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Min Yao

Publications and source records attributed to Min Yao.

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Children's English Reading Story Generation via Supervised Fine-Tuning of Compact LLMs with Controllable Difficulty and Safety

Large Language Models (LLMs) are widely applied in educational practices, such as for generating children's stories. However, the generated stories are often too difficult for children to read, and the operational cost of LLMs hinders their widespread adoption in educational settings. We used an existing expert-designed children's reading curriculum and its corresponding generated stories from GPT-4o and Llama 3.3 70B to design different experiments for fine-tuning three 8B-parameter LLMs, which then generated new English reading stories that were subjected to quantitative and qualitative evaluation. Our method prioritizes controllability over scale, enabling educators to target reading levels and error patterns with a compact, affordable model. Our evaluation results show that with appropriate fine-tuning designs, children's English reading stories generated by 8B LLMs perform better on difficulty-related metrics than those from zero-shot GPT-4o and Llama 3.3 70B, with almost no discernible safety issues. Such fine-tuned LLMs could be more broadly used by teachers, parents, and children in classrooms and at home to generate engaging English reading stories with children's interests, controllable difficulty and safety.

cs.CL

Language model driven: a PROTAC generation pipeline with dual constraints of structure and property

The imperfect modeling of ternary complexes has limited the application of computer-aided drug discovery tools in PROTAC research and development. In this study, an AI-assisted approach for PROTAC molecule design pipeline named LM-PROTAC was developed, which stands for language model driven Proteolysis Targeting Chimera, by embedding a transformer-based generative model with dual constraints on structure and properties, referred to as the DCT. This study utilized the fragmentation representation of molecules and developed a language model driven pipeline. Firstly, a language model driven affinity model for protein compounds to screen molecular fragments with high affinity for the target protein. Secondly, structural and physicochemical properties of these fragments were constrained during the generation process to meet specific scenario requirements. Finally, a two-round screening of the preliminary generated molecules using a multidimensional property prediction model to generate a batch of PROTAC molecules capable of degrading disease-relevant target proteins for validation in vitro experiments, thus achieving a complete solution for AI-assisted PROTAC drug generation. Taking the tumor key target Wnt3a as an example, the LM-PROTAC pipeline successfully generated PROTAC molecules capable of inhibiting Wnt3a. The results show that DCT can efficiently generate PROTAC that targets and hydrolyses Wnt3a.

q-bio.QM

Multi-Depth Branch Network for Efficient Image Super-Resolution

A longstanding challenge in Super-Resolution (SR) is how to efficiently enhance high-frequency details in Low-Resolution (LR) images while maintaining semantic coherence. This is particularly crucial in practical applications where SR models are often deployed on low-power devices. To address this issue, we propose an innovative asymmetric SR architecture featuring Multi-Depth Branch Module (MDBM). These MDBMs contain branches of different depths, designed to capture high- and low-frequency information simultaneously and efficiently. The hierarchical structure of MDBM allows the deeper branch to gradually accumulate fine-grained local details under the contextual guidance of the shallower branch. We visualize this process using feature maps, and further demonstrate the rationality and effectiveness of this design using proposed novel Fourier spectral analysis methods. Moreover, our model exhibits more significant spectral differentiation between branches than existing branch networks. This suggests that MDBM reduces feature redundancy and offers a more effective method for integrating high- and low-frequency information. Extensive qualitative and quantitative evaluations on various datasets show that our model can generate structurally consistent and visually realistic HR images. It achieves state-of-the-art (SOTA) results at a very fast inference speed. Our code is available at https://github.com/thy960112/MDBN.

eess.IV

Correlation between the ionizing continuum and variable C iv broad absorption line in multi-epoch observations of SDSS J141007.74+541203.3

Correlation between the variations of quasar absorption lines and the ionizing continuum have been recently confirmed in systematic studies. However, no convincing individual case is reported. We present a statistical analysis of the variable C iv broad absorption line (BAL) in the quasar SDSS J141007.74+541203.3, which have been observed with 44 epochs by the Sloan Digital Sky Survey Data Release 14. Grier et al. (2015) has recently concluded that the most likely cause of the variability of the BAL in SDSS J141007.74+541203.3 is a rapid response to changes in the incident ionizing continuum. In this paper, we confirm the anticorrelation between the equivalent width of BALs and the flux of the continuum based on the spectra of this quasar that show significant variations, which serve as another independent evidence for the view of Grier et al. (2015).

astro-ph.GA

Evidence for photoionization-driven variability in narrow absorption lines

In this Letter, we report the discovery of a strong correlation between the variability of narrow absorption lines (NALs) and the ionizing continuum from a two-epoch spectra sample of 40 quasars containing 52 variable C iv λλ1548; 1551 absorption doublets. According to the concordance index, this sample is classified into two subsamples. Subsample I shows an anti-correlation between the variations of absorption lines and the continuum, while Subsample II exhibits a positive correlation. These results imply that these variable C iv λλ1548; 1551 absorption doublets are intrinsic to the corresponding quasars and that their variations are caused primarily by the fluctuations of the ionizing continuum. Based on our analysis, we propose that there might be two kinds of absorption gas: one that is very sensitive to the continuum variations, the another that is not. In addition, we suggest that in many cases the emergence or disappearance of NALs is caused by fluctuations of the ionizing continuum.

astro-ph.GA

The Gravitational Deflection of Light in F(R)-gravity

The fact that the gravitation could deflect the light trajectory has been confirmed by a large number of observation data, that is consistent with the result calculated by Einstein's gravity. F(R)-gravity is the modification of Einstein's gravity. According to the field equations obtained by the action of the f(R) form, we get a similar Schwarzschild metric. According to the condition that four-dimension momenta of the photon return to zero and that of conservation of covariant momenta, we obtain the equation of motion of the photon in a specific form of f (R)-gravity. We solve the equation to get the gravitational deflection angle of light that grazes the surface of sun and the calculation result is consistent with the experimental observation data.

gr-qc