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Moumita Das

Publications and source records attributed to Moumita Das.

At least 37 records · Page 2Linked to original sources

Fast Falsification of Neural Networks using Property Directed Testing

Neural networks are now extensively used in perception, prediction and control of autonomous systems. Their deployment in safety-critical systems brings forth the need for verification techniques for such networks. As an alternative to exhaustive and costly verification algorithms, lightweight falsification algorithms have been heavily used to search for an input to the system that produces an unsafe output, i.e., a counterexample to the safety of the system. In this work, we propose a falsification algorithm for neural networks that directs the search for a counterexample, guided by a safety property specification. Our algorithm uses a derivative-free sampling-based optimization method. We evaluate our algorithm on 45 trained neural network benchmarks of the ACAS Xu system against 10 safety properties. We show that our falsification procedure detects all the unsafe instances that other verification tools also report as unsafe. Moreover, in terms of performance, our falsification procedure identifies most of the unsafe instances faster, in comparison to the state-of-the-art verification tools for feed-forward neural networks such as NNENUM and Neurify and in many instances, by orders of magnitude.

cs.AI↗

Active Cytoskeletal Composites Display Emergent Tunable Contractility and Restructuring

The cytoskeleton is a model active matter system that controls diverse cellular processes from division to motility. While both active actomyosin dynamics and actin-microtubule interactions are key to the cytoskeleton's versatility and adaptability, an understanding of their interplay is lacking. Here, we couple microscale experiments with mechanistic modeling to elucidate how connectivity, rigidity, and force-generation affect emergent material properties in in vitro composites of actin, tubulin, and myosin. We use time-resolved differential dynamic microscopy and spatial image autocorrelation to show that ballistic contraction occurs in composites with sufficient flexibility and motor density, but that a critical fraction of microtubules is necessary to sustain controlled dynamics. Our active double-network models reveal that percolated actomyosin networks are essential for contraction, but that networks with comparable actin and microtubule densities can uniquely resist mechanical stresses while simultaneously supporting substantial restructuring. Our findings provide a much-needed blueprint for designing cytoskeleton-inspired materials that couple tunability with resilience and adaptability.

cond-mat.soft↗

Rigidity and fracture of fibrous double networks

Tunable mechanics and fracture resistance are hallmarks of biological tissues and highly desired in engineered materials. To elucidate the underlying mechanisms, we study a rigidly percolating double network (DN) made of a stiff and a flexible network. The DN shows remarkable tunability in mechanical response when the stiff network is just above its rigidity percolation threshold and minimal changes far from this threshold. Further, the DN can be modulated to either be extensible, breaking gradually, or stronger, breaking in a more brittle fashion by varying the flexible network's concentration.

cond-mat.soft↗

Interplay between quantum Zeno and anti-Zeno effects in a non-degenerate hyper-Raman nonlinear optical coupler

Quantum Zeno and anti-Zeno effects are studied in an asymmetric nonlinear optical coupler composed of a probe waveguide and a system waveguide. The system is a nonlinear waveguide operating under non-degenerate hyper-Raman process, while both the pump modes in the system are constantly interacting with the probe waveguide. The effect of the presence of probe on the temporal evolution of the system in terms of the number of photons in Stokes and anti-Stokes modes as well as phonon number is quantified as Zeno parameter. The negative (positive) values of the Zeno parameter in the specific mode are considered as the signatures of the quantum Zeno (anti-Zeno)effect in that mode of the system. It is observed that the phase mismatch in Stokes and anti-Stokes generation processes can be controlled to induce a transition between quantum Zeno and anti-Zeno effects for both off-resonant and resonant hyper-Raman process. However, in case of off-resonant hyper-Raman process in the system waveguide, the frequency detuning parameters can also be used analogously to cause the desired crossover. Further, the general nature of the physical system and the perturbative technique used here allowed us to analytically study the possibilities of observing quantum Zeno and anti-Zeno effects in a large number of special cases, including situations where the process is spontaneous, partially spontaneous and/or the system is operated under degenerate hyper-Raman process, or a simple Raman process.

quant-ph↗

Nonstationary, Nonparametric, Nonseparable Bayesian Spatio-Temporal Modeling Using Kernel Convolution of Order Based Dependent Dirichlet Process

In this article, using kernel convolution of order based dependent Dirichlet process (Griffin and Steel (2006)) we construct a nonstationary, nonseparable, nonparametric space-time process, which, as we show, satisfies desirable properties, and includes the stationary, separable, parametric processes as special cases. We also investigate the smoothness properties of our proposed model. Since our model entails an infinite random series, for Bayesian model fitting purpose we must either truncate the series or more appropriately consider a random number of summands, which renders the model dimension a random variable. We attack the variable dimensionality problem using Transdimensional Transformation based Markov Chain Monte Carlo introduced by Das and Bhattacharya (2019b), which can update all the variables and also change dimensions in a single block using essentially a single random variable drawn from some arbitrary density defined on a relevant support. For the sake of completeness we also address the problem of truncating the infinite series by providing a uniform bound on the error incurred by truncating the infinite series. We illustrate the effectiveness of our model and methodologies on a simulated data set and demonstrate that our approach significantly outperforms that of Fuentes and Reich (2013) which is based on principles somewhat similar to ours. We also fit two real, spatial and spatio-temporal datasets with our approach and obtain quite encouraging results in both the cases.

stat.ME↗

Differences in mechanical properties lead to anomalous phase separation in a model cell co-culture

During the morphogenesis of tissues and tumors, cells often interact with neighbors with different mechanical properties, but the understanding of its role is lacking. We use active Brownian Dynamics simulations to study a model co-culture consisting of two types of cells with the same size and self-propulsion speed, but different mechanical stiffness and cell-cell adhesion. As time evolves, the system phase separates out into clusters with distinct morphologies and transport properties for the two cell types. The density structure functions and the growth of cell clusters deviate from behavior characteristic of the phase separation in binary fluids. Our results capture emergent structure and motility previously observed in co-culture experiments and provide mechanistic insights into intercellular phase separation during development and disease.

cond-mat.soft↗

Effect of hydrostatic pressure on ferromagnetism in two-dimensional CrI$_3$

We have investigated the magnetic properties of highly anisotropic layered ferromagnetic semiconductor CrI$_3$ in presence of hydrostatic pressure ($P$). At ambient pressure, magnetization exhibits a clear anomaly below 212 K along with a thermal hysteresis over a wide temperature range (212-180 K), where a first-order structural transition is observed. CrI$_3$ undergoes a second-order ferromagnetic-paramagnetic phase transition with Curie temperature $T_C$=60.4 K. With application of pressure, the transition becomes sharper and $T_C$ is found to increase from 60.4 to 64.9 K as $P$ increases from 0 to 1.0 GPa. $T_C$ increases with $P$ in a sublinear fashion. The thermal hysteresis in magnetization and the increase of $T_C$ with pressure suggest that the spin and lattice degrees of freedom are coupled. The observed increase in $T_C$ has been explained on the basis of change in inter-layer coupling and Cr-I-Cr bond angle with pressure.

cond-mat.mtrl-sci↗

Active and Passive Transport of Cargo in a Corrugated Channel: A Lattice Model Study

Inside cells, cargos such as vesicles and organelles are transported by molecular motors to their correct locations via active motion on cytoskeletal tracks and passive, Brownian diffusion. During the transportation of cargos, motor-cargo complexes (MCC) navigate the confining and crowded environment of the cytoskeletal network and other macromolecules. Motivated by this, we study a minimal two-state model of motor-driven cargo transport in confinement and predict transport properties that can be tested in experiments. We assume that the motion of the MCC is directly affected by the entropic barrier due to confinement if it is in the passive, unbound state, but not in the active, bound state where it moves with a constant bound velocity. We construct a lattice model based on a Fokker Planck description of the two-state system, study it using a kinetic Monte Carlo method and compare our numerical results with analytical expressions for a mean field limit. We find that the effect of confinement strongly depends on the bound velocity and the binding kinetics of the MCC. Confinement effectively reduces the effective diffusivity and average velocity, except when it results in an enhanced average binding rate and thereby leads to a larger average velocity than when unconfined.

cond-mat.soft↗

Active Disassembly and Reassembly of Actin Networks Induces Distinct Biphasic Mechanics

Actin is a key component of the cytoskeleton, which plays central roles in cell motility, division, growth, and tensile strength. To enable this wide range of transient mechanical processes and properties, networks of actin filaments continuously disassemble and reassemble via active de/re-polymerization. However, the question remains as to how de/re-polymerization kinetics of individual actin filaments translate to time-varying mechanics of dis/re-assembling networks. To address this question, to ultimately elucidate the molecular mechanisms that enable cells to exhibit a myriad of transitory mechanical properties, we couple time-resolved active microrheology with microfluidics to measure the time-varying viscoelastic moduli of entangled and crosslinked actin networks during chemically-triggered network disassembly and reassembly. We also develop a corresponding mathematical model that relates the time-evolution of filament length to the resulting time-dependent storage moduli of evolving networks. During disassembly, we find that the moduli exhibit two distinct exponential decays, with experimental time constants of $\sim$169 and $\sim$47 min, which we show arises from a phase transition from a rigid percolated network to a non-rigid regime occurring after $\sim$90 min. During reassembly, measured moduli exhibit linear increase with time for $\sim$90 min, after which steady-state values are achieved. Our theoretical model shows that reassembly mechanics are dominated by elongation kinetics, and that elongation rates are much slower than has been recently assumed. Our measurements shed much needed light onto how polymerization kinetics map to time-varying mechanics of actively evolving cytoskeleton networks, and provide a powerful platform for studying other active and dynamic systems currently under intense investigation.

physics.bio-ph↗

Transdimensional Transformation based Markov Chain Monte Carlo

In this article, we propose a novel and general dimension-hopping MCMC methodology that can update all the parameters as well as the number of parameters simultaneously using simple deterministic transformations of some low-dimensional (often one-dimensional) random variable. This methodology, which has been inspired by the recent Transformation based MCMC (TMCMC) for updating all the parameters simultaneously in general fixed-dimensional set-ups using low-dimensional random variables, facilitates great speed in terms of computation time and provides high acceptance rates, thanks to the low-dimensional random variables which effectively reduce the dimension dramatically. Quite importantly, our transformation based approach provides a natural way to automate the move-types in the variable dimensional problems. We refer to this methodology as Transdimensional Transformation based Markov Chain Monte Carlo (TTMCMC). We develop the theory of TTMCMC, illustrating it with gamma and normal mixtures with unknown number of components, for both simulated and real data sets. Comparisons with RJMCMC demonstrates far superior performance of TTMCMC in terms of mixing, acceptance rate, computational speed and automation. Furthermore, we demonstrate good performance of TTMCMC in multivariate normal mixtures, even for dimension as large as 20. To our knowledge, there exists no application of RJMCMC for such high-dimensional mixtures. Further, we propose a novel methodology to summarize the posterior, providing a way to obtain the mode of the posterior distribution of the densities and the associated highest posterior density credible regions. Based on our method we also propose a criterion to assess convergence of variable-dimensional algorithms. These methods of summarization and convergence assessment are applicable to general problems, not just to mixtures.

stat.CO↗

Chase-and-run dynamics in cell motility and the molecular rupture of interacting active elastic dimers

Cell migration in morphogenesis and cancer metastasis typically involves interplay between different cell types. We construct and study a minimal, one-dimensional model comprised of two different motile cells with each cell represented as an active elastic dimer. The interaction between the two cells via cadherins is modeled as a spring that can rupture beyond a threshold force as it undergoes dynamic loading via the attached motile cells. We obtain a phase diagram consisting of chase-and-run dynamics and clumping dynamics as a function of the stiffness of the interaction spring and the threshold force. We also find that while feedback between cadherins and cell-substrate interaction via integrins accentuates the chase-run behavior, feedback is not necessary for it.

cond-mat.soft↗

Lower order and higher order entanglement in $87Rb$ $5S-5P-5D$ hyperfine manifold modeled as a four-wave mixing process

Possibilities of generation of lower order and higher order intermodal entanglement in 87Rb 5S-5P-5D hyperfine manifold are rigorously investigated using Sen-Mandal perturbative technique by showing the equivalence of the system with the four-wave mixing (FWM) process. The investigation has revealed that for a set of experimentally realizable/relevant parameters we can observe lower order and higher order intermodal entanglement between pump and signal modes, signal and idler modes, and idler and pump modes in a FWM process associated with the 87Rb 5S-5P-5D hyperfine manifold. In addition, trimodal entanglement involving pump, signal and idler modes is also reported.

quant-ph↗

Stability constraints in triplet extension of MSSM

We study the stability constraints on the parameter space of a triplet extension of MSSM. Existence of unbounded from below directions in the potential can spoil successful Electroweak (EW) symmetry breaking by making the corresponding minimum unstable, and hence the model should be free from those directions. Avoiding those directions restricts the parameter space of the model. We derive four stability constraints, of which only three independent from each other. After scanning the model's parameter space for phenomenologically viable data points, we impose the stability constraints and find that only about a quarter of the data points features a stable EW minimum. At those data points featuring stability, $μ$ and the up Higgs soft mass turn out to be smaller than about a TeV in absolute value, which make the mass of the lightest chargino and neutralino smaller than about 700 GeV. Two relevant phenomenological consequences of lifting the unbounded from below directions are that the lightest Higgs boson decay rate to diphoton predicted by the triplet extension of MSSM generally features larger deviations from MSSM and fine tuning is actually higher, that what each of the two would be without imposing stability constraints.

hep-ph↗

The mechanics of anisotropic spring networks

We construct and analyze a model for a disordered linear spring network with anisotropy. The modeling is motivated by, for example, granular systems, nematic elastomers, and ultimately cytoskeletal networks exhibiting some underlying anisotropy. The model consists of a triangular lattice with two different bond occupation probabilities, $p_x$ and $p_y$, for the linear springs. We develop an effective medium theory (EMT) to describe the network elasticity as a function of $p_x$ and $p_y$. We find that the onset of rigidity in the EMT agrees with Maxwell constraint counting. We also find beyond linear behavior in the shear and bulk modulus as a function of occupation probability in the rigid phase for small strains, which differs from the isotropic case. We compare our EMT with numerical simulations to find rather good agreement. Finally, we discuss the implications of extending the reach of effective medium theory as well as draw connections with prior work on both anisotropic and isotropic spring networks.

cond-mat.soft↗

Active elastic dimers: Cells moving on rigid tracks

Experiments suggest that the migration of some cells in the three-dimensional extra cellular matrix bears strong resemblance to one-dimensional cell migration. Motivated by this observation, we construct and study a minimal one-dimensional model cell made of two beads and an active spring moving along a rigid track. The active spring models the stress fibers with their myosin-driven contractility and alpha-actinin-driven extendability, while the friction coefficients of the two beads describe the catch/slip bond behavior of the integrins in focal adhesions. In the absence of active noise, net motion arises from an interplay between active contractility (and passive extendability) of the stress fibers and an asymmetry between the front and back of the cell due to catch bond behavior of integrins at the front of the cell and slip bond behavior of integrins at the back. We obtain reasonable cell speeds with independently estimated parameters. We also study the effects of hysteresis in the active spring, due to catch bond behavior and the dynamics of cross-linking, and the addition of active noise on the motion of the cell. Our model highlights the role of alpha-actinin in three-dimensional cell motility and does not require Arp2/3 actin filament nucleation for net motion.

cond-mat.soft↗

Leptophilic dark matter in gauged $L_μ-L_τ$ extension of MSSM

Positron excess upto energies $\sim$350 GeV has been observed by AMS-02 result and it is consistent with the positron excess observed by PAMELA upto 100 GeV. There is no observed excess of anti-protons over the expected CR background. We propose a leptophilic dark matter with an $U(1)_{L_μ-L_τ}$ gauge extension of MSSM. The dark matter is an admixture of the $L_μ-L_τ$ gaugino and fermionic partners of the extra $SU(2)$ singlet Higgs boson, which break the $L_μ-L_τ$ symmetry. We construct the SM$\otimes U(1)_{ L_μ-L_τ}$ SUSY model which provides the correct relic density of dark matter and is consistent with constrain on $Z'$ from LHC. The large dark matter annihilation cross-section into $μ^{+}μ^{-}$ and $τ^{+}τ^{-}$, needed to explain PAMELA and AMS-02 is achieved by Breit-Wigner resonance.

hep-ph↗

Constraints on TeV scale Majorana neutrino phenomenology from the Vacuum Stability of the Higgs

The vacuum stability condition of the Standard Model Higgs potential with mass in the range of 124-127 GeV puts an upper bound on the Dirac mass of the neutrinos. We study this constraint with the right-handed neutrino masses upto TeV scale. The heavy neutrinos contribute to $ΔL=2$ processes like neutrinoless double beta decay and same-sign-dilepton production in the colliders. The vacuum stability criterion also restricts the light-heavy neutrino mixing and constrains the branching ratio of lepton flavour violating process, like $μ\to e γ$ mediated by the heavy neutrinos. We show that neutrinoless double beta decay with a lifetime $\sim 10^{25}$ years can be observed if the the lightest heavy neutrino mass is $<$ 4.5 TeV. We show that the vacuum stability condition and the experimental bound on $μ\rightarrow e γ$ together put a constrain on heavy neutrino mass $M_R >$ 3.3 TeV. Finally we show that the observation of same-sign-dileptons (SSD) associated with jets at the LHC needs much larger luminosity than available at present. We have estimated the possible maximum cross-section for this process at the LHC and show that with an integrated luminosity 100 $fb^{-1}$ it may be possible to observe the SSD signals as long as $M_R <$ 400 GeV.

hep-ph↗

Generation of scale invariant density perturbations in a conformally invariant Inert Higgs doublet model

If a Higgs field is conformally coupled to gravity, then it can give rise to the scale invariant density perturbations. We make use of this result in a realistic inert Higgs doublet model, where we have a pair of Higgs doublets conformally coupled to the gravity in the early universe. The perturbation of the inert Higgs is shown to be the scale invariant. This gives rise to the density perturbation observed through CMB by its couplings to the standard model Higgs and the subsequent decay. Loop corrections of this conformally coupled system gives rise to electroweak symmetry breaking. We constrain the couplings of the scalar potential by comparing with the amplitude and spectrum of CMB anisotropy measured by WMAP and this model leads to a prediction for the masses of the lightest Higgs and the other scalars.

hep-ph↗