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Ming-Chun Hong

Publications and source records attributed to Ming-Chun Hong.

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Solving Boolean Satisfiability Problems Using A Hypergraph-based Probabilistic Computer

Boolean Satisfiability (SAT) problems are critical in fields such as artificial intelligence and cryptography, where efficient solutions are essential. Conventional probabilistic solvers often encounter scalability issues due to complex logic synthesis steps. In this work, we present a novel approach for solving the 3-SAT Boolean satisfiability problem using hypergraph-based probabilistic computers obtained through direct mapping. This method directly translates 3-SAT logical expressions into hypergraph structures, thereby circumventing conventional logic decomposition and synthesis procedures, and offering a more streamlined solver architecture. For representative uf100-430 instances, the proposed approach reduces the node count from 631 to 100 and the edge count from ~2,423 to ~1,013. Under identical simulated annealing conditions, the conventional simple undirected graph (SUG)-based solver achieves a 0% success rate across the tested instances, whereas the hypergraph-based solver attains an average success rate of ~77.6%. In addition, the hypergraph-based method reaches an average minimum energy of ~0.24, close to the theoretical ground state, while the SUG-based architecture remains trapped at substantially higher energy levels (~9.12 on average). The direct hypergraph mapping can further be extended to k-SAT formulations, providing a scalable framework for more complex satisfiability problems in probabilistic computing.

physics.comp-ph

The First Hardware Demonstration of a Universal Programmable RRAM-based Probabilistic Computer for Molecular Docking

Molecular docking is a critical computational strategy in drug design and discovery, but the complex diversity of biomolecular structures and flexible binding conformations create an enormous search space that challenges conventional computing methods. Although quantum computing holds promise for these challenges, it remains constrained by scalability, hardware limitations, and precision issues. Here, we report a prototype of a probabilistic computer (p-computer) that efficiently and accurately solves complex molecular docking for the first time, overcoming previously encountered challenges. At the core of the system is a p-computing chip based upon our artificial tunable probabilistic bits (p-bits), which are compatible with computing-in-memory schemes, based upon 180 nm CMOS technology and BEOL HfO2 RRAM. We successfully demonstrated the superior performance of the p-computer in practical ligand-protein docking scenarios. A 42-node molecular docking problem of lipoprotein with LolA-LolCDE complex-a key point in developing antibiotics against Gram-negative bacteria, was successfully solved. Our results align well with the Protein-Ligand Interaction Profiler tool. This work marks the first application of p-computing in molecular docking-based computational biology, which has great potential to overcome the limitations in success rate and efficiency of current technologies in addressing complex bioinformatics problems.

physics.comp-ph