first results obtained at the ANKA synchrotron radiation facility.

physics.acc-ph↗

arXiv2016

Width of the flux tube in compact U(1) gauge theory in three dimensions

We study the squared width and the profile of flux tubes in compact U(1) lattice gauge theory in three spacetime dimensions. The results obtained from numerical calculations in the dual formulation of this confining theory are compared with predictions from an effective bosonic-string model and from the dual-superconductor model: it is found that the former fails at describing the quantitative features of the flux tube, while the latter is in good agreement with Monte Carlo data. The analytical interpretation of these results (in the light of the semi-classical analysis by Polyakov) is pointed out, and a comparison with non-Abelian gauge theories in four spacetime dimensions is discussed.

hep-lat↗

arXiv2015

Detection of gene communities in multi-networks reveals cancer drivers

We propose a new multi-network-based strategy to integrate different layers of genomic information and use them in a coordinate way to identify driving cancer genes. The multi-networks that we consider combine transcription factor co-targeting, microRNA co-targeting, protein-protein interaction and gene co-expression networks. The rationale behind this choice is that gene co-expression and protein-protein interactions require a tight coregulation of the partners and that such a fine tuned regulation can be obtained only combining both the transcriptional and post-transcriptional layers of regulation. To extract the relevant biological information from the multi-network we studied its partition into communities. To this end we applied a consensus clustering algorithm based on state of art community detection methods. Even if our procedure is valid in principle for any pathology in this work we concentrate on gastric, lung, pancreas and colorectal cancer and identified from the enrichment analysis of the multi-network communities a set of candidate driver cancer genes. Some of them were already known oncogenes while a few are new. The combination of the different layers of information allowed us to extract from the multi-network indications on the regulatory pattern and functional role of both the already known and the new candidate driver genes.

q-bio.MN↗

arXiv2015

Hagedorn spectrum and equation of state of Yang-Mills theories

We present a novel lattice calculation of the equation of state of SU(2) Yang-Mills theory in the confining phase. We show that a gas of massive, non-interacting glueballs describes remarkably well the results, provided that a bosonic closed-string model is used to derive an exponentially growing Hagedorn spectrum for the heavy glueball states with no free parameters. This effective model can be applied to SU(3) Yang-Mills theory and the theoretical prediction agrees nicely with the lattice results reported by Borsányi et al. in JHEP 07 (2012) 056.

hep-lat↗

arXiv2015

Exceptional thermodynamics: The equation of state of G(2) gauge theory

We present a lattice study of the equation of state in Yang-Mills theory based on the exceptional G(2) gauge group. As is well-known, at zero temperature this theory shares many qualitative features with real-world QCD, including the absence of colored states in the spectrum and dynamical string breaking at large distances. In agreement with previous works, we show that at finite temperature this theory features a first-order deconfining phase transition, whose nature can be studied by a semi-classical computation. We also show that the equilibrium thermodynamic observables in the deconfined phase bear striking quantitative similarities with those found in SU(N) gauge theories: in particular, these quantities exhibit nearly perfect proportionality to the number of gluon degrees of freedom, and the trace anomaly reveals a characteristic quadratic dependence on the temperature, also observed in SU(N) Yang-Mills theories (both in four and in three spacetime dimensions). We compare our lattice data with analytical predictions from effective models, and discuss their implications for the deconfinement mechanism and high-temperature properties of strongly interacting, non-supersymmetric gauge theories. Our results give strong evidence for the conjecture that the thermal deconfining transition is governed by a universal mechanism, common to all simple gauge groups.

hep-lat↗

arXiv2015

A different kind of string

In U(1) lattice gauge theory in three spacetime dimensions, the problem of confinement can be studied analytically in a semi-classical approach, in terms of a gas of monopoles with Coulomb-like interactions. In addition, this theory can be mapped to a spin model via an exact duality transformation, which allows one to perform high-precision numerical studies of the confining potential. Taking advantage of these properties, we carried out an accurate investigation of the effective string describing the low-energy properties of flux tubes in this confining gauge theory. We found striking deviations from the expected Nambu-Goto-like behavior, and, for the first time, evidence for contributions that can be described by a term proportional to the extrinsic curvature of the effective string worldsheet. Such term is allowed by Lorentz invariance, and its presence in the infrared regime of the U(1) model was indeed predicted by Polyakov several years ago. Our results show that this term scales as expected according to Polyakov's solution, and becomes the dominant contribution to the effective string action in the continuum limit. We also demonstrate analytically that the corrections to the confining potential induced by the extrinsic curvature term can be related to the partition function of the massive perturbation of a c=1 bosonic conformal field theory. The implications of our results for SU(N) Yang-Mills theories in three and in four spacetime dimensions are discussed.

hep-lat↗

arXiv2014

On the rigid string contribution to the interquark potential

Owing to Lorentz invariance, the leading terms in the effective action describing the low-energy dynamics of flux tubes in a confining gauge theory are universal. Besides the terms corresponding to the Nambu-Goto action, Lorentz invariance also allows terms describing a "rigid string", proposed long ago by Kleinert and Polyakov as a model for confinement in a dual superconductor scenario. In this contribution we discuss some of the non-trivial properties of this type of string and evaluate analytically the corrections to the interquark potential induced by extrinsic curvature terms appearing in the rigid string action.

hep-lat↗

arXiv2014

Effective string description of the interquark potential in the 3D U(1) lattice gauge theory

The U(1) lattice gauge theory in three dimensions is a perfect laboratory to study the properties of the confining string. On the one hand, thanks to the mapping to a Coulomb gas of monopoles, the confining properties of the model can be studied semi-classically. On the other hand, high-precision numerical estimates of Polyakov loop correlators can be obtained via a duality map to a spin model. This allowed us to perform high-precision tests of the universal behavior of the effective string and to find macroscopic deviations with respect to the expected Nambu-Goto predictions. These corrections could be fitted with very good precision including a contribution (which is consistent with Lorentz symmetry) proportional to the square of the extrinsic curvature in the effective string action, as originally suggested by Polyakov. Performing our analysis at different values of $β$ we were able to show that this term scales as expected by Polyakov's solution and dominates in the continuum. We also discuss the interplay between the extrinsic curvature contribution and the boundary correction induced by the Polyakov loops.

hep-lat↗

arXiv2014

Recent progress in the effective string theory description of LGTs

In presence of a static pair of sources, the spectrum of low-lying states of any confining gauge theory in D space-time dimensions is described, at large source separations, by an effective string theory. Recently two important advances improved our understanding of this effective theory. First, it was realized that the form of the effective action is strongly constrained by the requirement of the Lorentz invariance of the gauge theory, which is spontaneously broken by the formation of a long confining flux tube in the vacuum. This constraint is strong enough to fix uniquely the first few subleading terms of the action. Second, it has been realized that the first of these allowed terms - a quartic polynomial in the field derivatives - is exactly the composite field $T\bar{T}$, built with the chiral components, $T$ and $\bar{T}$, of the energy-momentum tensor of the 2d QFT describing the infrared limit of the effective string. This irrelevant perturbation is quantum integrable and yields, through the thermodynamic Bethe Ansatz (TBA), the energy levels of the string which exactly coincide with the Nambu-Goto spectrum. In this talk we first review the general implications of these two results and then, as a test of the power of these methods, use them to construct the first few boundary corrections to the effective string action.

hep-lat↗

arXiv2013

Fine structure of the confining string in an analytically solvable 3D model

In $\mathrm{U(1)}$ lattice gauge theory in three spacetime dimensions, confinement can be analytically shown to persist at all values of the coupling. Furthermore, the explicit predictions for the dependence of string tension $σ$ and mass gap $m_0$ on the coupling allow one to tune their ratio at will. These features, and the possibility of obtaining high-precision numerical results via an exact duality map to a spin model, make this theory an ideal laboratory to test the effective string description of confining flux tubes. In this contribution, we discuss our investigation of next-to-leading-order corrections to the confining potential and of the finite-temperature behavior of the flux tube width. Our data provide a very stringent test of the theoretical predictions for these quantities and allow to test their dependence on the $m_0/\sqrtσ$ ratio.

hep-lat↗

arXiv2013

A combination of transcriptional and microRNA regulation improves the stability of the relative concentrations of target genes

It is well known that, under suitable conditions, microRNAs are able to fine tune the relative concentration of their targets to any desired value. We show that this function is particularly effective when one of the targets is a Transcription Factor (TF) which regulates the other targets. This combination defines a new class of feed-forward loops (FFLs) in which the microRNA plays the role of master regulator. Using both deterministic and stochastic equations we show that these FFLs are indeed able not only to fine-tune the TF/target ratio to any desired value as a function of the miRNA concentration but also, thanks to the peculiar topology of the circuit, to ensures the stability of this ratio against stochastic fluctuations. These two effects are due to the interplay between the direct transcriptional regulation and the indirect TF/Target interaction due to competition of TF and target for miRNA binding (the so called "sponge effect"). We then perform a genome wide search of these FFLs in the human regulatory network and show that they are characterizedby a very peculiar enrichment pattern. In particular they are strongly enriched in all the situations in which the TF and its target have to be precisely kept at the same concentration notwithstanding the environmental noise. As an example we discuss the FFL involving E2F1 as Transcription Factor, RB1 as target and miR-17 family as master regulator. These FFLs ensure a tight control of the E2F/RB ratio which in turns ensures the stability of the transition from the G0/G1 to the S phase in quiescent cells.

q-bio.MN↗

arXiv2013

Quantisation of the effective string with TBA

In presence of a static pair of sources, the spectrum of low-lying states of whatever confining gauge theory in D space-time dimensions is described, at large source separations, by an effective string theory. In the far infrared the latter flows, in the static gauge, to a two-dimensional massless free-field theory. It is known that the Lorentz invariance of the gauge theory fixes uniquely the first few subleading corrections of this free-field limit. We point out that the first allowed correction - a quartic polynomial in the field derivatives - is exactly the composite field $T\bar{T}$, built with the chiral components, $T$ and $\bar{T}$, of the energy-momentum tensor. This irrelevant perturbation is quantum integrable and yields, through the thermodynamic Bethe Ansatz (TBA),the energy levels of the string which exactly coincide with the Nambu-Goto spectrum. We obtain this way the results recently found by Dubovsky, Flauger and Gorbenko. This procedure easily generalizes to any two-dimensional CFT. It is known that the leading deviation of the Nambu-Goto spectrum comes from the boundary terms of the string action. We solve the TBA equations on an infinite strip, identify the relevant boundary parameter and verify that it modifies the string spectrum as expected.

hep-th↗

arXiv2013

Finite temperature behaviour of glueballs in Lattice Gauge Theories

We propose a new method to compute glueball masses in finite temperature Lattice Gauge Theories which at low temperature is fully compatible with the known zero temperature results and as the temperature increases leads to a glueball spectrum which vanishes at the deconfinement transition. We show that this definition is consistent with the Isgur-Paton model and with the expected contribution of the glueball spectrum to various thermodynamic quantities at finite temperature. We test our proposal with a set of high precision numerical simulations in the 3d gauge Ising model and find a good agreement with our predictions.

hep-lat↗

arXiv2013

New numerical results and novel effective string predictions for Wilson loops

We compute the prediction of the Nambu-Goto effective string model for a rectangular Wilson loop up to three loops. This is done through the use of an operatorial, first order formulation and of the open string analogues of boundary states. This result is interesting since there are universality theorems stating that the predictions up to three loops are common to all effective string models. To test the effective string prediction, we set up the Montecarlo evaluation, in the 3d Ising gauge model, of an observable (the ratio of two Wilson loops with the same perimeter) for which boundary effects are relatively small. Our simulation attains a level of precision which is sufficient to test the two-loop correction. The three-loop correction seems to go in the right direction, but is actually yet beyond the reach of our simulation, since its effect is comparable with the statistical errors of the latter.

hep-th↗

arXiv2012

On the intrinsic width of the chromoelectric flux tube in finite temperature LGTs

We propose three different lattice operators to measure the intrinsic width ξ_I of the chromoelectric flux tube in pure lattice gauge theories. In order to test these proposals we evaluate them for SU(2) and Ising LGTs in (2+1) dimensions in the vicinity of the deconfinement transition. Using dimensional reduction, we could perform the calculation in the effective 2d spin model using standard S-matrix techniques. We consistently found the same result for the three lattice operators. This result can be expressed in terms of the finite temperature string tension as follows ξ_I=\frac{T}{2σ(T)} and implies that the intrinsic width of the flux tube diverges as the deconfinement transition is approached.

hep-th↗

arXiv2012

Gene autoregulation via intronic microRNAs and its functions

Background: MicroRNAs, post-transcriptional repressors of gene expression, play a pivotal role in gene regulatory networks. They are involved in core cellular processes and their dysregulation is associated to a broad range of human diseases. This paper focus on a minimal microRNA-mediated regulatory circuit, in which a protein-coding gene (host gene) is targeted by a microRNA located inside one of its introns. Results: Autoregulation via intronic microRNAs is widespread in the human regulatory network, as confirmed by our bioinformatic analysis, and can perform several regulatory tasks despite its simple topology. Our analysis, based on analytical calculations and simulations, indicates that this circuitry alters the dynamics of the host gene expression, can induce complex responses implementing adaptation and Weber's law, and efficiently filters fluctuations propagating from the upstream network to the host gene. A fine-tuning of the circuit parameters can optimize each of these functions. Interestingly, they are all related to gene expression homeostasis, in agreement with the increasing evidence suggesting a role of microRNA regulation in conferring robustness to biological processes. In addition to model analysis, we present a list of bioinformatically predicted candidate circuits in human for future experimental tests. Conclusions: The results presented here suggest a potentially relevant functional role for negative self-regulation via intronic microRNAs, in particular as a homeostatic control mechanism of gene expression. Moreover, the map of circuit functions in terms of experimentally measurable parameters, resulting from our analysis, can be a useful guideline for possible applications in synthetic biology.

q-bio.MN↗