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Michelle Zhang

Publications and source records attributed to Michelle Zhang.

2 recordsLinked to original sources

Opening Articulated Structures in the Real World

What does it take to build mobile manipulation systems that can competently operate on previously unseen objects in previously unseen environments? This work answers this question using opening of articulated structures as a mobile manipulation testbed. Specifically, our focus is on the end-to-end performance on this task without any privileged information, i.e. the robot starts at a location with the novel target articulated object in view, and has to approach the object and successfully open it. We first develop a system for this task, and then conduct 100+ end-to-end system tests across 13 real world test sites. Our large-scale study reveals a number of surprising findings: a) modular systems outperform end-to-end learned systems for this task, even when the end-to-end learned systems are trained on 1000+ demonstrations, b) perception, and not precise end-effector control, is the primary bottleneck to task success, and c) state-of-the-art articulation parameter estimation models developed in isolation struggle when faced with robot-centric viewpoints. Overall, our findings highlight the limitations of developing components of the pipeline in isolation and underscore the need for system-level research, providing a pragmatic roadmap for building generalizable mobile manipulation systems. Videos, code, and models are available on the project website: https://arjung128.github.io/opening-articulated-structures/

cs.RO

Understanding YTHDF2-mediated mRNA Degradation By m6A-BERT-Deg

N6-methyladenosine (m6A) is the most abundant mRNA modification within mammalian cells, holding pivotal significance in the regulation of mRNA stability, translation, and splicing. Furthermore, it plays a critical role in the regulation of RNA degradation by primarily recruiting the YTHDF2 reader protein. However, the selective regulation of mRNA decay of the m6A-methylated mRNA through YTHDF2 binding is poorly understood. To improve our understanding, we developed m6A-BERT-Deg, a BERT model adapted for predicting YTHDF2-mediated degradation of m6A-methylated mRNAs. We meticulously assembled a high-quality training dataset by integrating multiple data sources for the HeLa cell line. To overcome the limitation of small training samples, we employed a pre-training-fine-tuning strategy by first performing a self-supervised pre-training of the model on 427,760 unlabeled m6A site sequences. The test results demonstrated the importance of this pre-training strategy in enabling m6A-BERT-Deg to outperform other benchmark models. We further conducted a comprehensive model interpretation and revealed a surprising finding that the presence of co-factors in proximity to m6A sites may disrupt YTHDF2-mediated mRNA degradation, subsequently enhancing mRNA stability. We also extended our analyses to the HEK293 cell line, shedding light on the context-dependent YTHDF2-mediated mRNA degradation.

q-bio.MN