arXiv subjects

Mikael Lassen

Publications and source records attributed to Mikael Lassen.

At least 19 recordsLinked to original sources

arXiv2026

Broadly tunable quantum-enhanced Raman microscopy for advancing bioimaging

Stimulated Raman scattering (SRS) microscopy has emerged as a powerful technique for probing the spatiotemporal dynamics of molecular bonds with exceptional sensitivity, resolution, and speed. However, classically, its performance remains fundamentally constrained by optical shot noise, which imposes a strict limit on detection sensitivity and speed. Here, we demonstrate a quantum-enhanced SRS microscopy platform that circumvents this barrier by harnessing amplitude-squeezed light. Specifically, we generate a Stokes beam with $5.2~\mathrm{dB}$ of amplitude squeezing using traveling-wave optical parametric amplification in second-order nonlinear waveguides, and combine it with a tunable coherent pump to access vibrational modes spanning from $1000$ to $3100~\mathrm{cm}^{-1}$. Applied to quantum imaging of metabolites in biological tissue (pork muscle), our quantum-enhanced Raman microscope achieves an average noise suppression of $3.6~\mathrm{dB}$ and a $51\%$ enhancement in signal-to-noise ratio (SNR) -- to the best of our knowledge, the largest improvement reported to date in quantum-enhanced SRS microscopy of biological samples.

physics.optics↗

arXiv2026

Quantifying Effective Heterodyne Detection Efficiency with SI-Traceable Standards

Accurate calibration of coherent optical receivers is essential for reliable performance assessment in coherent communications, precision and quantum sensing, and continuous-variable quantum key distribution (CV-QKD), where the effective detection efficiency directly impacts channel parameter estimation. We present a methodology traceable to the International System of Units (SI) to determine the effective heterodyne detection efficiency of balanced receivers using shot-noise-referenced measurements. The protocol relies on two observables acquired with an electrical spectrum analyzer: the heterodyne beat-note power and the local oscillator shot-noise variance, with explicit treatment of the analyzer's equivalent noise bandwidth (ENBW). The photon flux in the signal path is referenced to SI units via calibrated radiometric standards. We first validate the protocol on a free-space receiver, demonstrating consistency with an independently constructed optical loss chain across a wide range of signal powers and under controlled, calibrated attenuation. Extending the same estimator to a fiber-coupled, polarization-maintaining balanced receiver confirms that the protocol is robust for practical coherent-receiver architectures and intermediate frequencies in the MHz range. These results establish a traceable, uncertainty-bounded framework for real-time receiver calibration, providing a practical route for CV-QKD and other coherent optical systems.

quant-ph↗

arXiv2025

Hyper-spectral Imaging with Up-Converted Mid-Infrared Single-Photons

Hyperspectral imaging in the mid-infrared (MIR) spectral range provides unique molecular specificity by probing fundamental vibrational modes of molecular bonds, making it highly valuable for biomedical and biochemical applications. However, conventional MIR imaging techniques often rely on high-intensity illumination that can induce photodamage in sensitive biological tissues. Single-photon MIR imaging offers a label-free, non-invasive alternative, yet its adoption is hindered by the lack of efficient, room-temperature MIR single-photon detectors. We present a single-photon hyperspectral imaging platform that combines cavity-enhanced spontaneous parametric down-conversion (SPDC) with nonlinear frequency up-conversion. This approach enables MIR spectral imaging using cost-effective, visible-wavelength silicon single-photon avalanche diodes (Si-SPADs), supporting room-temperature, low-noise, and high-efficiency operation. Time-correlated photon pairs generated via SPDC suppress classical intensity noise, enabling near shot-noise-limited hyperspectral imaging. We demonstrate chemically specific single-photon imaging across the \SIrange{2.9}{3.6}{\micro\meter} range on biological (egg yolk, yeast) and polymeric (polystyrene, polyethylene) samples. The system delivers high-contrast, label-free imaging at ultralow photon flux, overcoming key limitations of current MIR technologies. This platform paves the way toward scalable, quantum-enabled MIR imaging for applications in molecular diagnostics, environmental sensing, and biomedical research.

quant-ph↗

arXiv2022

Accurate and fast identification of minimally prepared bacteria phenotypes using Raman spectroscopy assisted by machine learning

The worldwide increase of antimicrobial resistance (AMR) is a serious threat to human health. To avert the spread of AMR, fast reliable diagnostics tools that facilitate optimal antibiotic stewardship are an unmet need. In this regard, Raman spectroscopy promises rapid label- and culture-free identification and antimicrobial susceptibility testing (AST) in a single step. However, even though many Raman-based bacteria-identification and AST studies have demonstrated impressive results, some shortcomings must be addressed. To bridge the gap between proof-of-concept studies and clinical application, we have developed machine learning techniques in combination with a novel data-augmentation algorithm, for fast identification of minimally prepared bacteria phenotypes and the distinctions of methicillin-resistant (MR) from methicillin-susceptible (MS) bacteria. For this we have implemented a spectral transformer model for hyper-spectral Raman images of bacteria. We show that our model outperforms the standard convolutional neural network models on a multitude of classification problems, both in terms of accuracy and in terms of training time. We attain more than 96$\%$ classification accuracy on a dataset consisting of 15 different classes and 95.6$\%$ classification accuracy for six MR-MS bacteria species. More importantly, our results are obtained using only fast and easy-to-produce training and test data

cs.LG↗

arXiv2021

Two-colour high-purity Einstein-Podolsky-Rosen photonic state

Entanglement is the backbone of quantum information science and its applications. Entangled states of light are necessary for distributed quantum protocols, quantum sensing and quantum internet. A distributed quantum network requires entanglement between light modes of different colours optimized for interaction with the nodes as well as for communication between them. Here we demonstrate a high-purity Einstein-Podolsky-Rosen (EPR) entangled state between light modes with the wavelengths separated by more than 200 nm. The modes display $-7.7\pm0.5$ dB of two-mode entanglement and an overall state purity of $0.63\pm0.16$. Entanglement is observed over five octaves of sideband frequencies from rf down to audio-band. In the context of two-colour entanglement, the demonstrated combination of high state purity, strong entanglement, and extended frequency range paves the way to new matter-light quantum protocols, such as teleportation between disparate quantum systems, quantum sensing and quantum-enhanced gravitational wave interferometry. The scheme demonstrated here can be readily applied towards entanglement between telecom wavelengths and atomic quantum memories.

quant-ph↗

arXiv2021

Quantum frequency conversion of vacuum squeezed light to bright tunable blue squeezed light and higher-order spatial modes

Quantum frequency conversion, the process of shifting the frequency of an optical quantum state while preserving quantum coherence, can be used to produce non-classical light at otherwise unapproachable wavelengths. We present experimental results based on highly efficient sum-frequency generation (SFG) between a vacuum squeezed state at 1064 nm and a tunable pump source at 850 nm $\pm$ 50 nm for the generation of bright squeezed light at 472~nm $\pm$ 4~nm, currently limited by the phase-matching of the used nonlinear crystal. We demonstrate that the SFG process conserves part of the quantum coherence as a 4.2($\pm0.2$)~dB 1064 nm vacuum squeezed state is converted to a 1.6($\pm$0.2)~dB tunable bright blue squeezed state. We furthermore demonstrate simultaneous frequency- and spatial-mode conversion of the 1064-nm vacuum squeezed state, and measure 1.1($\pm$0.2)~dB and 0.4($\pm$0.2)~dB of squeezing in the TEM$_{01}$ and TEM$_{02}$ modes, respectively. With further development, we foresee that the source may find use within fields such as sensing, metrology, spectroscopy, and imaging.

quant-ph↗

arXiv2021

Cavity-enhanced sum-frequency generation of blue light with near-unity conversion efficiency

We report on double-resonant highly efficient sum-frequency generation in the blue range. The system consists of a 10-mm-long periodically poled KTP crystal placed in a double-resonant bow-tie cavity and pumped by a fiber laser at 1064.5 nm and a Ti:sapphire laser at 849.2 nm. An optical power of 375 mW at 472.4 nm in a TEM$_{00}$ mode was generated with pump powers of 250 mW at 849.2 nm and 200 mW at 1064.5 nm coupled into the double-resonant ring resonator with 88$\%$ mode-matching. The resulting internal conversion efficiency of 95($\pm 3$)$\%$ of the photons mode-matched to the cavity constitutes, to the best of our knowledge, the highest overall achieved quantum conversion efficiency using continuous-wave pumping. Very high conversion efficiency is rendered possible due to very low intracavity loss on the level of 0.3$\%$ and high nonlinear conversion coefficient up to 0.045(0.015) W$^{-1}$. Power stability measurements performed over one hour show a stability of 0.8$\%$. The generated blue light can be tuned within 5 nm around the center wavelength of 472.4 nm, limited by the phase-matching of our nonlinear crystal. This can however be expanded to cover the entire blue spectrum (420 nm to 510 nm) by proper choice of nonlinear crystals and pump lasers. Our experimental results agree very well with analytical and numerical simulations taking into account cavity impedance matching and depletion of the pump fields.

physics.optics↗

arXiv2020

Continuous-wave coherent Raman spectroscopy for improving the accuracy of Raman shifts

Raman spectroscopy is an appealing technique that probes molecular vibrations in a wide variety of materials with virtually no sample preparation. However, accurate and reliable Raman measurements are still a challenge and require more robust and practical calibration methods. We demonstrate the implementation of a simple low-cost continuous-wave stimulated Raman spectroscopy scheme for accurate and high-resolution spectroscopy. We perform shot noise limited continuous-wave stimulated Raman scattering (cwSRS) as well as continuous-wave coherent anti-Stokes Raman scattering (cwCARS) on polystyrene samples. Our method enables accurate determination of Raman shifts with an uncertainty below 0.1 cm$^{-1}$. The setup is used for the characterization of reference materials required for the calibration of Raman spectrometers. Compared with existing standards, we provide an order of magnitude improvement of the uncertainty of Raman energy shifts in a polystyrene reference material.

physics.optics↗

arXiv2019

Simple and robust speckle detection method for fire and heat detection in harsh environments

Standard laser based fire detection systems are often based on measuring variation of optical signal amplitude. However, mechanical noise interference and loss from dust and steam can obscure the detection signal, resulting in faulty results or inability to detect a potential fire. The presented fire detection technology will allow the detection of fire in harsh and dusty areas, which are prone to fires, where current systems show limited performance or are unable to operate. It is not the amount of light nor its wavelength that is used for detecting fire, but how the refractive index randomly fluctuates due to the heat convection from the fire. In practical terms this means that light obstruction from ambient dust particles will not be a problem as long as a small fraction of the light is detected and that fires without visible flames can still be detected. The standalone laser system consists of a Linux-based Red Pitaya system, a cheap 650 nm laser diode, and a PIN photo-detector. Laser light propagates through the monitored area and reflects off a retroreflector generating a speckle pattern. Every 3 seconds time traces and frequency noise spectra are measured and 8 descriptors are deduced to identify a potential fire. Both laboratory and factory acceptance tests have been performed with success.

physics.app-ph↗

arXiv2018

Versatile photoacoustic spectrometer based on a mid-infrared pulsed optical parametric oscillator

We demonstrate the usefulness of a nanosecond pulsed single-mode mid-infrared (MIR) optical parametric oscillator (OPO) for Photoacoustic (PA) spectroscopic measurements. The maximum wavelength ranges for the signal and idler are 1.4 um to 1.7 um and 2.8 um to 4.6 um, respectively, and with a MIR output power of up to 500 mW. Making the OPO useful for different spectroscopic PA trace-gas measurements targeting the major market opportunity of environmental monitoring and breath gas analysis. We perform spectroscopic measurements of methane (CH4) nitrogen dioxide (NO2) and ammonia (NH3) in the 2.8 um to 3.7 um wavelength region. The measurements were conducted with a constant flow rate of 300 ml/min, thus demonstrating the suitability of the gas sensor for real time trace gas measurements. The acquired spectra are compared with data from the Hitran database and good agreement is found. Demonstrating a resolution bandwidth of 1.5 1/cm. An Allan deviation analysis shows that the detection limit for methane at optimum integration time for the PA sensor is 8 ppbV (nmol/mol) at 105 seconds of integration time.

physics.app-ph↗

arXiv2018

Designing and experimental verification of a photoacoustic flow sensor using computational fluid dynamics

A photoacoustic (PA) sensor for fast and real-time gas sensing is demonstrated. The PA sensor is a standalone system controlled by a Field-Programmable Gate Array (FPGA). The PA cell has been designed for flow noise immunity using computational fluid dynamics (CFD) analysis. The aim of the CFD analysis was to investigate and minimize the influence of the gas distribution and the flow noise on the PA signal. PA measurements were conducted at different flow rates by exciting molecular C-H stretch vibrational bands of hexane (C$_6$H$_{14}$) and decane (C$_{10}$H$_{22}$) molecules in clean air at 2950 cm$^{-1}$ (3.38 $μ$m) with a custom made mid-infrared interband cascade laser (ICL). We observe a (1$σ$, standard deviation) sensitivity of 0.4 $\pm0.1$ ppb (nmol/mol) for hexane in clean air at flow rates up to 1.7 L/min, corresponding to a normalized noise equivalent absorption (NNEA) coefficient of 2.5$\times 10^{-9}$ W cm$^{-1}$ Hz$^{-1/2}$, demonstrating high sensitivity and fast real-time gas analysis. An Allan deviation analysis for decane shows that the detection limit at optimum integration time is 0.25 ppbV (nmol/mol).

physics.ins-det↗

arXiv2017

Photoacoustic spectroscopy of NO$_2$ using a mid-infrared pulsed optical parametric oscillator as light source

A photoacoustic (PA) sensor for spectroscopic measurements of NO$_2$-N$_2$ at ambient pressure and temperature is demonstrated. The PA sensor is pumped resonantly by a nanosecond pulsed single-mode mid-infrared (MIR) optical parametric oscillator (OPO). Spectroscopic measurements of NO$_2$-N$_2$ in the 3.25 $μ$m to 3.55 $μ$m wavelength region with a resolution bandwidth of 5 cm$^{-1}$ and with a single shot detection limit of 1.6 ppmV ($μ$mol/mol) is demonstrated. The measurements were conducted with a constant flow rate of 300 ml/min, thus demonstrating the suitability of the gas sensor for real time trace gas measurements. The acquired spectra is compared with data from the Hitran database and good agreement is found. An Allan deviation analysis shows that the detection limit at optimum integration time for the PAS sensor is 14 ppbV (nmol/mol) at 170 seconds of integration time, corresponding to a normalized noise equivalent absorption (NNEA) coefficient of 3.3$\times 10^{-7}$ W cm$^{-1}$ Hz$^{-1/2}$.

physics.app-ph↗

arXiv2017

Quartz-enhanced photoacoustic spectroscopy as a platform for non-invasive trace gas analyser targeting breath analysis

An innovative and novel quartz-enhanced photoacoustic spectroscopy (QEPAS) sensor for highly sensitive and selective breath gas analysis is introduced. The QEPAS sensor consists of two acoustically coupled micro-resonators (mR) with an off-axis 20 kHz quartz tuning fork (QTF). The complete acoustically coupled mR system is optimized based on finite element simulations and experimentally verified. Due to the very low fabrication costs the QEPAS sensor presents a clear breakthrough in the field of photoacoustic spectroscopy by introducing novel disposable gas chambers in order to avoid cleaning after each test. The QEPAS sensor is pumped resonantly by a nanosecond pulsed single-mode mid-infrared optical parametric oscillator (MIR OPO). Spectroscopic measurements of methane and methanol in the 3.1 $μ$m to 3.7 $μ$m wavelength region is conducted. Demonstrating a resolution bandwidth of 1 cm$^{-1}$. An Allan deviation analysis shows that the detection limit at optimum integration time for the QEPAS sensor is 32 ppbv@190s for methane and that the background noise is solely due to the thermal noise of the QTF. Spectra of both individual molecules as well as mixtures of molecules were measured and analyzed. The molecules are representative of exhaled breath gasses that are bio-markers for medical diagnostics.

physics.ins-det↗

arXiv2017

Compact and versatile laser system for polarization-sensitive stimulated Raman spectroscopy

We demonstrate a compact and versatile laser system for stimulated Raman spectroscopy (SRS). The system is based on a tunable continuous wave (CW) probe laser combined with a home-built semi-monolithic nanosecond pulsed pump Nd:YVO4 laser at 1064 nm. The CW operation of the probe laser offers narrow linewidth, low noise and the advantage that temporal synchronization with the pump is not required. The laser system enables polarization-sensitive stimulated Raman spectroscopy (PS-SRS) with fast high resolution measurement of the depolarization ratio by simultaneous detection of Raman scattered light in orthogonal polarizations, thus providing information about the symmetry of the Raman-active vibrational modes. Measurements of the depolarization ratios of the carbon-hydrogen (CH) stretching modes in two different polymer samples in the spectral range of 2825-3025 cm-1 were performed. Raman spectra are obtained at a sweep rate of 20 nm/s (84 cm-1/s) with a resolution of 0.65 cm-1. A normalization method is introduced for the direct comparison of the simultaneously acquired orthogonal polarized Raman spectra.

physics.chem-ph↗

arXiv2016

Photo-acoustic sensor for detection of oil contamination in compressed air systems

We demonstrate an online (in-situ) sensor for continuous detection of oil contamination in compressed air systems complying with the ISO-8573 standard. The sensor is based on the photo-acoustic (PA) effect. The online and real-time PA sensor system has the potential to benefit a wide range of users that require high purity compressed air. Among these are hospitals, pharmaceutical industries, electronics manufacturers, and clean room facilities. The sensor was tested for sensitivity, repeatability, robustness to molecular cross-interference, and stability of calibration. Explicit measurements of hexane (C${_6}$H$_{14}$) and decane (C${_{10}}$H$_{22}$) vapors via excitation of molecular C-H vibrations at approx. 2950 cm$^{-1}$ (3.38 $μ$m) were conducted with a custom made interband cascade laser (ICL). For the decane measurements a (1 $σ$) standard deviation (STD) of 0.3 ppb was demonstrated, which corresponds to a normalized noise equivalent absorption (NNEA) coefficient for the prototype PA sensor of 2.8$\times 10^{-9}$ W cm$^{-1}$ Hz$^{1/2}$.

physics.ins-det↗

arXiv2016

All-Optical Detection of Acoustic Pressure Waves with applications in Photo-Acoustic Spectroscopy

An all-optical detection method for the detection of acoustic pressure waves is demonstrated. The detection system is based on a stripped (bare) single-mode fiber. The fiber vibrates as a standard cantilever and the optical output from the fiber is imaged to a displacement-sensitive optical detector. The absence of a conventional microphone makes the demonstrated system less susceptible to the effects that a hazardous environment might have on the sensor. The sensor is also useful for measurements in high temperature (above $200^{\circ}$C) environments where conventional microphones will not operate. The proof-of-concept of the all-optical detection method is demonstrated by detecting sound waves generated by the photo-acoustic effect of NO$_2$ excited by a 455 nm LED, where a detection sensitivity of approximately 50 ppm was achieved.

physics.ins-det↗

arXiv2016

Off-axis QEPAS using a pulsed nanosecond Mid-Infrared Optical Parametric Oscillator

A trace gas sensor, based on quartz-enhanced photoacoustic spectroscopy (QEPAS), consisting of two acoustically coupled micro-resonators (mR) with an off-axis 20 kHz quartz tuning fork (QTF) is demonstrated. The complete acoustically coupled mR system is optimized based on finite element simulations and experimentally verified. The QEPAS sensor is pumped resonantly by a nanosecond pulsed single-mode mid-infrared optical parametric oscillator (MIR OPO). The sensor is used for spectroscopic measurements on methane in the 3.1 um to 3.5 um wavelength region with a resolution bandwidth of 1 cm^-1 and a detection limit of 0.8 ppm. An Allan deviation analysis shows that the detection limit at optimum integration time for the QEPAS sensor is 32 ppbv@190s and that the background noise is solely due to the thermal noise of the QTF.

physics.ins-det↗

arXiv2015

Differential high-resolution stimulated CW Raman spectroscopy of hydrogen in a hollow-core fiber

We demonstrate sensitive high-resolution stimulated Raman measurements of hydrogen using a hollow-core photonic crystal fiber (HC-PCF). The Raman transition is pumped by a narrow linewidth (<50 kHz) 1064 nm continuous-wave (CW) fiber laser. The probe light is produced by a homebuilt CW optical parametric oscillator (OPO), tunable from around 800 nm to 1300 nm (linewidth ~ 5 MHz). These narrow linewidth lasers allow for an excellent spectral resolution of approximately 10^-4 cm^(-1). The setup employs a differential measurement technique for noise rejection in the probe beam, which also eliminates background signals from the fiber. With the high sensitivity obtained, Raman signals were observed with only a few mW of optical power in both the pump and probe beams. This demonstration allows for high resolution Raman identification of molecules and quantification of Raman signal strengths.

physics.optics↗