Mingyang He | Searcharxiv

arXiv2026

Broadband terahertz comb with sub-Hz comb linewidth

Terahertz (THz) frequency combs are increasingly essential for spectroscopy, metrology, and quantum science. However, generating a dense array of evenly spaced ultra-narrow THz comb lines is challenging. Here, we demonstrate broadband THz comb generation using a photoconductive antenna that transfers a noise-suppressed near-infrared electro-optical (EO) comb into the THz domain. Our noise-suppression strategy, leveraging soliton self-frequency shift and spectral filtering, effectively suppresses EO comb phase noise without requiring active stabilization. The resulting THz comb exhibits broad spectral coverage (0.05-4 THz), narrow comb linewidths (0.3 Hz at the Fourier-transform limit), and excellent frequency stability (8.6*10^-14 at 1-second integration). We further demonstrate asynchronous THz time-domain spectroscopy, resolving ~36,000 comb lines with 50 MHz spacing. Crucially, the inherent frequency agility of the EO comb enables rapid and wide-range tuning of the THz comb line spacing. These attributes position our THz comb as a versatile tool for high-resolution molecular spectroscopy and precision THz metrology.

physics.optics↗

arXiv2025

A Fully Automatic Framework for Intracranial Pressure Grading: Integrating Keyframe Identification, ONSD Measurement and Clinical Data

Intracranial pressure (ICP) elevation poses severe threats to cerebral function, thus necessitating monitoring for timely intervention. While lumbar puncture is the gold standard for ICP measurement, its invasiveness and associated risks drive the need for non-invasive alternatives. Optic nerve sheath diameter (ONSD) has emerged as a promising biomarker, as elevated ICP directly correlates with increased ONSD. However, current clinical practices for ONSD measurement suffer from inconsistency in manual operation, subjectivity in optimal view selection, and variability in thresholding, limiting their reliability. To address these challenges, we introduce a fully automatic two-stage framework for ICP grading, integrating keyframe identification, ONSD measurement and clinical data. Specifically, the fundus ultrasound video processing stage performs frame-level anatomical segmentation, rule-based keyframe identification guided by an international consensus statement, and precise ONSD measurement. The intracranial pressure grading stage then fuses ONSD metrics with clinical features to enable the prediction of ICP grades, thereby demonstrating an innovative blend of interpretable ultrasound analysis and multi-source data integration for objective clinical evaluation. Experimental results demonstrate that our method achieves a validation accuracy of $0.845 \pm 0.071$ (with standard deviation from five-fold cross-validation) and an independent test accuracy of 0.786, significantly outperforming conventional threshold-based method ($0.637 \pm 0.111$ validation accuracy, $0.429$ test accuracy). Through effectively reducing operator variability and integrating multi-source information, our framework establishes a reliable non-invasive approach for clinical ICP evaluation, holding promise for improving patient management in acute neurological conditions.

cs.CV↗