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Mijeong Kim

Publications and source records attributed to Mijeong Kim.

11 recordsLinked to original sources

Variance-Aware Estimation and Inference for Michaelis--Menten Models with Heteroscedastic Errors and Clustered Measurements

Michaelis--Menten analysis is often conducted by nonlinear least squares under a constant-variance assumption, even though enzyme-kinetic data frequently display concentration-dependent heteroscedasticity and often include repeated or clustered measurements. We develop a variance-aware procedure for Michaelis--Menten estimation and inference that is motivated by conditional moment restrictions and implemented through simple conditionally Gaussian working models. For single curves, the method reduces to one-dimensional root finding for $K_m$ followed by closed-form plug-in updates for $V_{\max}$ and a variance scale parameter; the same score logic yields a cluster-level extension through a random-effect-induced working covariance. In simulation, modeling heteroscedasticity improved variance recovery and interval efficiency relative to homoscedastic nonlinear least squares, while cluster-aware semiparametric and NLME fits restored fixed-effect coverage far more effectively than pooled analyses that ignored clustering. In self-driving laboratory and soil exoenzyme data, heteroscedastic models achieved lower information criteria than homoscedastic nonlinear least squares, with the square-root variance function giving the most stable empirical fit among the prespecified working models. We implement the workflow in the companion \texttt{inferMM} package for single-curve, grouped, and clustered Michaelis--Menten analysis. These results show that simple variance-function and covariance modeling can stabilize original-scale Michaelis--Menten inference when variability changes with substrate concentration or measurements are clustered.

stat.ME

Research trends in music-based interventions in neonatal intensive care units: a text mining and topic modeling study

Background: Music-based interventions are increasingly used in neonatal intensive care units (NICUs), but the literature remains heterogeneous in intervention type, provider role, and research focus. This study examined research trends in NICU music-based intervention studies using text mining. Methods: We analyzed 83 abstracts from peer-reviewed studies published between 1998 and 2025. Methods included preprocessing, RAKE-based keyphrase extraction, keyword frequency analysis, temporal trend analysis, intervention-type comparison, and latent Dirichlet allocation topic modeling. The optimal number of topics was determined using the CaoJuan2009, Arun2010, and Deveaud2014 metrics. Results: Study volume increased steadily over time, with nearly half (38/83) published from 2020 onward. Early studies focused on passive music listening and short-term physiological outcomes, whereas recent studies increasingly examined singing, live music, and parent-involved interventions. Keyword analysis showed a shift from physiological stability and behavioral responses toward neurodevelopmental outcomes, parental emotional well-being, and parent-infant interaction. Music medicine studies emphasized passive auditory stimulation and immediate physiological outcomes, whereas music therapy studies addressed broader developmental, relational, and psychosocial topics. Topic modeling identified four major themes, with parent-involved physiological regulation and stress reduction the most frequent dominant topic. Conclusions: NICU music-based intervention research is becoming more interdisciplinary. The field has expanded from immediate physiological stabilization to broader developmental, relational, and psychosocial goals. Future work should clarify the distinction between music therapy and music medicine and promote interdisciplinary collaboration in NICU care.

stat.AP

Structured Semiparametric Estimation of Average Treatment Effects with Treatment-Specific Non-Gaussian Error Distributions

This paper studies average treatment effect (ATE) estimation for continuous outcomes when the treatment-covariate mean is structured but the error distributions are unknown and may differ across treatment arms in scale, skewness, or tail behavior. We introduce a semiparametric model with a finite-dimensional mean, or a prespecified basis expansion, and separate unrestricted additive error laws for treated and control outcomes. The central theoretical contribution is the ATE-efficient influence function under two treatment-specific error nuisance spaces: it combines arm-specific regression-efficient scores with variation in the marginal covariate law and is distinct from both the unrestricted AIPW gradient and a pooled location-shift score. We establish the exact nested ordering of the efficiency bounds under pooled common-error, treatment-specific-error, and unrestricted causal models, including equality conditions. A local-misspecification result further shows that the variance reduction obtained by valid pooling equals the maximal squared first-order bias incurred along unit treatment-specific directions excluded by the pooled model. We develop efficient cross-fitted plug-in and ATE-targeted implementations requiring only two one-dimensional density estimates; the targeted refinement adds a scalar update. Simulations show substantial precision gains from valid pooling under common non-Gaussian errors and protection against invalid pooling when treatment changes error shape, including under weak positivity. Applications to ACTG175 and National Supported Work data illustrate the resulting precision--robustness tradeoff for irregular continuous outcomes.

stat.ME

Semiparametric Causal Mediation Analysis for Linear Models with Non-Gaussian Errors: Applications to Drug Treatment and Social Program Evaluation

\textbf{Background:} Mediation analysis is widely used to investigate how treatments and programs exert their effects, but standard ordinary least squares (OLS) inference can be unreliable when regression errors are non-Gaussian. In medical and public-health studies, this can affect whether indirect and direct effects are judged clinically or scientifically meaningful. \textbf{Methods:} We developed a semiparametric causal mediation framework for linear models allowing possibly non-Gaussian errors, covering both standard models and models with treatment--mediator interaction. The method combines semiparametric efficient regression estimation, a reproducible multi-start fitting algorithm for numerical stability, and stacked estimating equations for confidence-interval construction without requiring Gaussian error assumptions. \textbf{Results:} Across Gaussian, skewed, and mixture-error simulations, the semiparametric estimator reduced root mean squared error and confidence-interval length relative to OLS, with the largest gains under non-Gaussian errors. In a near-boundary power design, the OLS confidence interval achieved 18.3\% empirical power, whereas the semiparametric confidence interval identified significant effects in all replications. In the \textit{uis} drug-treatment data, it yielded sharper treatment-specific effect estimates under clear treatment--mediator interaction. In the \textit{jobs} social-program data, the semiparametric analysis produced shorter confidence intervals for mediated effects and detected nonzero mediation where OLS did not. \textbf{Conclusions:} Semiparametric mediation analysis can improve the precision and reliability of effect decomposition in studies with non-Gaussian outcomes, offering a practical alternative to OLS when indirect and direct effects may inform clinical or policy decision-making.

stat.ME

GP-4DGS: Probabilistic 4D Gaussian Splatting from Monocular Video via Variational Gaussian Processes

We present GP-4DGS, a novel framework that integrates Gaussian Processes (GPs) into 4D Gaussian Splatting (4DGS) for principled probabilistic modeling of dynamic scenes. While existing 4DGS methods focus on deterministic reconstruction, they are inherently limited in capturing motion ambiguity and lack mechanisms to assess prediction reliability. By leveraging the kernel-based probabilistic nature of GPs, our approach introduces three key capabilities: (i) uncertainty quantification for motion predictions, (ii) motion estimation for unobserved or sparsely sampled regions, and (iii) temporal extrapolation beyond observed training frames. To scale GPs to the large number of Gaussian primitives in 4DGS, we design spatio-temporal kernels that capture the correlation structure of deformation fields and adopt variational Gaussian Processes with inducing points for tractable inference. Our experiments show that GP-4DGS enhances reconstruction quality while providing reliable uncertainty estimates that effectively identify regions of high motion ambiguity. By addressing these challenges, our work takes a meaningful step toward bridging probabilistic modeling and neural graphics.

cs.CV

PhysGaia: A Physics-Aware Benchmark with Multi-Body Interactions for Dynamic Novel View Synthesis

We introduce PhysGaia, a novel physics-aware benchmark for Dynamic Novel View Synthesis (DyNVS) that encompasses both structured objects and unstructured physical phenomena. While existing datasets primarily focus on photorealistic appearance, PhysGaia is specifically designed to support physics-consistent dynamic reconstruction. Our benchmark features complex scenarios with rich multi-body interactions, where objects realistically collide and exchange forces. Furthermore, it incorporates a diverse range of materials, including liquid, gas, textile, and rheological substance, moving beyond the rigid-body assumptions prevalent in prior work. To ensure physical fidelity, all scenes in PhysGaia are generated using material-specific physics solvers that strictly adhere to fundamental physical laws. We provide comprehensive ground-truth information, including 3D particle trajectories and physical parameters (e.g., viscosity), enabling the quantitative evaluation of physical modeling. To facilitate research adoption, we also provide integration pipelines for recent 4D Gaussian Splatting models along with our dataset and their results. By addressing the critical shortage of physics-aware benchmarks, PhysGaia can significantly advance research in dynamic view synthesis, physics-based scene understanding, and the integration of deep learning with physical simulation, ultimately enabling more faithful reconstruction and interpretation of complex dynamic scenes.

cs.GR

4D Gaussian Splatting in the Wild with Uncertainty-Aware Regularization

Novel view synthesis of dynamic scenes is becoming important in various applications, including augmented and virtual reality. We propose a novel 4D Gaussian Splatting (4DGS) algorithm for dynamic scenes from casually recorded monocular videos. To overcome the overfitting problem of existing work for these real-world videos, we introduce an uncertainty-aware regularization that identifies uncertain regions with few observations and selectively imposes additional priors based on diffusion models and depth smoothness on such regions. This approach improves both the performance of novel view synthesis and the quality of training image reconstruction. We also identify the initialization problem of 4DGS in fast-moving dynamic regions, where the Structure from Motion (SfM) algorithm fails to provide reliable 3D landmarks. To initialize Gaussian primitives in such regions, we present a dynamic region densification method using the estimated depth maps and scene flow. Our experiments show that the proposed method improves the performance of 4DGS reconstruction from a video captured by a handheld monocular camera and also exhibits promising results in few-shot static scene reconstruction.

cs.CV

Generative Neural Fields by Mixtures of Neural Implicit Functions

We propose a novel approach to learning the generative neural fields represented by linear combinations of implicit basis networks. Our algorithm learns basis networks in the form of implicit neural representations and their coefficients in a latent space by either conducting meta-learning or adopting auto-decoding paradigms. The proposed method easily enlarges the capacity of generative neural fields by increasing the number of basis networks while maintaining the size of a network for inference to be small through their weighted model averaging. Consequently, sampling instances using the model is efficient in terms of latency and memory footprint. Moreover, we customize denoising diffusion probabilistic model for a target task to sample latent mixture coefficients, which allows our final model to generate unseen data effectively. Experiments show that our approach achieves competitive generation performance on diverse benchmarks for images, voxel data, and NeRF scenes without sophisticated designs for specific modalities and domains.

cs.LG

ContraNeRF: 3D-Aware Generative Model via Contrastive Learning with Unsupervised Implicit Pose Embedding

Although 3D-aware GANs based on neural radiance fields have achieved competitive performance, their applicability is still limited to objects or scenes with the ground-truths or prediction models for clearly defined canonical camera poses. To extend the scope of applicable datasets, we propose a novel 3D-aware GAN optimization technique through contrastive learning with implicit pose embeddings. To this end, we first revise the discriminator design and remove dependency on ground-truth camera poses. Then, to capture complex and challenging 3D scene structures more effectively, we make the discriminator estimate a high-dimensional implicit pose embedding from a given image and perform contrastive learning on the pose embedding. The proposed approach can be employed for the dataset, where the canonical camera pose is ill-defined because it does not look up or estimate camera poses. Experimental results show that our algorithm outperforms existing methods by large margins on the datasets with multiple object categories and inconsistent canonical camera poses.

cs.CV

Appropriate use of parametric and nonparametric methods in estimating regression models with various shapes of errors

In this paper, a practical estimation method for a regression model is proposed using semiparametric efficient score functions applicable to data with various shapes of errors. First, I derive semiparametric efficient score vectors for a homoscedastic regression model without any assumptions of errors. Next, the semiparametric efficient score function can be modified assuming a certain parametric distribution of errors according to the shape of the error distribution or by estimating the error distribution non-parametrically. Nonparametric methods for errors can be used to estimate the parameters of interest or to find an appropriate parametric error distribution. In this regard, the proposed estimation methods utilize both parametric and nonparametric methods for errors appropriately. Through numerical studies, the performance of the proposed estimation methods is demonstrated.

stat.ME

InfoNeRF: Ray Entropy Minimization for Few-Shot Neural Volume Rendering

We present an information-theoretic regularization technique for few-shot novel view synthesis based on neural implicit representation. The proposed approach minimizes potential reconstruction inconsistency that happens due to insufficient viewpoints by imposing the entropy constraint of the density in each ray. In addition, to alleviate the potential degenerate issue when all training images are acquired from almost redundant viewpoints, we further incorporate the spatially smoothness constraint into the estimated images by restricting information gains from a pair of rays with slightly different viewpoints. The main idea of our algorithm is to make reconstructed scenes compact along individual rays and consistent across rays in the neighborhood. The proposed regularizers can be plugged into most of existing neural volume rendering techniques based on NeRF in a straightforward way. Despite its simplicity, we achieve consistently improved performance compared to existing neural view synthesis methods by large margins on multiple standard benchmarks.

cs.CV