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Minjie Yang

Publications and source records attributed to Minjie Yang.

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Conformal Prediction for Dyadic Regression Under Complex Missingness

We develop a framework for conformal prediction in dyadic regression problems under complex missingness mechanisms. At the theoretical level, we develop general technical tools for establishing finite-sample validity of conformal prediction under distributional invariance conditions weaker than exchangeability. A key result handles the case where the sample itself is a random subset of the index set, a setting not covered by existing theory, via a novel bijection argument that constructs an explicit measure-preserving correspondence between events. In addition, we propose conformal prediction procedures for jointly exchangeable arrays, including full conformal, split conformal, a row-column approach exploiting similarities within rows and columns, and a selective conformal procedure achieving mask-conditional validity. For missing elements, we establish asymptotic validity of a weighted conformal procedure under a nonparametric graphon model for the missingness mechanism. We further establish conditional validity results for both continuous and discrete responses; to the best of our knowledge, this is the first formal proof of asymptotic conditional validity for weighted conformal prediction under a missing-not-at-random assumption. The proposed methods are illustrated on synthetic and real network data.

math.ST

A Dual Radiomic and Dosiomic Filtering Technique for Locoregional Radiation Pneumonitis Prediction in Breast Cancer Patients

Purpose: Radiation pneumonitis (RP) is a serious complication of intensity-modulated radiation therapy (IMRT) for breast cancer patients, underscoring the need for precise and explainable predictive models. This study presents an Explainable Dual-Omics Filtering (EDOF) model that integrates spatially localized dosiomic and radiomic features for voxel-level RP prediction. Methods: A retrospective cohort of 72 breast cancer patients treated with IMRT was analyzed, including 28 who developed RP. The EDOF model consists of two components: (1) dosiomic filtering, which extracts local dose intensity and spatial distribution features from planning dose maps, and (2) radiomic filtering, which captures texture-based features from pre-treatment CT scans. These features are jointly analyzed using the Explainable Boosting Machine (EBM), a transparent machine learning model that enables feature-specific risk evaluation. Model performance was assessed using five-fold cross-validation, reporting area under the curve (AUC), sensitivity, and specificity. Feature importance was quantified by mean absolute scores, and Partial Dependence Plots (PDPs) were used to visualize nonlinear relationships between RP risk and dual-omic features. Results: The EDOF model achieved strong predictive performance (AUC = 0.95 +- 0.01; sensitivity = 0.81 +- 0.05). The most influential features included dosiomic Intensity Mean, dosiomic Intensity Mean Absolute Deviation, and radiomic SRLGLE. PDPs revealed that RP risk increases beyond 5 Gy and rises sharply between 10-30 Gy, consistent with clinical dose thresholds. SRLGLE also captured structural heterogeneity linked to RP in specific lung regions. Conclusion: The EDOF framework enables spatially resolved, explainable RP prediction and may support personalized radiation planning to mitigate pulmonary toxicity.

physics.med-ph