arXiv subjects

Minh Doan

Publications and source records attributed to Minh Doan.

6 recordsLinked to original sources

arXiv2026

Predefined-Time Resilient Integral Reinforcement Learning for Input-Constrained Unknown Nonlinear Systems Under FDI Attacks and Disturbances: A Fully Data-Driven Approach

This paper investigates optimal control for nonlinear systems with unknown dynamics, input constraints, disturbances, and adversarial signals. The objective is to develop a learning-based control method that allows the designer to prescribe the desired convergence time in advance. An integral reinforcement-learning framework is proposed to avoid requiring exact knowledge of the system dynamics while ensuring that the control input always satisfies the actuator constraints. Current and recorded data are combined to train the critic without requiring persistent excitation. The learning gain is selected directly from the prescribed convergence deadline. Lyapunov analysis is then used to establish practical predefined-time convergence of the coupled state-critic system in the presence of disturbances and adversarial channels. The effectiveness of the proposed method is validated through the stabilization control of a two-link robot manipulator.

eess.SY↗

arXiv2026

Fixed-Time Integral Reinforcement Learning for Saturated Nonlinear Multi-Agent Systems Under FDI Attacks

The leader-follower formation control problem is investigated for nonlinear multi-agent systems with unknown dynamics, external disturbances, and false data injection (FDI) attacks on actuator channels. The problem is formulated as a zero-sum differential game and solved using the Integral Bellman-Isaacs approach. To address input saturation constraints, a non-quadratic control cost function is incorporated into the optimization problem, leading to a bounded control law. Furthermore, this paper proposes a cost function construction method and develops a critic learning law, which together guarantee the practical fixed-time stability of the system while overcoming the limitations of existing fixed-time reinforcement learning formulations. Finally, the practical fixed-time convergence of both the critic weight estimation error and the leader-referenced formation tracking error to bounded residual sets is rigorously proven. Simulation results demonstrate the effectiveness of the proposed method under external disturbances, FDI attacks, and input constraints.

eess.SY↗

arXiv2026

A Proper Scoring Rule for Virtual Staining

Generative virtual staining (VS) models for high-throughput screening (HTS) can provide an estimated posterior distribution of possible biological feature values for each input and cell. However, when evaluating a VS model, the true posterior is unavailable. Existing evaluation protocols only check the accuracy of the marginal distribution over the dataset rather than the predicted posteriors. We introduce information gain (IG) as a cell-wise evaluation framework that enables direct assessment of predicted posteriors. IG is a strictly proper scoring rule and comes with a sound theoretical motivation allowing for interpretability, and for comparing results across models and features. We evaluate diffusion- and GAN-based models on an extensive HTS dataset using IG and other metrics and show that IG can reveal substantial performance differences other metrics cannot.

cs.LG↗

arXiv2026

Changing the Optics: Comparing Traditional and Retrieval-Augmented GenAI E-Tutorials in Interdisciplinary Learning

Understanding information-seeking behaviors in e-learning is critical, as learners must often make sense of complex and fragmented information, a challenge compounded in interdisciplinary fields with diverse prior knowledge. Compared to traditional e-tutorials, GenAI e-tutorials offer new ways to navigate information spaces, yet how they shape learners information-seeking behaviors remains unclear. To address this gap, we characterized behavioral differences between traditional and GenAI-mediated e-tutorial learning using the three search modes of orienteering. We conducted a between-subject study in which learners engaged with either a traditional e-tutorial or a GenAI e-tutorial accessing the same underlying information content. We found that the traditional users maintained greater awareness and focus of the information space, whereas GenAI users exhibited more proactive and exploratory behaviors with lower cognitive load due to the querying-driven interaction. These findings offer guidance for designing tutorials in e-learning.

cs.HC↗

arXiv2025

SPAR: Session-based Pipeline for Adaptive Retrieval on Legacy File Systems

The ability to extract value from historical data is essential for enterprise decision-making. However, much of this information remains inaccessible within large legacy file systems that lack structured organization and semantic indexing, making retrieval and analysis inefficient and error-prone. We introduce SPAR (Session-based Pipeline for Adaptive Retrieval), a conceptual framework that integrates Large Language Models (LLMs) into a Retrieval-Augmented Generation (RAG) architecture specifically designed for legacy enterprise environments. Unlike conventional RAG pipelines, which require costly construction and maintenance of full-scale vector databases that mirror the entire file system, SPAR employs a lightweight two-stage process: a semantic Metadata Index is first created, after which session-specific vector databases are dynamically generated on demand. This design reduces computational overhead while improving transparency, controllability, and relevance in retrieval. We provide a theoretical complexity analysis comparing SPAR with standard LLM-based RAG pipelines, demonstrating its computational advantages. To validate the framework, we apply SPAR to a synthesized enterprise-scale file system containing a large corpus of biomedical literature, showing improvements in both retrieval effectiveness and downstream model accuracy. Finally, we discuss design trade-offs and outline open challenges for deploying SPAR across diverse enterprise settings.

cs.IR↗

arXiv2024

Can virtual staining for high-throughput screening generalize?

The large volume and variety of imaging data from high-throughput screening (HTS) in the pharmaceutical industry present an excellent resource for training virtual staining models. However, the potential of models trained under one set of experimental conditions to generalize to other conditions remains underexplored. This study systematically investigates whether data from three cell types (lung, ovarian, and breast) and two phenotypes (toxic and non-toxic conditions) commonly found in HTS can effectively train virtual staining models to generalize across three typical HTS distribution shifts: unseen phenotypes, unseen cell types, and the combination of both. Utilizing a dataset of 772,416 paired bright-field, cytoplasm, nuclei, and DNA-damage stain images, we evaluate the generalization capabilities of models across pixel-based, instance-wise, and biological-feature-based levels. Our findings indicate that training virtual nuclei and cytoplasm models on non-toxic condition samples not only generalizes to toxic condition samples but leads to improved performance across all evaluation levels compared to training on toxic condition samples. Generalization to unseen cell types shows variability depending on the cell type; models trained on ovarian or lung cell samples often perform well under other conditions, while those trained on breast cell samples consistently show poor generalization. Generalization to unseen cell types and phenotypes shows good generalization across all levels of evaluation compared to addressing unseen cell types alone. This study represents the first large-scale, data-centric analysis of the generalization capability of virtual staining models trained on diverse HTS datasets, providing valuable strategies for experimental training data generation.

cs.LG↗