arXiv subjects

Milad Lankarany

Publications and source records attributed to Milad Lankarany.

11 recordsLinked to original sources

arXiv2026

Calibration-Free Cuffless Blood Pressure Estimation Using Multimodal ECG-PPG Fusion on a Google Pixel Watch

Inadequate blood pressure (BP) monitoring and management outside of clinical settings can worsen major cardiovascular risk factors such as hypertension. While cuff-based devices are commonly used for at-home monitoring, these devices can be inconvenient for daily use due to their sensitivity to body positions, upper-arm constrictions, and limited portability. A promising alternative is emerging in the form of consumer-grade smartwatches, where physiological signals related to cardiac activity can be used to estimate BP non-invasively and continuously across daily living conditions. In this work, we use data collected from a Google Pixel Watch in 40 participants to develop and compare several algorithm approaches for BP estimation. We found that our proposed deep learning model achieved the strongest overall performance, and that fusing smartwatch signals with demographic information improved model generalizability to unseen individuals. However, we also identified that model accuracy was not consistent across participant subgroups, with obese individuals yielding higher estimation errors than others. This study highlights the feasibility of consumer-grade smartwatches as accessible platforms for deploying robust BP estimation algorithms, though clinical reliability will require larger, more diverse populations and additional sensing modalities.

cs.HC↗

arXiv2025

HEART-Watch: A multimodal physiological dataset from a Google Pixel Watch across different physical states

Consumer-grade smartwatches offer a new option for personalized health monitoring for general consumers, as cardiovascular diseases continue to prevail as the leading cause of global mortality. The development and validation of reliable cardiovascular monitoring algorithms for these consumer-grade devices requires realistic biosignal data from diverse sets of participants. However, the availability of public consumer-grade smartwatch datasets with synchronized cardiovascular biosignals remains limited, and existing datasets often lack rich demographic diversity in their participant cohorts, potentially leading to biased algorithm development. This paper presents HEART-Watch, a multimodal physiological dataset of synchronized wrist-worn Google Pixel Watch electrocardiogram (ECG), photoplethysmography, and accelerometer signals from a diverse cohort of 40 healthy adults across three physical states - sitting, standing and walking - alongside reference chest ECG. Intermittent upper arm blood pressure measurements and concurrent biosignals were collected as an additional biomarker for future research. The motivation, methodology, and initial analyses of results are presented. HEART-Watch is intended to support the development and benchmarking of robust cardiovascular algorithms on consumer-grade smartwatches across diverse populations.

cs.HC↗

arXiv2025

Classifying Clinical Outcome of Epilepsy Patients with Ictal Chirp Embeddings

This study presents a pipeline leveraging t-Distributed Stochastic Neighbor Embedding (t-SNE) for interpretable visualizations of chirp features across diverse outcome scenarios. The dataset, comprising chirp-based temporal, spectral, and frequency metrics. Using t-SNE, local neighborhood relationships were preserved while addressing the crowding problem through Student t-distribution-based similarity optimization. Three classification tasks were formulated on the 2D t-SNE embeddings: (1) distinguishing clinical success from failure/no-resection, (2) separating high-difficulty from low-difficulty cases, and (3) identifying optimal cases, defined as successful outcomes with minimal clinical difficulty. Four classifiers, namely, Random Forests, Support Vector Machines, Logistic Regression, and k-Nearest Neighbors, were trained and evaluated using stratified 5-fold cross-validation. Across tasks, the Random Forest and k-NN classifiers demonstrated superior performance, achieving up to 88.8% accuracy in optimal case detection (successful outcomes with minimal clinical difficulty). Additionally, feature influence sensitivity maps were generated using SHAP explanations applied to model predicting t-SNE coordinates, revealing spatially localized feature importance within the embedding space. These maps highlighted how specific chirp attributes drive regional clustering and class separation, offering insights into the latent structure of the data. The integrated framework showcases the potential of interpretable embeddings and local feature attribution for clinical stratification and decision support.

cs.LG↗

arXiv2025

Semi-Supervised Anomaly Detection Pipeline for SOZ Localization Using Ictal-Related Chirp

This study presents a quantitative framework for evaluating the spatial concordance between clinically defined seizure onset zones (SOZs) and statistically anomalous channels identified through time-frequency analysis of chirp events. The proposed pipeline employs a two-step methodology: (1) Unsupervised Outlier Detection, where Local Outlier Factor (LOF) analysis with adaptive neighborhood selection identifies anomalous channels based on spectro-temporal features of chirp (Onset frequency, offset frequency, and temporal duration); and (2) Spatial Correlation Analysis, which computes both exact co-occurrence metrics and weighted index similarity, incorporating hemispheric congruence and electrode proximity. Key findings demonstrate that the LOF-based approach (N neighbors=20, contamination=0.2) effectively detects outliers, with index matching (weighted by channel proximity) outperforming exact matching in SOZ localization. Performance metrics (precision, recall, F1) were highest for seizure-free patients (Index Precision mean: 0.903) and those with successful surgical outcomes (Index Precision mean: 0.865), whereas failure cases exhibited lower concordance (Index Precision mean: 0.460). The key takeaway is that chirp-based outlier detection, combined with weighted spatial metrics, provides a complementary method for SOZ localization, particularly in patients with successful surgical outcomes.

cs.LG↗

arXiv2025

Chirp Localization via Fine-Tuned Transformer Model: A Proof-of-Concept Study

Spectrograms are pivotal in time-frequency signal analysis, widely used in audio processing and computational neuroscience. Chirp-like patterns in electroencephalogram (EEG) spectrograms (marked by linear or exponential frequency sweep) are key biomarkers for seizure dynamics, but automated tools for their detection, localization, and feature extraction are lacking. This study bridges this gap by fine-tuning a Vision Transformer (ViT) model on synthetic spectrograms, augmented with Low-Rank Adaptation (LoRA) to boost adaptability. We generated 100000 synthetic spectrograms with chirp parameters, creating the first large-scale benchmark for chirp localization. These spectrograms mimic neural chirps using linear or exponential frequency sweep, Gaussian noise, and smoothing. A ViT model, adapted for regression, predicted chirp parameters. LoRA fine-tuned the attention layers, enabling efficient updates to the pre-trained backbone. Training used MSE loss and the AdamW optimizer, with a learning rate scheduler and early stopping to curb overfitting. Only three features were targeted: Chirp Start Time (Onset Time), Chirp Start Frequency (Onset Frequency), and Chirp End Frequency (Offset Frequency). Performance was evaluated via Pearson correlation between predicted and actual labels. Results showed strong alignment: 0.9841 correlation for chirp start time, with stable inference times (137 to 140s) and minimal bias in error distributions. This approach offers a tool for chirp analysis in EEG time-frequency representation, filling a critical methodological void.

eess.AS↗

arXiv2025

Agentic Medical Knowledge Graphs Enhance Medical Question Answering: Bridging the Gap Between LLMs and Evolving Medical Knowledge

Large Language Models (LLMs) have significantly advanced medical question-answering by leveraging extensive clinical data and medical literature. However, the rapid evolution of medical knowledge and the labor-intensive process of manually updating domain-specific resources pose challenges to the reliability of these systems. To address this, we introduce Agentic Medical Graph-RAG (AMG-RAG), a comprehensive framework that automates the construction and continuous updating of medical knowledge graphs, integrates reasoning, and retrieves current external evidence, such as PubMed and WikiSearch. By dynamically linking new findings and complex medical concepts, AMG-RAG not only improves accuracy but also enhances interpretability in medical queries. Evaluations on the MEDQA and MEDMCQA benchmarks demonstrate the effectiveness of AMG-RAG, achieving an F1 score of 74.1 percent on MEDQA and an accuracy of 66.34 percent on MEDMCQA, outperforming both comparable models and those 10 to 100 times larger. Notably, these improvements are achieved without increasing computational overhead, highlighting the critical role of automated knowledge graph generation and external evidence retrieval in delivering up-to-date, trustworthy medical insights.

cs.CL↗

arXiv2024

Stochastic Sparse Sampling: A Framework for Variable-Length Medical Time Series Classification

While the majority of time series classification research has focused on modeling fixed-length sequences, variable-length time series classification (VTSC) remains critical in healthcare, where sequence length may vary among patients and events. To address this challenge, we propose $\textbf{S}$tochastic $\textbf{S}$parse $\textbf{S}$ampling (SSS), a novel VTSC framework developed for medical time series. SSS manages variable-length sequences by sparsely sampling fixed windows to compute local predictions, which are then aggregated and calibrated to form a global prediction. We apply SSS to the task of seizure onset zone (SOZ) localization, a critical VTSC problem requiring identification of seizure-inducing brain regions from variable-length electrophysiological time series. We evaluate our method on the Epilepsy iEEG Multicenter Dataset, a heterogeneous collection of intracranial electroencephalography (iEEG) recordings obtained from four independent medical centers. SSS demonstrates superior performance compared to state-of-the-art (SOTA) baselines across most medical centers, and superior performance on all out-of-distribution (OOD) unseen medical centers. Additionally, SSS naturally provides post-hoc insights into local signal characteristics related to the SOZ, by visualizing temporally averaged local predictions throughout the signal.

cs.LG↗

arXiv2024

Implicit Dynamical Flow Fusion (IDFF) for Generative Modeling

Conditional Flow Matching (CFM) models can generate high-quality samples from a non-informative prior, but they can be slow, often needing hundreds of network evaluations (NFE). To address this, we propose Implicit Dynamical Flow Fusion (IDFF); IDFF learns a new vector field with an additional momentum term that enables taking longer steps during sample generation while maintaining the fidelity of the generated distribution. Consequently, IDFFs reduce the NFEs by a factor of ten (relative to CFMs) without sacrificing sample quality, enabling rapid sampling and efficient handling of image and time-series data generation tasks. We evaluate IDFF on standard benchmarks such as CIFAR-10 and CelebA for image generation, where we achieve likelihood and quality performance comparable to CFMs and diffusion-based models with fewer NFEs. IDFF also shows superior performance on time-series datasets modeling, including molecular simulation and sea surface temperature (SST) datasets, highlighting its versatility and effectiveness across different domains.\href{https://github.com/MrRezaeiUofT/IDFF}{Github Repository}

cs.LG↗

arXiv2023

Deep Direct Discriminative Decoders for High-dimensional Time-series Data Analysis

The state-space models (SSMs) are widely utilized in the analysis of time-series data. SSMs rely on an explicit definition of the state and observation processes. Characterizing these processes is not always easy and becomes a modeling challenge when the dimension of observed data grows or the observed data distribution deviates from the normal distribution. Here, we propose a new formulation of SSM for high-dimensional observation processes. We call this solution the deep direct discriminative decoder (D4). The D4 brings deep neural networks' expressiveness and scalability to the SSM formulation letting us build a novel solution that efficiently estimates the underlying state processes through high-dimensional observation signal. We demonstrate the D4 solutions in simulated and real data such as Lorenz attractors, Langevin dynamics, random walk dynamics, and rat hippocampus spiking neural data and show that the D4 performs better than traditional SSMs and RNNs. The D4 can be applied to a broader class of time-series data where the connection between high-dimensional observation and the underlying latent process is hard to characterize.

cs.LG↗

arXiv2022

Uncovering the Origins of Instability in Dynamical Systems: How Attention Mechanism Can Help?

The behavior of the network and its stability are governed by both dynamics of individual nodes as well as their topological interconnections. Attention mechanism as an integral part of neural network models was initially designed for natural language processing (NLP), and so far, has shown excellent performance in combining dynamics of individual nodes and the coupling strengths between them within a network. Despite undoubted impact of attention mechanism, it is not yet clear why some nodes of a network get higher attention weights. To come up with more explainable solutions, we tried to look at the problem from stability perspective. Based on stability theory, negative connections in a network can create feedback loops or other complex structures by allowing information to flow in the opposite direction. These structures play a critical role in the dynamics of a complex system and can contribute to abnormal synchronization, amplification, or suppression. We hypothesized that those nodes that are involved in organizing such structures can push the entire network into instability modes and therefore need higher attention during analysis. To test this hypothesis, attention mechanism along with spectral and topological stability analyses was performed on a real-world numerical problem, i.e., a linear Multi Input Multi Output state-space model of a piezoelectric tube actuator. The findings of our study suggest that the attention should be directed toward the collective behaviour of imbalanced structures and polarity-driven structural instabilities within the network. The results demonstrated that the nodes receiving more attention cause more instability in the system. Our study provides a proof of concept to understand why perturbing some nodes of a network may cause dramatic changes in the network dynamics.

cs.LG↗

arXiv2021

Gradient-Free Neural Network Training via Synaptic-Level Reinforcement Learning

An ongoing challenge in neural information processing is: how do neurons adjust their connectivity to improve task performance over time (i.e., actualize learning)? It is widely believed that there is a consistent, synaptic-level learning mechanism in specific brain regions that actualizes learning. However, the exact nature of this mechanism remains unclear. Here we propose an algorithm based on reinforcement learning (RL) to generate and apply a simple synaptic-level learning policy for multi-layer perceptron (MLP) models. In this algorithm, the action space for each MLP synapse consists of a small increase, decrease, or null action on the synapse weight, and the state for each synapse consists of the last two actions and reward signals. A binary reward signal indicates improvement or deterioration in task performance. The static policy produces superior training relative to the adaptive policy and is agnostic to activation function, network shape, and task. Trained MLPs yield character recognition performance comparable to identically shaped networks trained with gradient descent. 0 hidden unit character recognition tests yielded an average validation accuracy of 88.28%, 1.86$\pm$0.47% higher than the same MLP trained with gradient descent. 32 hidden unit character recognition tests yielded an average validation accuracy of 88.45%, 1.11$\pm$0.79% lower than the same MLP trained with gradient descent. The robustness and lack of reliance on gradient computations opens the door for new techniques for training difficult-to-differentiate artificial neural networks such as spiking neural networks (SNNs) and recurrent neural networks (RNNs). Further, the method's simplicity provides a unique opportunity for further development of local rule-driven multi-agent connectionist models for machine intelligence analogous to cellular automata.

cs.NE↗