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Minxuan Wu

Publications and source records attributed to Minxuan Wu.

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Partial identification of principal causal effects under violations of principal ignorability

Principal stratification is a general framework for studying causal mechanisms involving post-treatment variables. When estimating principal causal effects, the principal ignorability assumption is commonly invoked, which we study in detail in this manuscript. Our first key contribution is studying a commonly used strategy of using parametric models to jointly model the outcome and principal strata without requiring the principal ignorability assumption. We show that even if the joint distribution of principal strata is known, this strategy necessarily leads to only partial identification of causal effects, even under very simple and correctly specified outcome models. While principal ignorability leads to point identification in this setting, we discuss alternative, weaker assumptions and show how they can lead to informative partial identification regions. An additional contribution is that we provide theoretical support to strategies used in the literature for identifying association parameters that govern the joint distribution of principal strata. We prove that this is possible, but only if the principal ignorability assumption is violated. Additionally, due to partial identifiability of causal effects even when these association parameters are known, we show that these association parameters are only identifiable under strong parametric constraints. Lastly, we extend these results to more flexible semiparametric and nonparametric Bayesian models.

stat.ME

Envelope-based partial least squares in functional regression

In this article, we extend predictor envelope models to settings with multivariate outcomes and multiple, functional predictors. We propose a two-step estimation strategy, which first projects the function onto a finite-dimensional Euclidean space before fitting the model using existing approaches to envelope models. We first develop an estimator under a linear model with continuous outcomes and then extend this procedure to the more general class of generalized linear models, which allow for a variety of outcome types. We provide asymptotic theory for these estimators showing that they are root-$n$ consistent and asymptotically normal when the regression coefficient is finite-rank. Additionally we show that consistency can be obtained even when the regression coefficient has rank that grows with the sample size. Extensive simulation studies confirm our theoretical results and show strong prediction performance of the proposed estimators. Additionally, we provide multiple data analyses showing that the proposed approach performs well in real-world settings under a variety of outcome types compared with existing dimension reduction approaches.

stat.ME

Principal stratification with continuous treatments and continuous post-treatment variables

Principal stratification (PS) is a commonly used approach for understanding the mechanisms through which a treatment affects an outcome. The goal of this work is to extend the PS framework to studies with continuous treatments, which introduces a number of both challenges and opportunities in terms of defining causal effects and performing inference. This manuscript provides multiple key methodological contributions: 1) we introduce principal causal estimands for continuous treatments that provide insights into different causal mechanisms, 2) we show that nonparametric identification is possible under a principal ignorability assumption, but only under a restrictive assumption on the joint distribution of potential mediators, which can be dropped under mild parametric assumptions, 3) we utilize nonparametric Bayesian models for the joint distribution of the potential mediating variables to ensure our approach is robust to model misspecification, and 4) we provide theoretical justification for utilizing an outcome model to identify the joint distribution of the potential mediating variables, and show that this is only possible if a principal ignorability assumption is violated. Lastly, we apply our methodology to a novel study of the relationship between the economy and arrest rates, and how this is potentially mediated by police capacity.

stat.ME