arXiv subjects

Mingda Xu

Publications and source records attributed to Mingda Xu.

6 recordsLinked to original sources

arXiv2026

GenMed: A Pairwise Generative Reformulation of Medical Diagnostic Tasks

Data-driven medical AI is traditionally formulated as a discriminative mapping from input $X$ to output $Y$ via a learned function $f$, which does not generalize well across heterogeneous data and modalities encountered in real-world clinical settings. In this work, we propose a fundamentally different, generative paradigm. We model the joint distribution $P(X,Y)$ using diffusion models and reframe inference as a test-time output optimization problem. By guiding the generative process to match observed inputs, our framework enables flexible, gradient-based conditioning at inference time without architectural changes or retraining, effectively supporting arbitrary and previously unseen combinations of observations. Extensive experiments demonstrate strong performance across standard and cross-modality medical image segmentation, few-shot segmentation with only 2 or 4 training samples, degraded-input segmentation, shape completion from sparse and partial observations, and zero-shot application to demonstrate generality. To support these evaluations, we curated and released a large-scale text-shape dataset derived from MedShapeNet. Our results highlight the versatility of generative joint modeling as a foundation for reusable, task-agnostic medical AI systems.

cs.CV↗

arXiv2026

Anchored Cyclic Generation: A Novel Paradigm for Long-Sequence Symbolic Music Generation

Generating long sequences with structural coherence remains a fundamental challenge for autoregressive models across sequential generation tasks. In symbolic music generation, this challenge is particularly pronounced, as existing methods are constrained by the inherent severe error accumulation problem of autoregressive models, leading to poor performance in music quality and structural integrity. In this paper, we propose the Anchored Cyclic Generation (ACG) paradigm, which relies on anchor features from already identified music to guide subsequent generation during the autoregressive process, effectively mitigating error accumulation in autoregressive methods. Based on the ACG paradigm, we further propose the Hierarchical Anchored Cyclic Generation (Hi-ACG) framework, which employs a systematic global-to-local generation strategy and is highly compatible with our specifically designed piano token, an efficient musical representation. The experimental results demonstrate that compared to traditional autoregressive models, the ACG paradigm achieves reduces cosine distance by an average of 34.7% between predicted feature vectors and ground-truth semantic vectors. In long-sequence symbolic music generation tasks, the Hi-ACG framework significantly outperforms existing mainstream methods in both subjective and objective evaluations. Furthermore, the framework exhibits excellent task generalization capabilities, achieving superior performance in related tasks such as music completion.

cs.SD↗

arXiv2026

Gradient-based Nested Co-Design of Aerodynamic Shape and Control for Winged Robots

Designing aerial robots for specialized tasks, from perching to payload delivery, requires tailoring their aerodynamic shape to specific mission requirements. For tasks involving wide flight envelopes, the usual sequential process of first determining the shape and then the motion planner is likely to be suboptimal due to the inherent nonlinear interactions between them. This limitation has been motivating co-design research, which involves jointly optimizing the aerodynamic shape and the motion planner. In this paper, we present a general-purpose, gradient-based, nested co-design framework where the motion planner solves an optimal control problem and the aerodynamic forces used in the dynamics model are determined by a neural surrogate model. This enables us to model complex subsonic flow conditions encountered in aerial robotics and to overcome the limited applicability of existing co-design methods. These limitations stem from the simplifying assumptions they require for computational tractability to either the planner or the aerodynamics. We validate our method on two complex dynamic tasks for fixed-wing gliders: perching and a short landing. Our optimized designs improve task performance compared to an evolutionary baseline in a fraction of the computation time.

cs.RO↗

arXiv2026

Annealed Co-Generation: Disentangling Variables via Progressive Pairwise Modeling

For multivariate co-generation in scientific applications, we advocate pairwise block rather than joint modeling of all variables. This design mitigates the computational burden and data imbalance. To this end, we propose an Annealed Co-Generation (ACG) framework that replaces high-dimensional diffusion modeling with a low-dimensional diffusion model, which enables multivariate co-generation by composing pairwise variable generations. We first train an unconditional diffusion model over causal variables that are disentangled into pairs. At inference time, we recover the joint distribution by coupling these pairwise models through shared common variables, enabling coherent multivariate generation without any additional training. By employing a three-stage annealing process-Consensus, Heating, and Cooling-our method enforces consistency across shared common variables and progressively constrains each pairwise data distribution to lie on a learnable manifold, while maintaining high likelihood within each pair. We demonstrate the framework's flexibility and efficacy on two distinct scientific tasks: flow-field completion and antibody generation. All datasets and code will be made publicly available upon publication.

cs.LG↗

arXiv2025

TraGraph-GS: Trajectory Graph-based Gaussian Splatting for Arbitrary Large-Scale Scene Rendering

High-quality novel view synthesis for large-scale scenes presents a challenging dilemma in 3D computer vision. Existing methods typically partition large scenes into multiple regions, reconstruct a 3D representation using Gaussian splatting for each region, and eventually merge them for novel view rendering. They can accurately render specific scenes, yet they do not generalize effectively for two reasons: (1) rigid spatial partition techniques struggle with arbitrary camera trajectories, and (2) the merging of regions results in Gaussian overlap to distort texture details. To address these challenges, we propose TraGraph-GS, leveraging a trajectory graph to enable high-precision rendering for arbitrarily large-scale scenes. We present a spatial partitioning method for large-scale scenes based on graphs, which incorporates a regularization constraint to enhance the rendering of textures and distant objects, as well as a progressive rendering strategy to mitigate artifacts caused by Gaussian overlap. Experimental results demonstrate its superior performance both on four aerial and four ground datasets and highlight its remarkable efficiency: our method achieves an average improvement of 1.86 dB in PSNR on aerial datasets and 1.62 dB on ground datasets compared to state-of-the-art approaches.

cs.CV↗

arXiv2024

Graph Neural Networks for Protein-Protein Interactions -- A Short Survey

Protein-protein interactions (PPIs) play key roles in a broad range of biological processes. Numerous strategies have been proposed for predicting PPIs, and among them, graph-based methods have demonstrated promising outcomes owing to the inherent graph structure of PPI networks. This paper reviews various graph-based methodologies, and discusses their applications in PPI prediction. We classify these approaches into two primary groups based on their model structures. The first category employs Graph Neural Networks (GNN) or Graph Convolutional Networks (GCN), while the second category utilizes Graph Attention Networks (GAT), Graph Auto-Encoders and Graph-BERT. We highlight the distinctive methodologies of each approach in managing the graph-structured data inherent in PPI networks and anticipate future research directions in this domain.

cs.LG↗