Moon Hwan Lee | Searcharxiv

arXiv2026

High-Fidelity Transcranial Ultrasound Multi-focal Stimulation via Physics-Aware Hologram Technique

Transcranial ultrasound stimulation (TUS) offers non-invasive deep-brain neuromodulation with high spatial precision, but reliably generating complex multi-target acoustic fields through the skull remains challenging. Here, we introduce a physics-aware hologram technique that directly generates fabrication-ready holographic implementations while preserving consistency between numerical field synthesis and physical acoustic realization. The method enables single-, dual-, and tri-focal transcranial stimulation patterns and was validated through in silico simulations, ex vivo skull measurements, and in vivo experiments. Compared with representative state-of-the-art methods, the proposed approach improved focal reconstruction and energy confinement at intended targets while reducing off-target acoustic leakage. In a neuropathic-pain mouse model, simultaneous bilateral stimulation of thalamic nuclei reduced c-Fos expression and showed preliminary improvements in pain-related behavioral responses. These findings support the use of fabrication-consistent holographic design for spatially localized and reproducible multi-target transcranial neuromodulation.

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arXiv2023

Deep Learning-based Synthetic High-Resolution In-Depth Imaging Using an Attachable Dual-element Endoscopic Ultrasound Probe

Endoscopic ultrasound (EUS) imaging has a trade-off between resolution and penetration depth. By considering the in-vivo characteristics of human organs, it is necessary to provide clinicians with appropriate hardware specifications for precise diagnosis. Recently, super-resolution (SR) ultrasound imaging studies, including the SR task in deep learning fields, have been reported for enhancing ultrasound images. However, most of those studies did not consider ultrasound imaging natures, but rather they were conventional SR techniques based on downsampling of ultrasound images. In this study, we propose a novel deep learning-based high-resolution in-depth imaging probe capable of offering low- and high-frequency ultrasound image pairs. We developed an attachable dual-element EUS probe with customized low- and high-frequency ultrasound transducers under small hardware constraints. We also designed a special geared structure to enable the same image plane. The proposed system was evaluated with a wire phantom and a tissue-mimicking phantom. After the evaluation, 442 ultrasound image pairs from the tissue-mimicking phantom were acquired. We then applied several deep learning models to obtain synthetic high-resolution in-depth images, thus demonstrating the feasibility of our approach for clinical unmet needs. Furthermore, we quantitatively and qualitatively analyzed the results to find a suitable deep-learning model for our task. The obtained results demonstrate that our proposed dual-element EUS probe with an image-to-image translation network has the potential to provide synthetic high-frequency ultrasound images deep inside tissues.

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