arXiv subjects

Monica Luo

Publications and source records attributed to Monica Luo.

2 recordsLinked to original sources

arXiv2026

Beyond the Tumor: Recurrence-Prone Radiomics for Prognostication in Negative PSMA PET/CT scans of Prostate Cancer

In patients with biochemical recurrence of prostate cancer and negative PSMA PET/CT, radiomics features extracted from recurrence-prone organs can predict clinical progression and progression-free survival. In a cohort of 132 patients, combining PET/CT radiomics with clinical variables significantly improved prognostic performance (C-index 0.74 vs. 0.65). Model performance was influenced by reader diagnostic certainty and remained robust on external validation. These findings suggest that radiomics from visually negative scans capture subclinical disease and provide added value for risk stratification.

physics.med-ph↗

arXiv2025

Towards Integrated Clinical-Computational Nuclear Medicine

The field of Clinical-Computational Nuclear Medicine is rapidly advancing, fueled by AI, tracer kinetic modeling, radiomics, and integrated informatics. These technologies improve imaging quality, automate lesion detection, and enable personalized radiopharmaceutical therapy through physiologically based pharmacokinetic (PBPK) modeling and voxel-level dosimetry. Workflow automation and Natural Language Processing (NLP) further enhance operational efficiency. However, successful implementation and adoption of these tools require clinical oversight to ensure accuracy, interpretability, and patient safety. This paper highlights key computational innovations and emphasizes the critical role of clinician-guided evaluation in shaping the future of precision imaging and therapy.

physics.med-ph↗