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Minkyung Lee

Publications and source records attributed to Minkyung Lee.

11 recordsLinked to original sources

K-EXAONE 2.0 Technical Report

This technical report presents K-EXAONE 2.0, an open-weight multilingual foundation model developed by LG AI Research as a step in our effort toward global frontier-scale foundation models. Rather than training from scratch, we upcycle K-EXAONE and expand its architecture, yielding a Mixture-of-Experts (MoE) model with 750B total parameters and approximately 37B activated per token---more than three times the capacity of its predecessor. K-EXAONE 2.0 supports context lengths of up to 256K tokens and expands multilingual coverage from six to ten languages. Its training pipeline combines continual pre-training, difficulty-focused mid-training, and post-training to strengthen reasoning, agentic coding, multilingual capability, and safety grounded in Korean sociocultural contexts. Across nine evaluation categories selected to reflect the conditions of practical use, K-EXAONE 2.0 improves over K-EXAONE and remains competitive with open-weight models, showing its largest gains in agentic coding and long-context understanding and its clearest strengths in long-context retrieval and safety. Released under the Apache 2.0 license, K-EXAONE 2.0 enables the wider AI ecosystem to evaluate, deploy, adapt, and build upon it, while marking the beginning---rather than the endpoint---of our challenge toward the global frontier.

cs.CL

Fine-UNETR for PSMA PET/CT Lesion Segmentation: Automated Tumor Quantification and Overall Survival Stratification in Prostate Cancer

Introduction: To develop and evaluate Fine-UNETR, a Vision Transformer-based architecture for automated segmentation of PSMA-avid lesions on whole-body PET/CT, and to assess clinical utility of AI-derived tumor burden biomarkers for overall survival stratification in radioligand therapy. Methods: In this retrospective study, 373 PSMA PET/CT scans (mean age, 71+-8 years) from patients with prostate cancer were analyzed. Fine-UNETR, a modified UNETR with 8x8x8 voxel patch embedding and axial sliding window training, was trained on 299 scans and validated on 74 scans. Overall survival stratification was assessed in an independent cohort of 67 pre-radioligand therapy patients using Kaplan-Meier analysis and log-rank testing. External validation was performed on 192 cases from the AutoPET IV PSMA PET/CT dataset. Results: Fine-UNETR achieved a Dice similarity coefficient (DSC) of 66.63%, sensitivity of 70.27%, precision of 67.77%, and a lesion detection rate of 79.53% (96.05% for lesions with SUVmax >= 5). On the external validation dataset, the model achieved a DSC of 44.11% and a lesion detection rate of 87.18%, indicating that lesion detection performance was preserved despite reduced voxel-level overlap. AI-derived biomarkers showed excellent agreement with ground truth (total tumor volume: r=0.984; total lesion uptake: r=0.989; lesion count: r=0.960). In the clinical cohort, total tumor volume (p=0.0019), SUVmax (p=0.014), and SUVmean (p=0.016) significantly stratified overall survival. Conclusion: Fine-UNETR enables accurate automated whole-body PSMA lesion segmentation and tumor burden quantification. Performance on an external dataset demonstrates robustness despite evidence of domain shift. AI-derived biomarkers significantly stratified overall survival in a pre-radioligand therapy cohort, supporting the clinical utility of automated PSMA PET/CT quantification for prognostication.

eess.IV

Electron-wave-stimulated mid-infrared emission from graphene-substrate quantum oscillators

Generating tunable, high-intensity mid-infrared (MIR) to terahertz (THz) radiation on-chip remains a formidable challenge due to the rigid spectral limits of conventional thermal emitters. While graphene has emerged as a promising platform for light-matter interaction, active control of its radiative properties has been largely confined to surface-limited phenomena mostly associated with plasmons. Here, we introduce a new MIR radiation platform where multi-layer chemical vapor deposition (CVD) graphene is integrated with modular, vibrationally active dielectric substrates, ranging from organic thin films and inorganic matrices. A pivotal discovery is that the long-range de Broglie wavelength of drift carriers enables coherent coupling with vibrational transition dipoles deep within the substrate bulk. This transforms the substrate into a three-dimensional volume emission source, where complex spectra of characteristic molecular and lattice vibration energies are additively combined on demand. The exponential scaling of radiation intensity appears when the electrons' drift velocity in graphene exceeds the sound velocity of the substrates, consistent with quantum stimulated amplification associated with Cerenkov electron-phonon instability. Our work redefines the passive dielectric substrate as an active, programmable component driven by electron waves, paving the way for next-generation system-on-a-chip MIR-THz photonics, environmental and biomedical sensing, and highly efficient mode-specific electrothermal applications.

physics.chem-ph

G2L:From Giga-Scale to Cancer-Specific Large-Scale Pathology Foundation Models via Knowledge Distillation

Recent studies in pathology foundation models have shown that scaling training data, diversifying cancer types, and increasing model size consistently improve their performance. However, giga-scale foundation models, which are trained on hundreds of thousands of slides covering tens of cancer types and contain billions of parameters, pose significant challenges for practical use due to their tremendous computational costs in both development and deployment. In this work, we present a novel strategy, named the G2L framework, to increase the performance of large-scale foundation models, which consist of only $15\%$ of the parameters of giga-scale models, to a comparable performance level of giga-scale models in cancer-specific tasks. Our approach applies knowledge distillation, transferring the capabilities of a giga-scale model to a large-scale model, using just 1K pathology slides of a target cancer (e.g., breast, prostate, etc.). The resulting distilled model not only outperformed state-of-the-art models of the same size (i.e., large-scale) across several benchmarks but also, interestingly, surpassed the giga-scale teacher and huge-scale models in some benchmarks. In addition, the distilled model exhibited a higher robustness index, indicating improved resilience to image variations originating from multiple institutions. These findings suggest that the proposed distillation approach for a large-scale model is a data- and parameter-efficient way to achieve giga-scale-level performance for cancer-specific applications without prohibitive computational burden.

cs.CV

3DTeethSeg'22: 3D Teeth Scan Segmentation and Labeling Challenge

Teeth localization, segmentation, and labeling from intra-oral 3D scans are essential tasks in modern dentistry to enhance dental diagnostics, treatment planning, and population-based studies on oral health. However, developing automated algorithms for teeth analysis presents significant challenges due to variations in dental anatomy, imaging protocols, and limited availability of publicly accessible data. To address these challenges, the 3DTeethSeg'22 challenge was organized in conjunction with the International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI) in 2022, with a call for algorithms tackling teeth localization, segmentation, and labeling from intraoral 3D scans. A dataset comprising a total of 1800 scans from 900 patients was prepared, and each tooth was individually annotated by a human-machine hybrid algorithm. A total of 6 algorithms were evaluated on this dataset. In this study, we present the evaluation results of the 3DTeethSeg'22 challenge. The 3DTeethSeg'22 challenge code can be accessed at: https://github.com/abenhamadou/3DTeethSeg22_challenge

cs.CV

Tooth Instance Segmentation from Cone-Beam CT Images through Point-based Detection and Gaussian Disentanglement

Individual tooth segmentation and identification from cone-beam computed tomography images are preoperative prerequisites for orthodontic treatments. Instance segmentation methods using convolutional neural networks have demonstrated ground-breaking results on individual tooth segmentation tasks, and are used in various medical imaging applications. While point-based detection networks achieve superior results on dental images, it is still a challenging task to distinguish adjacent teeth because of their similar topologies and proximate nature. In this study, we propose a point-based tooth localization network that effectively disentangles each individual tooth based on a Gaussian disentanglement objective function. The proposed network first performs heatmap regression accompanied by box regression for all the anatomical teeth. A novel Gaussian disentanglement penalty is employed by minimizing the sum of the pixel-wise multiplication of the heatmaps for all adjacent teeth pairs. Subsequently, individual tooth segmentation is performed by converting a pixel-wise labeling task to a distance map regression task to minimize false positives in adjacent regions of the teeth. Experimental results demonstrate that the proposed algorithm outperforms state-of-the-art approaches by increasing the average precision of detection by 9.1%, which results in a high performance in terms of individual tooth segmentation. The primary significance of the proposed method is two-fold: 1) the introduction of a point-based tooth detection framework that does not require additional classification and 2) the design of a novel loss function that effectively separates Gaussian distributions based on heatmap responses in the point-based detection framework.

cs.CV

Individual Tooth Detection and Identification from Dental Panoramic X-Ray Images via Point-wise Localization and Distance Regularization

Dental panoramic X-ray imaging is a popular diagnostic method owing to its very small dose of radiation. For an automated computer-aided diagnosis system in dental clinics, automatic detection and identification of individual teeth from panoramic X-ray images are critical prerequisites. In this study, we propose a point-wise tooth localization neural network by introducing a spatial distance regularization loss. The proposed network initially performs center point regression for all the anatomical teeth (i.e., 32 points), which automatically identifies each tooth. A novel distance regularization penalty is employed on the 32 points by considering $L_2$ regularization loss of Laplacian on spatial distances. Subsequently, teeth boxes are individually localized using a cascaded neural network on a patch basis. A multitask offset training is employed on the final output to improve the localization accuracy. Our method successfully localizes not only the existing teeth but also missing teeth; consequently, highly accurate detection and identification are achieved. The experimental results demonstrate that the proposed algorithm outperforms state-of-the-art approaches by increasing the average precision of teeth detection by 15.71% compared to the best performing method. The accuracy of identification achieved a precision of 0.997 and recall value of 0.972. Moreover, the proposed network does not require any additional identification algorithm owing to the preceding regression of the fixed 32 points regardless of the existence of the teeth.

cs.CV

Pose-Aware Instance Segmentation Framework from Cone Beam CT Images for Tooth Segmentation

Individual tooth segmentation from cone beam computed tomography (CBCT) images is an essential prerequisite for an anatomical understanding of orthodontic structures in several applications, such as tooth reformation planning and implant guide simulations. However, the presence of severe metal artifacts in CBCT images hinders the accurate segmentation of each individual tooth. In this study, we propose a neural network for pixel-wise labeling to exploit an instance segmentation framework that is robust to metal artifacts. Our method comprises of three steps: 1) image cropping and realignment by pose regressions, 2) metal-robust individual tooth detection, and 3) segmentation. We first extract the alignment information of the patient by pose regression neural networks to attain a volume-of-interest (VOI) region and realign the input image, which reduces the inter-overlapping area between tooth bounding boxes. Then, individual tooth regions are localized within a VOI realigned image using a convolutional detector. We improved the accuracy of the detector by employing non-maximum suppression and multiclass classification metrics in the region proposal network. Finally, we apply a convolutional neural network (CNN) to perform individual tooth segmentation by converting the pixel-wise labeling task to a distance regression task. Metal-intensive image augmentation is also employed for a robust segmentation of metal artifacts. The result shows that our proposed method outperforms other state-of-the-art methods, especially for teeth with metal artifacts. The primary significance of the proposed method is two-fold: 1) an introduction of pose-aware VOI realignment followed by a robust tooth detection and 2) a metal-robust CNN framework for accurate tooth segmentation.

cs.CV

Deeply Self-Supervised Contour Embedded Neural Network Applied to Liver Segmentation

Objective: Herein, a neural network-based liver segmentation algorithm is proposed, and its performance was evaluated using abdominal computed tomography (CT) images. Methods: A fully convolutional network was developed to overcome the volumetric image segmentation problem. To guide a neural network to accurately delineate a target liver object, the network was deeply supervised by applying the adaptive self-supervision scheme to derive the essential contour, which acted as a complement with the global shape. The discriminative contour, shape, and deep features were internally merged for the segmentation results. Results and Conclusion: 160 abdominal CT images were used for training and validation. The quantitative evaluation of the proposed network was performed through an eight-fold cross-validation. The result showed that the method, which uses the contour feature, segmented the liver more accurately than the state-of-the-art with a 2.13% improvement in the dice score. Significance: In this study, a new framework was introduced to guide a neural network and learn complementary contour features. The proposed neural network demonstrates that the guided contour features can significantly improve the performance of the segmentation task.

cs.CV

Direct observation of the M2 phase with its Mott transition in a VO$_2$ film

In VO$_2$, the explicit origin of the insulator-to-metal transition is still disputable between Peierls and Mott insulators. Along with the controversy, its second monoclinic (M2) phase has received considerable attention due to the presence of electron correlation in undimerized vanadium ions. However, the origin of the M2 phase is still obscure. Here, we study a granular VO$_2$ film using conductive atomic force microscopy and Raman scattering. Upon the structural transition from monoclinic to rutile, we observe directly an intermediate state showing the coexistence of monoclinic M1 and M2 phases. The conductivity near the grain boundary in this regime is six times larger than that of the grain core, producing a donut-like landscape. Our results reveal an intra-grain percolation process, indicating that VO$_2$ with the M2 phase is a Mott insulator.

cond-mat.str-el

Spatially resolved penetration depth measurements and vortex manipulation in the ferromagnetic superconductor ErNi2B2C

We present a local probe study of the magnetic superconductor, ErNi$_2$B$_2$C, using magnetic force microscopy at sub-Kelvin temperatures. ErNi$_2$B$_2$C is an ideal system to explore the effects of concomitant superconductivity and ferromagnetism. At 500 mK, far below the transition to a weakly ferromagnetic state, we directly observe a structured magnetic background on the micrometer scale. We determine spatially resolved absolute values of the magnetic penetration depth $λ$ and study its temperature dependence as the system undergoes magnetic phase transitions from paramagnetic to antiferromagnetic, and to weak ferromagnetic, all within the superconducting regime. In addition, we estimate the absolute pinning force of Abrikosov vortices, which shows a position- and temperature dependence as well, and discuss the possibility of the purported spontaneous vortex formation.

cond-mat.supr-con