Mohammad Hridoy Patwary

arXiv2026

Quantifying Inconsistent Mediation: The Mediated Magnitude Share and the Degree of Suppression

The proportion mediated (PM), defined as the indirect effect divided by the total effect, is intuitive when direct and indirect effects operate in the same direction. Under inconsistent mediation, however, opposing pathways partially cancel each other, causing PM to fall outside the unit interval or become unstable as the total effect approaches zero. We introduce two complementary effect-scale measures: the Mediated Magnitude Share (MMS), which quantifies the absolute magnitude of an indirect pathway relative to the combined absolute magnitudes of the direct and indirect pathways, and the degree of suppression, which quantifies the fraction of this combined magnitude that is cancelled by opposing pathways. We establish the bounds and limiting behavior of both measures in the two-pathway case, show that MMS reduces to PM under consistent mediation, and extend both measures to settings with multiple indirect pathways. For binary outcomes, we extend the framework to odds-ratio and risk-ratio scales by using logarithms to convert multiplicative effects into additive ones, enabling direct application of MMS and the degree of suppression. Together, these measures provide bounded and interpretable characterizations of mediation systems in which pathway directions are not uniform.

stat.ME↗

arXiv2026

Causal Inference with MNAR Self-Masking Confounders: A Stratified Delta-Imputed Propensity Estimation Method

In observational studies, causal inference becomes difficult when confounders are missing-not-at-random (MNAR), particularly where the missingness depends on the confounder's own unreported value (self-masking). Existing methods for handling MNAR confounders often rely on strong, unverifiable assumptions, leading to biased estimates. We propose a simple approach with Stratified Delta-Imputed Propensity Estimator (SDIPE) in the presence of self-masking confounders. SDIPE first stratifies data into observed and missing groups, imputes missing confounders via delta-adjusted multiple imputation. Then, within each group, average-treatment-effects (ATEs) are estimated by stabilized-inverse-probability-weights. The final ATE is obtained by combining the subgroup-specific estimates, weighted by respective proportions in the sample. Simulation study shows that SDIPE achieves low bias and near-nominal coverage (94-96%) across varying missingness, sample sizes, and treatment prevalence. In contrast, conventional sensitivity-based multiple imputation exhibits substantial bias and poor coverage (18-89%). Additionally, SDIPE is robust to the choice of the delta parameter. Applied to NHANES-2017-2018, SDIPE estimates that married individuals have a 1.19-point lower depression score than unmarried individuals (95% CI: -1.76, -0.64), adjusting for MNAR income data. SDIPE provides a practical and robust approach for causal inference with self-masking MNAR confounders, offering improved performance over existing methods without requiring restrictive assumptions about the missingness mechanism.

stat.ME↗