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Miguel A. Hernán

Publications and source records attributed to Miguel A. Hernán.

21 records · Page 2Linked to original sources
arXiv2019

Study designs for extending causal inferences from a randomized trial to a target population

We examine study designs for extending (generalizing or transporting) causal inferences from a randomized trial to a target population. Specifically, we consider nested trial designs, where randomized individuals are nested within a sample from the target population, and non-nested trial designs, including composite dataset designs, where a randomized trial is combined with a separately obtained sample of non-randomized individuals from the target population. We show that the causal quantities that can be identified in each study design depend on what is known about the probability of sampling non-randomized individuals. For each study design, we examine identification of potential outcome means via the g-formula and inverse probability weighting. Last, we explore the implications of the sampling properties underlying the designs for the identification and estimation of the probability of trial participation.

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arXiv2019

Data science is science's second chance to get causal inference right: A classification of data science tasks

Causal inference from observational data is the goal of many data analyses in the health and social sciences. However, academic statistics has often frowned upon data analyses with a causal objective. The introduction of the term "data science" provides a historic opportunity to redefine data analysis in such a way that it naturally accommodates causal inference from observational data. Like others before, we organize the scientific contributions of data science into three classes of tasks: Description, prediction, and counterfactual prediction (which includes causal inference). An explicit classification of data science tasks is necessary to discuss the data, assumptions, and analytics required to successfully accomplish each task. We argue that a failure to adequately describe the role of subject-matter expert knowledge in data analysis is a source of widespread misunderstandings about data science. Specifically, causal analyses typically require not only good data and algorithms, but also domain expert knowledge. We discuss the implications for the use of data science to guide decision-making in the real world and to train data scientists.

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