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Miheer Dewaskar

Publications and source records attributed to Miheer Dewaskar.

8 recordsLinked to original sources

NP-LEAP: Nonparametric Latent Exchangeability Prior for Model-Lean Borrowing from Historical Data

Bayesian dynamic borrowing (BDB) methods leverage historical data to reduce treatment effect uncertainty, yet existing approaches rely on parametric outcome models susceptible to misspecification. We propose the nonparametric latent exchangeability prior (NP-LEAP), an outcome-agnostic, assumption-lean framework to borrow information from historical data. The NP-LEAP performs individual-level exchangeability assessment, inducing Bayesian model averaging over all possible partitions of the historical data into exchangeable and nonexchangeable subsets. Although applicable to a variety of data types with choice of appropriate kernel, the NP-LEAP is particularly well-suited for studies with time-to-event outcomes, where parametric BDB is potentially triply misspecified - imposing a parametric baseline hazard, the proportional hazards structure, and blanket exchangeability. We establish posterior consistency under mild regularity conditions. Simulation studies demonstrate favorable operating characteristics relative to parametric borrowing methods and nonborrowing semiparametric frequentist methods. We illustrate the method by augmenting the control arm in a randomized trial of patients with non-small cell lung cancer.

stat.ME

Bayesian Level Set Clustering

Classically, Bayesian clustering interprets each component of a mixture model as a cluster. The inferred clustering posterior is highly sensitive to any inaccuracies in the kernel within each component. As this kernel is made more flexible, problems arise in identifying the underlying clusters in the data. To address this pitfall, this article proposes a fundamentally different approach to Bayesian clustering that decouples the problems of clustering and flexible modeling of the data density $f$. Starting with an arbitrary Bayesian model for $f$ and a loss function for defining clusters based on $f$, we develop a Bayesian decision-theoretic framework for density-based clustering. Within this framework, we develop a Bayesian level set clustering method to cluster data into connected components of a level set of $f$. We provide theoretical support, including clustering consistency, and highlight performance in a variety of simulated examples. An application to astronomical data illustrates improvements over the popular DBSCAN algorithm in terms of accuracy, insensitivity to tuning parameters, and providing uncertainty quantification.

stat.ME

Robustifying likelihoods by optimistically re-weighting data

Likelihood-based inferences have been remarkably successful in wide-spanning application areas. However, even after due diligence in selecting a good model for the data at hand, there is inevitably some amount of model misspecification: outliers, data contamination or inappropriate parametric assumptions such as Gaussianity mean that most models are at best rough approximations of reality. A significant practical concern is that for certain inferences, even small amounts of model misspecification may have a substantial impact; a problem we refer to as brittleness. This article attempts to address the brittleness problem in likelihood-based inferences by choosing the most model friendly data generating process in a distance-based neighborhood of the empirical measure. This leads to a new Optimistically Weighted Likelihood (OWL), which robustifies the original likelihood by formally accounting for a small amount of model misspecification. Focusing on total variation (TV) neighborhoods, we study theoretical properties, develop estimation algorithms and illustrate the methodology in applications to mixture models and regression.

stat.ME

NExG: Provable and Guided State Space Exploration of Neural Network Control Systems using Sensitivity Approximation

We propose a new technique for performing state space exploration of closed loop control systems with neural network feedback controllers. Our approach involves approximating the sensitivity of the trajectories of the closed loop dynamics. Using such an approximator and the system simulator, we present a guided state space exploration method that can generate trajectories visiting the neighborhood of a target state at a specified time. We present a theoretical framework which establishes that our method will produce a sequence of trajectories that will reach a suitable neighborhood of the target state. We provide thorough evaluation of our approach on various systems with neural network feedback controllers of different configurations. We outperform earlier state space exploration techniques and achieve significant improvement in both the quality (explainability) and performance (convergence rate). Finally, we adopt our algorithm for the falsification of a class of temporal logic specification, assess its performance against a state-of-the-art falsification tool, and show its potential in supplementing existing falsification algorithms.

eess.SY

Finding Groups of Cross-Correlated Features in Bi-View Data

Datasets in which measurements of two (or more) types are obtained from a common set of samples arise in many scientific applications. A common problem in the exploratory analysis of such data is to identify groups of features of different data types that are strongly associated. A bimodule is a pair (A,B) of feature sets from two data types such that the aggregate cross-correlation between the features in A and those in B is large. A bimodule (A,B) is stable if A coincides with the set of features that have significant aggregate correlation with the features in B, and vice-versa. This paper proposes an iterative-testing based bimodule search procedure (BSP) to identify stable bimodules. Compared to existing methods for detecting cross-correlated features, BSP was the best at recovering true bimodules with sufficient signal, while limiting the false discoveries. In addition, we applied BSP to the problem of expression quantitative trait loci (eQTL) analysis using data from the GTEx consortium. BSP identified several thousand SNP-gene bimodules. While many of the individual SNP-gene pairs appearing in the discovered bimodules were identified by standard eQTL methods, the discovered bimodules revealed genomic subnetworks that appeared to be biologically meaningful and worthy of further scientific investigation.

stat.ME

Near Equilibrium Fluctuations for Supermarket Models with Growing Choices

We consider the supermarket model in the usual Markovian setting where jobs arrive at rate $n λ_n$ for some $λ_n > 0$, with $n$ parallel servers each processing jobs in its queue at rate 1. An arriving job joins the shortest among $d_n \le n$ randomly selected service queues. We show that when $d_n \to \infty$ and $λ_n \to λ\in (0, \infty)$, under natural conditions on the initial queues, the state occupancy process converges in probability, in a suitable path space, to the unique solution of an infinite system of constrained ordinary differential equations parametrized by $λ$. Our main interest is in the study of fluctuations of the state process about its near equilibrium state in the critical regime, namely when $λ_n \to 1$. Previous papers have considered the regime $\frac{d_n}{\sqrt{n}\log n} \to \infty$ while the objective of the current work is to develop diffusion approximations for the state occupancy process that allow for all possible rates of growth of $d_n$. In particular we consider the three canonical regimes (a) ${d_n}/{\sqrt{n}} \to 0$; (b) ${d_n}/{\sqrt{n}} \to c\in (0,\infty)$ and, (c) ${d_n}/{\sqrt{n}} \to \infty$. In all three regimes we show, by establishing suitable functional limit theorems, that (under conditions on $λ_n$) fluctuations of the state process about its near equilibrium are of order $n^{-1/2}$ and are governed asymptotically by a one dimensional Brownian motion. The forms of the limit processes in the three regimes are quite different; in the first case we get a linear diffusion; in the second case we get a diffusion with an exponential drift; and in the third case we obtain a reflected diffusion in a half space. In the special case ${d_n}/({\sqrt{n}\log n}) \to \infty$ our work gives alternative proofs for the universality results established by Mukherjee et al in 2018.

math.PR

Controlling a population

We introduce a new setting where a population of agents, each modelled by a finite-state system, are controlled uniformly: the controller applies the same action to every agent. The framework is largely inspired by the control of a biological system, namely a population of yeasts, where the controller may only change the environment common to all cells. We study a synchronisation problem for such populations: no matter how individual agents react to the actions of the controller, the controller aims at driving all agents synchronously to a target state. The agents are naturally represented by a non-deterministic finite state automaton (NFA), the same for every agent, and the whole system is encoded as a 2-player game. The first player (Controller) chooses actions, and the second player (Agents) resolves non-determinism for each agent. The game with m agents is called the m -population game. This gives rise to a parameterized control problem (where control refers to 2 player games), namely the population control problem: can Controller control the m-population game for all m in N whatever Agents does?

cs.FL

Controlling a Population

We introduce a new setting where a population of agents, each modelled by a finite-state system, are controlled uniformly: the controller applies the same action to every agent. The framework is largely inspired by the control of a biological system, namely a population of yeasts, where the controller may only change the environment common to all cells. We study a synchronisation problem for such populations: no matter how individual agents react to the actions of the controller , the controller aims at driving all agents synchronously to a target state. The agents are naturally represented by a non-deterministic finite state automaton (NFA), the same for every agent, and the whole system is encoded as a 2-player game. The first player (Controller) chooses actions, and the second player (Agents) resolves non-determinism for each agent. The game with m agents is called the m-population game. This gives rise to a parameterized control problem (where control refers to 2 player games), namely the population control problem: can Controller control the m-population game for all $m $\in$ N$ whatever Agents does? In this paper, we prove that the population control problem is decidable, and it is a EXPTIME-complete problem. As far as we know, this is one of the first results on parameterized control. Our algorithm, not based on cutoff techniques, produces winning strategies which are symbolic, that is, they do not need to count precisely how the population is spread between states. We also show that if there is no winning strategy, then there is a population size M such that Controller wins the m-population game if and only if $m $\le$ M$. Surprisingly, M can be doubly exponential in the number of states of the NFA, with tight upper and lower bounds.

cs.FL