arXiv subjects

Mingxin Liu

Publications and source records attributed to Mingxin Liu.

15 recordsLinked to original sources

arXiv2026

Synergistic Information Disentanglement for Omni-modal Slide Representation Learning in Computational Pathology

In computational pathology (CPath), developing omni-modal self-supervised learning (SSL) models that integrate histology, genomics, and clinical reports enables transferable representation learning for whole slide images (WSIs). Existing approaches implicitly force heterogeneous modalities into a uniform latent space by contrastive alignment, causing modality collapse where unique, synergistic diagnostic signals (termed as $\mathrm{\Phi}$) are discarded in favor of trivial redundancy. We hypothesize that the strongest task-agnostic SSL training signal stems from distilling the synergistic interactions over merely aligning shared redundancy. To this end, we introduce \textsc{$\mathrm{\Phi}$-Omni}, a synergistic information disentanglement framework grounded in Partial Information Decomposition (PID) theory for slide representation learning. Unlike standard contrastive approaches, \textsc{$\mathrm{\Phi}$-Omni} employs a Synergistic Information Bottleneck (SIB) regulated by the proposed $\mathrm{\Phi}\text{ID}$ objective, which explicitly suppresses marginal redundancy while maximizing irreducible synergy, thereby distilling high-order cross-modal interactions. Following pretraining on breast ($n$=1031) and lung ($n$=919) cohorts, \textsc{$\mathrm{\Phi}$-Omni} demonstrates superior few-shot performance across five independent external datasets spanning eight tasks compared to supervised and SSL baselines. Source code is available here.

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arXiv2026

FIRM-Video: Check Before You Score for Reliable Text-to-Video Reward Modeling

Reliable reward models are essential for text-to-video evaluation and alignment. However, the trade-off between evaluation accuracy and inference efficiency places high demands on the quality of training supervision. Existing approaches often rely on holistic judges with fixed rubrics or open-ended reasoning, leading to incomplete inspection, unfaithful justification, and entangled attribution. We introduce FIRM-Video, a unified checklist-driven data construction framework based on a check-before-score principle: construct dimension-specific checklists, verify each criterion against temporal visual evidence, and aggregate only verified decisions. For Instruction Following, FIRM-Video decomposes prompts into weighted atomic requirements; for World Coherence, it constructs prompt-calibrated, target-specific checks grounded in visible entities and actions; and for Perceptual Quality, it applies a generic taxonomy of visual defects. The verified criteria and scores are further transformed into natural-language analyses for end-to-end reward modeling. Subsequently, we construct FIRM-Video-90K with 88,044 dimension-specific instances from 29,348 videos, and introduce FIRM-Video-Bench with 750 point-wise human annotations across 250 videos. The Qwen3-VL-based FIRM-Video-8B achieves the best overall MAE on FIRM-Video-Bench while consistently delivering the highest VBench Total, Quality, and Semantic Scores in Best-of-8 sampling across three video generators.

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arXiv2026

DisciplineGen-1M: A Large-Scale Dataset for Multidisciplinary Visual Generation and Editing

Recent image generation and editing models can produce visually appealing natural images, yet they remain unreliable when the target image is a knowledge-intensive diagram whose correctness depends on disciplinary concepts, symbolic structure, and precise spatial relations. We introduce DisciplineGen-1M, a million-scale multidisciplinary dataset that supports text-to-image generation and image editing. It contains 1.2M samples spanning mathematics, physics, chemistry, biology, geography, computer science, economics, history, music, and sports. To construct the dataset, we design a scalable framework that combines structured rendering, OCR-based editing, specialized programmatic synthesis, and large-scale text-to-image filtering. These pipelines produce captions, editing instructions, structured annotations, and paired images with controllable semantic differences. Building on DisciplineGen-1M, we further introduce a discipline-informed reasoning-generation model for both text-to-image generation and image editing. Experiments on discipline-related benchmarks, GenExam and GRADE, show substantial improvements over open-source baselines, while evaluations on general reasoning-informed benchmarks, WISE and RISE, further indicate broader transfer. The results suggest that large-scale structured academic visual data is a key ingredient for moving image generation from aesthetic plausibility toward verifiable knowledge-grounded visual creation. We will publicly release our dataset, model, and source code of the data curation pipeline to ensure reproducibility and benefit future research.

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arXiv2026

GRADE: Benchmarking Discipline-Informed Reasoning in Image Editing

Unified multimodal models target joint understanding, reasoning, and generation, but current image editing benchmarks are largely confined to natural images and shallow commonsense reasoning, offering limited assessment of this capability under structured, domain-specific constraints. In this work, we introduce GRADE, the first benchmark to assess discipline-informed knowledge and reasoning in image editing. GRADE comprises 520 carefully curated samples across 10 academic domains, spanning from natural science to social science. To support rigorous evaluation, we propose a multi-dimensional evaluation protocol that jointly assesses Discipline Reasoning, Visual Consistency, and Logical Readability. Extensive experiments on 20 state-of-the-art open-source and closed-source models reveal substantial limitations in current models under implicit, knowledge-intensive editing settings, leading to large performance gaps. Beyond quantitative scores, we conduct rigorous analyses and ablations to expose model shortcomings and identify the constraints within disciplinary editing. Together, GRADE pinpoints key directions for the future development of unified multimodal models, advancing the research on discipline-informed image editing and reasoning. Our benchmark and evaluation code are publicly released.

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arXiv2026

InternVL-U: Democratizing Unified Multimodal Models for Understanding, Reasoning, Generation and Editing

Unified multimodal models (UMMs) that integrate understanding, reasoning, generation, and editing face inherent trade-offs between maintaining strong semantic comprehension and acquiring powerful generation capabilities. In this report, we present InternVL-U, a lightweight 4B-parameter UMM that democratizes these capabilities within a unified framework. Guided by the principles of unified contextual modeling and modality-specific modular design with decoupled visual representations, InternVL-U integrates a state-of-the-art Multimodal Large Language Model (MLLM) with a specialized MMDiT-based visual generation head. To further bridge the gap between aesthetic generation and high-level intelligence, we construct a comprehensive data synthesis pipeline targeting high-semantic-density tasks, such as text rendering and scientific reasoning, under a reasoning-centric paradigm that leverages Chain-of-Thought (CoT) to better align abstract user intent with fine-grained visual generation details. Extensive experiments demonstrate that InternVL-U achieves a superior performance - efficiency balance. Despite using only 4B parameters, it consistently outperforms unified baseline models with over 3x larger scales such as BAGEL (14B) on various generation and editing tasks, while retaining strong multimodal understanding and reasoning capabilities.

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arXiv2026

RISE-Video: Can Video Generators Decode Implicit World Rules?

While generative video models have achieved remarkable visual fidelity, their capacity to internalize and reason over implicit world rules remains a critical yet under-explored frontier. To bridge this gap, we present RISE-Video, a pioneering reasoning-oriented benchmark for Text-Image-to-Video (TI2V) synthesis that shifts the evaluative focus from surface-level aesthetics to deep cognitive reasoning. RISE-Video comprises 467 meticulously human-annotated samples spanning eight rigorous categories, providing a structured testbed for probing model intelligence across diverse dimensions, ranging from commonsense and spatial dynamics to specialized subject domains. Our framework introduces a multi-dimensional evaluation protocol consisting of four metrics: \textit{Reasoning Alignment}, \textit{Temporal Consistency}, \textit{Physical Rationality}, and \textit{Visual Quality}. To further support scalable evaluation, we propose an automated pipeline leveraging Large Multimodal Models (LMMs) to emulate human-centric assessment. Extensive experiments on 11 state-of-the-art TI2V models reveal pervasive deficiencies in simulating complex scenarios under implicit constraints, offering critical insights for the advancement of future world-simulating generative models.

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arXiv2026

SPWOOD: Sparse Partial Weakly-Supervised Oriented Object Detection

A consistent trend throughout the research of oriented object detection has been the pursuit of maintaining comparable performance with fewer and weaker annotations. This is particularly crucial in the remote sensing domain, where the dense object distribution and a wide variety of categories contribute to prohibitively high costs. Based on the supervision level, existing oriented object detection algorithms can be broadly grouped into fully supervised, semi-supervised, and weakly supervised methods. Within the scope of this work, we further categorize them to include sparsely supervised and partially weakly-supervised methods. To address the challenges of large-scale labeling, we introduce the first Sparse Partial Weakly-Supervised Oriented Object Detection framework, designed to efficiently leverage only a few sparse weakly-labeled data and plenty of unlabeled data. Our framework incorporates three key innovations: (1) We design a Sparse-annotation-Orientation-and-Scale-aware Student (SOS-Student) model to separate unlabeled objects from the background in a sparsely-labeled setting, and learn orientation and scale information from orientation-agnostic or scale-agnostic weak annotations. (2) We construct a novel Multi-level Pseudo-label Filtering strategy that leverages the distribution of model predictions, which is informed by the model's multi-layer predictions. (3) We propose a unique sparse partitioning approach, ensuring equal treatment for each category. Extensive experiments on the DOTA and DIOR datasets show that our framework achieves a significant performance gain over traditional oriented object detection methods mentioned above, offering a highly cost-effective solution. Our code is publicly available at https://github.com/VisionXLab/SPWOOD.

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arXiv2025

A Hierarchical Geometry-guided Transformer for Histological Subtyping of Primary Liver Cancer

Primary liver malignancies are widely recognized as the most heterogeneous and prognostically diverse cancers of the digestive system. Among these, hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) emerge as the two principal histological subtypes, demonstrating significantly greater complexity in tissue morphology and cellular architecture than other common tumors. The intricate representation of features in Whole Slide Images (WSIs) encompasses abundant crucial information for liver cancer histological subtyping, regarding hierarchical pyramid structure, tumor microenvironment (TME), and geometric representation. However, recent approaches have not adequately exploited these indispensable effective descriptors, resulting in a limited understanding of histological representation and suboptimal subtyping performance. To mitigate these limitations, ARGUS is proposed to advance histological subtyping in liver cancer by capturing the macro-meso-micro hierarchical information within the TME. Specifically, we first construct a micro-geometry feature to represent fine-grained cell-level pattern via a geometric structure across nuclei, thereby providing a more refined and precise perspective for delineating pathological images. Then, a Hierarchical Field-of-Views (FoVs) Alignment module is designed to model macro- and meso-level hierarchical interactions inherent in WSIs. Finally, the augmented micro-geometry and FoVs features are fused into a joint representation via present Geometry Prior Guided Fusion strategy for modeling holistic phenotype interactions. Extensive experiments on public and private cohorts demonstrate that our ARGUS achieves state-of-the-art (SOTA) performance in histological subtyping of liver cancer, which provide an effective diagnostic tool for primary liver malignancies in clinical practice.

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arXiv2025

Point2RBox-v3: Self-Bootstrapping from Point Annotations via Integrated Pseudo-Label Refinement and Utilization

Driven by the growing need for Oriented Object Detection (OOD), learning from point annotations under a weakly-supervised framework has emerged as a promising alternative to costly and laborious manual labeling. In this paper, we discuss two deficiencies in existing point-supervised methods: inefficient utilization and poor quality of pseudo labels. Therefore, we present Point2RBox-v3. At the core are two principles: 1) Progressive Label Assignment (PLA). It dynamically estimates instance sizes in a coarse yet intelligent manner at different stages of the training process, enabling the use of label assignment methods. 2) Prior-Guided Dynamic Mask Loss (PGDM-Loss). It is an enhancement of the Voronoi Watershed Loss from Point2RBox-v2, which overcomes the shortcomings of Watershed in its poor performance in sparse scenes and SAM's poor performance in dense scenes. To our knowledge, Point2RBox-v3 is the first model to employ dynamic pseudo labels for label assignment, and it creatively complements the advantages of SAM model with the watershed algorithm, which achieves excellent performance in both sparse and dense scenes. Our solution gives competitive performance, especially in scenarios with large variations in object size or sparse object occurrences: 66.09%/56.86%/41.28%/46.40%/19.60%/45.96% on DOTA-v1.0/DOTA-v1.5/DOTA-v2.0/DIOR/STAR/RSAR.

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arXiv2025

MurreNet: Modeling Holistic Multimodal Interactions Between Histopathology and Genomic Profiles for Survival Prediction

Cancer survival prediction requires integrating pathological Whole Slide Images (WSIs) and genomic profiles, a challenging task due to the inherent heterogeneity and the complexity of modeling both inter- and intra-modality interactions. Current methods often employ straightforward fusion strategies for multimodal feature integration, failing to comprehensively capture modality-specific and modality-common interactions, resulting in a limited understanding of multimodal correlations and suboptimal predictive performance. To mitigate these limitations, this paper presents a Multimodal Representation Decoupling Network (MurreNet) to advance cancer survival analysis. Specifically, we first propose a Multimodal Representation Decomposition (MRD) module to explicitly decompose paired input data into modality-specific and modality-shared representations, thereby reducing redundancy between modalities. Furthermore, the disentangled representations are further refined then updated through a novel training regularization strategy that imposes constraints on distributional similarity, difference, and representativeness of modality features. Finally, the augmented multimodal features are integrated into a joint representation via proposed Deep Holistic Orthogonal Fusion (DHOF) strategy. Extensive experiments conducted on six TCGA cancer cohorts demonstrate that our MurreNet achieves state-of-the-art (SOTA) performance in survival prediction.

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arXiv2025

Partial Weakly-Supervised Oriented Object Detection

The growing demand for oriented object detection (OOD) across various domains has driven significant research in this area. However, the high cost of dataset annotation remains a major concern. Current mainstream OOD algorithms can be mainly categorized into three types: (1) fully supervised methods using complete oriented bounding box (OBB) annotations, (2) semi-supervised methods using partial OBB annotations, and (3) weakly supervised methods using weak annotations such as horizontal boxes or points. However, these algorithms inevitably increase the cost of models in terms of annotation speed or annotation cost. To address this issue, we propose: (1) the first Partial Weakly-Supervised Oriented Object Detection (PWOOD) framework based on partially weak annotations (horizontal boxes or single points), which can efficiently leverage large amounts of unlabeled data, significantly outperforming weakly supervised algorithms trained with partially weak annotations, also offers a lower cost solution; (2) Orientation-and-Scale-aware Student (OS-Student) model capable of learning orientation and scale information with only a small amount of orientation-agnostic or scale-agnostic weak annotations; and (3) Class-Agnostic Pseudo-Label Filtering strategy (CPF) to reduce the model's sensitivity to static filtering thresholds. Comprehensive experiments on DOTA-v1.0/v1.5/v2.0 and DIOR datasets demonstrate that our PWOOD framework performs comparably to, or even surpasses traditional semi-supervised algorithms. Our code will be made publicly available.

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arXiv2025

Point2RBox-v2: Rethinking Point-supervised Oriented Object Detection with Spatial Layout Among Instances

With the rapidly increasing demand for oriented object detection (OOD), recent research involving weakly-supervised detectors for learning OOD from point annotations has gained great attention. In this paper, we rethink this challenging task setting with the layout among instances and present Point2RBox-v2. At the core are three principles: 1) Gaussian overlap loss. It learns an upper bound for each instance by treating objects as 2D Gaussian distributions and minimizing their overlap. 2) Voronoi watershed loss. It learns a lower bound for each instance through watershed on Voronoi tessellation. 3) Consistency loss. It learns the size/rotation variation between two output sets with respect to an input image and its augmented view. Supplemented by a few devised techniques, e.g. edge loss and copy-paste, the detector is further enhanced. To our best knowledge, Point2RBox-v2 is the first approach to explore the spatial layout among instances for learning point-supervised OOD. Our solution is elegant and lightweight, yet it is expected to give a competitive performance especially in densely packed scenes: 62.61%/86.15%/34.71% on DOTA/HRSC/FAIR1M. Code is available at https://github.com/VisionXLab/point2rbox-v2.

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arXiv2024

Unleashing the Infinity Power of Geometry: A Novel Geometry-Aware Transformer (GOAT) for Whole Slide Histopathology Image Analysis

The histopathology analysis is of great significance for the diagnosis and prognosis of cancers, however, it has great challenges due to the enormous heterogeneity of gigapixel whole slide images (WSIs) and the intricate representation of pathological features. However, recent methods have not adequately exploited geometrical representation in WSIs which is significant in disease diagnosis. Therefore, we proposed a novel weakly-supervised framework, Geometry-Aware Transformer (GOAT), in which we urge the model to pay attention to the geometric characteristics within the tumor microenvironment which often serve as potent indicators. In addition, a context-aware attention mechanism is designed to extract and enhance the morphological features within WSIs.

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arXiv2023

MGCT: Mutual-Guided Cross-Modality Transformer for Survival Outcome Prediction using Integrative Histopathology-Genomic Features

The rapidly emerging field of deep learning-based computational pathology has shown promising results in utilizing whole slide images (WSIs) to objectively prognosticate cancer patients. However, most prognostic methods are currently limited to either histopathology or genomics alone, which inevitably reduces their potential to accurately predict patient prognosis. Whereas integrating WSIs and genomic features presents three main challenges: (1) the enormous heterogeneity of gigapixel WSIs which can reach sizes as large as 150,000x150,000 pixels; (2) the absence of a spatially corresponding relationship between histopathology images and genomic molecular data; and (3) the existing early, late, and intermediate multimodal feature fusion strategies struggle to capture the explicit interactions between WSIs and genomics. To ameliorate these issues, we propose the Mutual-Guided Cross-Modality Transformer (MGCT), a weakly-supervised, attention-based multimodal learning framework that can combine histology features and genomic features to model the genotype-phenotype interactions within the tumor microenvironment. To validate the effectiveness of MGCT, we conduct experiments using nearly 3,600 gigapixel WSIs across five different cancer types sourced from The Cancer Genome Atlas (TCGA). Extensive experimental results consistently emphasize that MGCT outperforms the state-of-the-art (SOTA) methods.

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arXiv2021

IKEA Object State Dataset: A 6DoF object pose estimation dataset and benchmark for multi-state assembly objects

Utilizing 6DoF(Degrees of Freedom) pose information of an object and its components is critical for object state detection tasks. We present IKEA Object State Dataset, a new dataset that contains IKEA furniture 3D models, RGBD video of the assembly process, the 6DoF pose of furniture parts and their bounding box. The proposed dataset will be available at https://github.com/mxllmx/IKEAObjectStateDataset.

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