arXiv subjects

Mingzhou Chen

Publications and source records attributed to Mingzhou Chen.

8 recordsLinked to original sources

arXiv2021

Optical trapping with structured light

Optical trapping describes the interaction between light and matter to manipulate micro-objects through momentum transfer. In the case of 3D trapping with a single beam, this is termed optical tweezers. Optical tweezers are a powerful and non-invasive tool for manipulating small objects, which have become indispensable in many fields, including physics, biology, soft condensed matter, amongst others. In the early days, optical trapping were typically used with a single Gaussian beam. In recent years, we have witnessed the rapid progress in the use of structured light beams with customized phase, amplitude and polarization in optical trapping. Unusual beam properties, such as phase singularities on-axis, propagation invariant nature, have opened up novel capabilities to the study of micromanipulation in liquid, air and vacuum. In this review, we summarize the recent advances in the field of optical trapping using structured light beams.

physics.optics↗

arXiv2020

Through-Bottle Whisky Sensing and Classification using Raman Spectroscopy in an Axicon-Based Backscattering Configuration

Non-intrusive detection systems have the potential to characterise materials through various transparent glass and plastic containers. Food and drink adulteration is increasingly problematic, representing a serious health risk as well as an economic issue. This is of particular concern for alcoholic spirits such as Scotch whisky which are often targeted for fraudulent activity. We have developed a Raman system with a novel geometry of excitation and collection, exploiting the beam propagation from an axicon lens resulting in an annular beam that transforms to a Bessel illumination within the sample. This facilitates the efficient acquisition of Raman signals from the alcoholic spirit contained inside the bottle, while avoiding the collection of auto-fluorescence signals generated by the bottle wall. Therefore, this technique provides a way of non-destructive and non-contact detection to precisely analyse the contents without the requirement to open the bottle.

physics.ins-det↗

arXiv2019

Femtometer-resolved simultaneous measurement of multiple laser wavelengths in a speckle wavemeter

Many areas of optical science require an accurate measurement of optical spectra. Devices based on laser speckle promise compact wavelength measurement, with attometer-level sensitivity demonstrated for single wavelength laser fields. The measurement of multimode spectra using this approach would be attractive, yet this is currently limited to picometer resolution. Here, we present a method to improve the resolution and precision of speckle-based multi-wavelength measurements. We measure multiple wavelengths simultaneously, in a device comprising a single 1 m-long step-index multimode fiber and a fast camera. Independent wavelengths separated by as little as 1 fm are retrieved with 0.2 fm precision using Principal Component Analysis. The method offers a viable way to measure sparse spectra containing multiple individual lines and is likely to find application in the tracking of multiple lasers in fields such as portable quantum technologies and optical telecommunications.

physics.optics↗

arXiv2019

Overcoming the speckle correlation limit to achieve a fiber wavemeter with attometer resolution

The measurement of the wavelength of light using speckle is a promising tool for the realization of compact and precise wavemeters and spectrometers. However, the resolution of these devices is limited by strong correlations between the speckle patterns produced by closely-spaced wavelengths. Here, we show how principal component analysis of speckle images provides a route to overcome this limit. Using this, we demonstrate a compact wavemeter which measures wavelength changes of a stabilized diode laser of 5.3 am, eight orders of magnitude below the speckle correlation limit.

physics.optics↗

arXiv2019

Optimal compressive multiphoton imaging at depth using single-pixel detection

Compressive sensing can overcome the Nyquist criterion and record images with a fraction of the usual number of measurements required. However, conventional measurement bases are susceptible to diffraction and scattering, prevalent in high-resolution microscopy. Here, we explore the random Morlet basis as an optimal set for compressive multiphoton imaging, based on its ability to minimise the space-frequency uncertainty. We implement this approach for the newly developed method of wide-field multiphoton microscopy with single-pixel detection (TRAFIX), which allows imaging through turbid media without correction. The Morlet basis is well-suited to TRAFIX at depth, and promises a route for rapid acquisition with low photodamage.

physics.optics↗

arXiv2018

Wide-Field Multiphoton Imaging Through Scattering Media Without Correction

Optical approaches to fluorescent, spectroscopic, and morphological imaging have made exceptional advances in the last decade. Super-resolution imaging and wide-field multiphoton imaging are now underpinning major advances across the biomedical sciences. While the advances have been startling, the key unmet challenge to date in all forms of optical imaging is to penetrate deeper. A number of schemes implement aberration correction or the use of complex photonics to address this need. In contrast, we approach this challenge by implementing a scheme that requires no a priori information about the medium nor its properties. Exploiting temporal focusing and single-pixel detection in our innovative scheme, we obtain wide-field two-photon images through various turbid media including a scattering phantom and tissue reaching a depth of up to seven scattering mean free path lengths. Our results show that it competes favorably with standard point-scanning two-photon imaging, with up to a fivefold improvement in signal-to-background ratio while showing significantly lower photobleaching.

physics.optics↗

arXiv2017

Label-free optical vibrational spectroscopy to detect the metabolic state of M. tuberculosis cells at the site of disease

Tuberculosis relapse is a barrier to shorter treatment. It is thought that lipid rich cells, phenotypically resistant to antibiotics, may play a major role. Most studies investigating relapse use sputum samples although tissue bacteria may play an important role. We developed a non-destructive, label-free technique combining wavelength modulated Raman (WMR) spectroscopy and fluorescence detection (Nile Red staining) to interrogate Mycobacterium tuberculosis cell state. This approach could differentiate single 'dormant' (lipid rich, LR) and 'non-dormant' (lipid poor, LP) cells with high sensitivity and specificity. We applied this to experimentally infected guinea pig lung sections and were able to distinguish both cell types showing that the LR phenotype dominates in infected tissue. Both in-vitro and ex-vivo spectra correlated well, showing for the first time that Mycobacterium tuberculosis, likely to be phenotypically resistant to antibiotics, are present in large numbers in tissue. This is an important step in understanding the pathology of relapse supporting the idea that they may be caused by M. tuberculosis cells with lipid inclusions.

physics.bio-ph↗

arXiv2006

Detection of phase singularities with a Shack-Hartmann wavefront sensor

While adaptive optical systems are able to remove moderate wavefront distortions in scintillated optical beams, phase singularities that appear in strongly scintillated beams can severely degrade the performance of such an adaptive optical system. Therefore, the detection of these phase singularities is an important aspect of strong scintillation adaptive optics. We investigate the detection of phase singularities with the aid of a Shack-Hartmann wavefront sensor and show that, in spite of some systematical deficiencies inherent to the Shack-Hartmann wavefront sensor, it can be used for the reliable detection of phase singularities, irrespective of their morphologies. We provide full analytical results, together with numerical simulations of the detection process.

physics.optics↗