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Mitchell Pavlak

Publications and source records attributed to Mitchell Pavlak.

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Detecting Dataset Bias in Medical AI: A Generalized and Modality-Agnostic Auditing Framework

Artificial Intelligence (AI) is now firmly at the center of evidence-based medicine. Despite many success stories that edge the path of AI's rise in healthcare, there are comparably many reports of significant shortcomings and unexpected behavior of AI in deployment. A major reason for these limitations is AI's reliance on association-based learning, where non-representative machine learning datasets can amplify latent bias during training and/or hide it during testing. To unlock new tools capable of foreseeing and preventing such AI bias issues, we present G-AUDIT. Generalized Attribute Utility and Detectability-Induced bias Testing (G-AUDIT) for datasets is a modality-agnostic dataset auditing framework that allows for generating targeted hypotheses about sources of bias in training or testing data. Our method examines the relationship between task-level annotations (commonly referred to as ``labels'') and data properties including patient attributes (e.g., age, sex) and environment/acquisition characteristics (e.g., clinical site, imaging protocols). G-AUDIT quantifies the extent to which the observed data attributes pose a risk for shortcut learning, or in the case of testing data, might hide predictions made based on spurious associations. We demonstrate the broad applicability of our method by analyzing large-scale medical datasets for three distinct modalities and machine learning tasks: skin lesion classification in images, stigmatizing language classification in Electronic Health Records (EHR), and mortality prediction for ICU tabular data. In each setting, G-AUDIT successfully identifies subtle biases commonly overlooked by traditional qualitative methods, underscoring its practical value in exposing dataset-level risks and supporting the downstream development of reliable AI systems.

cs.LG

Explainable AI Enhances Glaucoma Referrals, Yet the Human-AI Team Still Falls Short of the AI Alone

Primary care providers are vital for initial triage and referrals to specialty care. In glaucoma, asymptomatic and fast progression can lead to vision loss, necessitating timely referrals to specialists. However, primary eye care providers may not identify urgent cases, potentially delaying care. Artificial Intelligence (AI) offering explanations could enhance their referral decisions. We investigate how various AI explanations help providers distinguish between patients needing immediate or non-urgent specialist referrals. We built explainable AI algorithms to predict glaucoma surgery needs from routine eyecare data as a proxy for identifying high-risk patients. We incorporated intrinsic and post-hoc explainability and conducted an online study with optometrists to assess human-AI team performance, measuring referral accuracy and analyzing interactions with AI, including agreement rates, task time, and user experience perceptions. AI support enhanced referral accuracy among 87 participants (59.9%/50.8% with/without AI), though Human-AI teams underperformed compared to AI alone. Participants believed they included AI advice more when using the intrinsic model, and perceived it more useful and promising. Without explanations, deviations from AI recommendations increased. AI support did not increase workload, confidence, and trust, but reduced challenges. On a separate test set, our black-box and intrinsic models achieved an accuracy of 77% and 71%, respectively, in predicting surgical outcomes. We identify opportunities of human-AI teaming for glaucoma management in primary eye care, noting that while AI enhances referral accuracy, it also shows a performance gap compared to AI alone, even with explanations. Human involvement remains essential in medical decision making, underscoring the need for future research to optimize collaboration, ensuring positive experiences and safe AI use.

cs.HC

Data AUDIT: Identifying Attribute Utility- and Detectability-Induced Bias in Task Models

To safely deploy deep learning-based computer vision models for computer-aided detection and diagnosis, we must ensure that they are robust and reliable. Towards that goal, algorithmic auditing has received substantial attention. To guide their audit procedures, existing methods rely on heuristic approaches or high-level objectives (e.g., non-discrimination in regards to protected attributes, such as sex, gender, or race). However, algorithms may show bias with respect to various attributes beyond the more obvious ones, and integrity issues related to these more subtle attributes can have serious consequences. To enable the generation of actionable, data-driven hypotheses which identify specific dataset attributes likely to induce model bias, we contribute a first technique for the rigorous, quantitative screening of medical image datasets. Drawing from literature in the causal inference and information theory domains, our procedure decomposes the risks associated with dataset attributes in terms of their detectability and utility (defined as the amount of information knowing the attribute gives about a task label). To demonstrate the effectiveness and sensitivity of our method, we develop a variety of datasets with synthetically inserted artifacts with different degrees of association to the target label that allow evaluation of inherited model biases via comparison of performance against true counterfactual examples. Using these datasets and results from hundreds of trained models, we show our screening method reliably identifies nearly imperceptible bias-inducing artifacts. Lastly, we apply our method to the natural attributes of a popular skin-lesion dataset and demonstrate its success. Our approach provides a means to perform more systematic algorithmic audits and guide future data collection efforts in pursuit of safer and more reliable models.

cs.LG