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Morgan Cole

Publications and source records attributed to Morgan Cole.

2 recordsLinked to original sources

PEACC - Precision Emitter for 21 cm Array Coherent Calibration

Foreground mitigation remains a central challenge for 21 cm intensity mapping experiments, which require precise, wideband calibration of telescope beams and gains. We present the Precision Emitter for 21 cm Array Coherent Calibration (PEACC), a digitally synthesized calibration source that generates Gaussian noise across a 1.2 GHz bandwidth, time-synchronized to a 1 pulse-per-second output from a GPS-disciplined oscillator, and optimized for aerial deployment. PEACC uses a dual-source architecture with one unit mounted on an aerial platform and a second reference unit connected directly to the radio data acquisition system; this configuration enables improved sensitivity in the low-SNR regime and direct phase measurement. The system further supports configurable band selection, allowing adaptation to various 21 cm intensity mapping telescopes. We validated PEACC through anechoic chamber measurements and by integrating the source on a drone flown over a local radio dish testbed. In both settings, the correlated channel substantially outperformed the auto-correlation channel across all signal-to-noise regimes of interest, confirming the key advantage of the dual-source architecture. To our knowledge, this is the first published demonstration of a free-space coherent calibration signal synchronized only by clocks, the first deployment of such a source on a drone, and the first published beam measurements made with such a source. Given the growing interest in drone-based calibration for 21 cm arrays, this work establishes the feasibility of high-fidelity digital calibration for next-generation 21 cm instruments, and provides a practical path towards improved foreground control and beam calibration in future arrays.

astro-ph.IM

Radiation damage to normal mammalian tissue in vivo with laser-driven protons at ultra-high instantaneous dose rate

The differential sparing of normal tissues relative to tumor control observed at ultra-high dose rates, referred to as the FLASH effect, has recently gained considerable attention. The therapeutic advantages of FLASH radiotherapy are expected to be further amplified through the use of protons and ions, which enable precise dose deposition at tumor depth while minimizing irradiation of healthy tissues proximal and distal to the target. Nevertheless, the mechanism underlying this sparing effect remains poorly understood. Laser-driven proton accelerators are capable of delivering uniquely high instantaneous dose rates in ultrashort bunches. Here, we report the first in vivo investigation of normal tissue response to laser-driven proton irradiation, with controlled exposures to 8 MeV protons, delivering total doses up to 50 Gy at 2 Gy per laser shot. Our findings reveal a reduction in tissue swelling following laser-driven proton treatment compared with X-ray irradiations at conventional dose rates. RNA sequencing identified differential gene expression associated with immune and epidermal programs following laser-driven proton irradiations at two different dose levels.

physics.med-ph