arXiv subjects

Milan Gautam

Publications and source records attributed to Milan Gautam.

3 recordsLinked to original sources

arXiv2026

Direct Translation between Sign Languages

The field of sign language translation has witnessed significant progress in the translation between sign and spoken languages, but the translation between sign languages remains largely unexplored and out of reach. The latter can help 1.5 billion deaf and hard-of-hearing (DHH) people worldwide communicate across language barriers without relying on hearing interpreters or written-language fluency. The cascade approach composing separate sign-to-text, text-to-text, and text-to-sign systems suffers from error propagation and extra latency as well as the loss of information unique in the visual modality. We aim to develop direct sign-to-sign translation. However, a large-scale open-domain parallel corpus has not been curated between sign languages. To enable direct translation between sign language utterances, we use back-translation to produce synthetic sign-sign pairs from unaligned individual language utterance-sign corpora. Using this data, we jointly train a single MBART-based model for both text->sign (T2S) and sign->sign (S2S). On synthetically generated paired sets between American Sign Language (ASL), Chinese Sign Language (CSL), and German Sign Language (DGS), our direct S2S method outperforms the cascaded baseline on geometric sign error metrics (20% lower DTW-aligned MPJPE) and language matching metrics after predicted sign utterances are translated back to sentences (50% high BLEU-4) while achieving a roughly 2.3* speedup. On a small set of pre-existing cross-lingual sign data, we find similar improvements for our proposed method.

cs.CL↗

arXiv2026

Designing RNAs with Language Models

RNA design, the task of finding a sequence that folds into a target secondary structure, has broad biological and biomedical impact but remains computationally challenging due to the exponentially large sequence space and exponentially many competing folds. Traditional approaches treat it as an optimization problem, relying on per-instance heuristics or constraint-based search. We instead reframe RNA design as conditional sequence generation and introduce a reusable neural approximator, instantiated as an autoregressive language model (LM), that maps target structures directly to sequences. We first train our model in a supervised setting on random-induced structure-sequence pairs, and then use reinforcement learning (RL) to optimize end-to-end metrics. We also propose methods to select a small subset for RL that greatly improves RL efficiency and quality. Across four datasets, our approach outperforms state-of-the-art systems on key metrics such as Boltzmann probability while being 1.7x faster, establishing conditional LM generation as a scalable, task-agnostic alternative to per-instance optimization for RNA design. Our code and data are available at https://github.com/KuNyaa/RNA-Design-LM.

cs.LG↗

arXiv2024

LinearAlifold: Linear-Time Consensus Structure Prediction for RNA Alignments

Predicting the consensus structure of a set of aligned RNA homologs is a convenient method to find conserved structures in an RNA genome, which has many applications including viral diagnostics and therapeutics. However, the most commonly used tool for this task, RNAalifold, is prohibitively slow for long sequences, due to a cubic scaling with the sequence length, taking over a day on 400 SARS-CoV-2 and SARS-related genomes (~30,000nt). We present LinearAlifold, a much faster alternative that scales linearly with both the sequence length and the number of sequences, based on our work LinearFold that folds a single RNA in linear time. Our work is orders of magnitude faster than RNAalifold (0.7 hours on the above 400 genomes, or ~36$\times$ speedup) and achieves higher accuracies when compared to a database of known structures. More interestingly, LinearAlifold's prediction on SARS-CoV-2 correlates well with experimentally determined structures, substantially outperforming RNAalifold. Finally, LinearAlifold supports two energy models (Vienna and BL*) and four modes: minimum free energy (MFE), maximum expected accuracy (MEA), ThreshKnot, and stochastic sampling, each of which takes under an hour for hundreds of SARS-CoV variants. Our resource is at: https://github.com/LinearFold/LinearAlifold (code) and http://linearfold.org/linear-alifold (server).

q-bio.BM↗