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Michele Miranda

Publications and source records attributed to Michele Miranda.

5 recordsLinked to original sources

Multilingual Artificial Datasets for AI-Driven Cardiology: the CliTe and ParaCliTe corpora

Background and Aims. Comparable, multilingual, validated cardiology corpora are critical to advance trustworthy natural language processing (NLP) models for cardiology but such resources are scarce due to privacy concerns. This study aimed to cover this gap by presenting suitable artificial corpus creation guidelines and by releasing 3 multilanguage corpora. Methods. Following purpose-specific publicly-available corpus construction guidelines, cardiologists from 7 European hospitals generated artificial clinical records in Czech, Dutch, English, Italian, Romanian, Spanish and Swedish, ensuring clinical diversity and sex balance, resulting in the CliTe corpus. A CliTe subset underwent a multi-stage manual translation into the other 6 languages, resulting in the parallel ParaCliTe corpus, while the remaining reports were automatically translated, constituting ParaCliTe Silver. Results. CliTe is a collection of 699 artificial cardiology reports, mostly outpatient notes (340 documents), discharge reports (263), and inpatient notes (89), describing fictional patients with ischaemic heart disease (199 patients), heart failure (188), and valvular disease (79), among others. ParaCliTe contains reports from 94 fictitious patients, each available in seven languages with sentence-level alignment, resulting in 658 documents. The corpus mainly comprises discharge reports (322 documents), and outpatient (196) and inpatient (140) notes, describing patients with heart failure (399 documents), ischaemic heart disease (287), and valvular disease (238). Empirical results illustrate the utility of ParaCliTe and highlight the limitations of state-of-the-art NLP models adapted to the cardiology domain. Conclusions. The creation of multilingual, equitable and realistic corpora of artificial patients capable of strengthening NLP performance for cardiology is feasible when supported by detailed guidelines.

cs.CL↗

CardioLM: A multilingual suite of small language models for the cardiology domain

Background: Cardiovascular care generates large volumes of clinical free-text documentation in local languages. However, clinical natural language processing (NLP) resources remain concentrated in English, and no existing benchmark is cardiology-specific, multilingual, and broad in entity coverage. Methods: We present two contributions. The first is CardioCCC, a corpus of 508 cardiology case reports originally published in Spanish and extended to Czech, Dutch, English, Italian, Romanian, and Swedish through machine translation, annotation projection, and clinician review, with annotations covering diseases, symptoms, procedures, and medications. The second is CardioLM, comprising CardioBERTa, a set of language-specific encoders obtained by continued pretraining on cardiology and biomedical corpora, and CardioNER, a set of named entity recognition (NER) models fine-tuned on CardioCCC. Results: Cardiology-specific pretraining reduced pseudo-perplexity by up to a factor of eight, yet changed strict span-level F1 by at most 0.04, with benefits concentrated in languages whose backbones lacked biomedical coverage. The jointly trained multilingual XLM-RoBERTa-large models achieved the best strict F1 in nearly every language and entity type, exceeding the strongest monolingual system by up to 0.13 F1. A large share of residual errors concerned boundary detection: relaxed matching recovered 0.10-0.23 F1 for disease, procedure, and symptom, but only 0.01-0.07 for medication. Clinicians rated CardioNER well above a rule- and dictionary-based baseline, with the mean rating across entity types rising from 26% to 73%. Conclusions: Specialty-specific pretraining is not the decisive factor for downstream entity recognition, whereas multilingual joint training yields the strongest results in nearly all settings and a simpler deployment path for multi-country clinical information extraction.

cs.CL↗

Differentially Private De-identification of Dutch Clinical Notes: A Comparative Evaluation

Protecting patient privacy in clinical narratives is essential for enabling secondary use of healthcare data under regulations such as GDPR and HIPAA. While manual de-identification remains the gold standard, it is costly and slow, motivating the need for automated methods that combine privacy guarantees with high utility. Most automated text de-identification pipelines employed named entity recognition (NER) to identify protected entities for redaction. Although methods based on differential privacy (DP) provide formal privacy guarantees, more recently also large language models (LLMs) are increasingly used for text de-identification in the clinical domain. In this work, we present the first comparative study of DP, NER, and LLMs for Dutch clinical text de-identification. We investigate these methods separately as well as hybrid strategies that apply NER or LLM preprocessing prior to DP, and assess performance in terms of privacy leakage and extrinsic evaluation (entity and relation classification). We show that DP mechanisms alone degrade utility substantially, but combining them with linguistic preprocessing, especially LLM-based redaction, significantly improves the privacy-utility trade-off.

cs.CR↗

Preserving Privacy in Large Language Models: A Survey on Current Threats and Solutions

Large Language Models (LLMs) represent a significant advancement in artificial intelligence, finding applications across various domains. However, their reliance on massive internet-sourced datasets for training brings notable privacy issues, which are exacerbated in critical domains (e.g., healthcare). Moreover, certain application-specific scenarios may require fine-tuning these models on private data. This survey critically examines the privacy threats associated with LLMs, emphasizing the potential for these models to memorize and inadvertently reveal sensitive information. We explore current threats by reviewing privacy attacks on LLMs and propose comprehensive solutions for integrating privacy mechanisms throughout the entire learning pipeline. These solutions range from anonymizing training datasets to implementing differential privacy during training or inference and machine unlearning after training. Our comprehensive review of existing literature highlights ongoing challenges, available tools, and future directions for preserving privacy in LLMs. This work aims to guide the development of more secure and trustworthy AI systems by providing a thorough understanding of privacy preservation methods and their effectiveness in mitigating risks.

cs.CR↗

On integration by parts formula on open convex sets in Wiener spaces

In Euclidean space, it is well known that any integration by parts formula for a set of finite perimeter $Ω$ is expressed by the integration with respect to a measure $P(Ω,\cdot)$ which is equivalent to the one-codimensional Hausdorff measure restricted to the reduced boundary of $Ω$. The same result has been proved in an abstract Wiener space, typically an infinite dimensional space, where the surface measure considered is the one-codimensional spherical Hausdorff-Gauss measure $\mathscr S^{\infty-1}$ restricted to the measure-theoretic boundary of $Ω$. In this paper we consider an open convex set $Ω$ and we provide an explicit formula for the density of $P(Ω,\cdot)$ with respect to $\mathscr S^{\infty-1}$. In particular, the density can be written in terms of the Minkowski functional $\p$ of $Ω$ with respect to an inner point of $Ω$. As a consequence, we obtain an integration by parts formula for open convex sets in Wiener spaces.

math.FA↗