arXiv subjects

Muge Zhang

Publications and source records attributed to Muge Zhang.

3 recordsLinked to original sources

arXiv2026

One Form to Transfer Them All: Pretraining Multilingual Language Models Beyond Native Orthography

Multilingual language models transfer knowledge across languages through shared subword vocabulary, a mechanism that breaks down when related languages use different writing systems. Prior work addresses this via script equalization (romanization or IPA transcription), but direct comparisons are rare; the focus has been on encoder-only models, with most work adapting existing pretrained models. We systematically compare different input representations in autoregressive multilingual pretraining, comparing orthographic text, IPA, and romanization in a controlled setup across three scales (467M, 709M, and 1.03B) on eight languages in four typologically motivated pairs. Across a wide range of downstream tasks on seen and unseen languages, romanized pretraining yields the strongest cross-lingual transfer, and the advantage over text widens with scale. IPA improves over text in most settings but trails romanization. Surprisingly, finetuning a text-pretrained model on romanized data hurts performance on languages already covered by the base model, only marginally helping when the model lacks script coverage. Our results indicate that for multilingual models spanning typologically diverse scripts, to obtain maximum benefits, romanization should be treated as a core design choice applied at pretraining rather than a post hoc fix.

cs.CL↗

arXiv2026

Structural MRI Synthesis for Alzheimer's Disease via Conditional Diffusion on Anatomical Masks

Recent advances in generative machine learning models have significantly improved medical imaging, offering promising solutions for data augmentation, privacy preservation, and improved model generalization. However, synthesizing high-quality structural MRI data for Alzheimer's Disease (AD) remains challenging due to the subtle, region-specific, and progressive anatomical changes associated with neurodegeneration. In this paper, we extend the Med-DDPM conditional diffusion model -- originally designed for brain tumor synthesis -- to generate 3D structural MRIs specifically tailored to AD. We adopted Med-DDPM due to its established stability and structural fidelity compared to other generative models, which makes it particularly suitable for capturing the subtle anatomical changes characteristic of AD. Our approach conditions the diffusion process on anatomical segmentation masks derived from the ADNI dataset, incorporating key AD-relevant brain structures into the generation process. We systematically evaluate the quality and utility of the synthetic images by training segmentation models on real, synthetic, and hybrid (mixed) datasets. Experimental results demonstrate that segmentation models trained exclusively on synthetic data achieve comparable Dice scores (0.6532) to those trained on real data (0.6513), while exhibiting significantly enhanced recall. Notably, models trained on hybrid datasets (mixing real and synthetic images) outperform both real and synthetic-only baselines, achieving a Dice score of 0.7244. These findings underscore the successful use of conditional diffusion models for generating anatomically accurate, AD-specific synthetic MRIs, and highlight their potential for enhancing training data availability, improving diagnostic accuracy, and promoting research reproducibility in neuroimaging studies.

eess.IV↗

arXiv2026

When Cases Get Rare: A Retrieval Benchmark for Off-Guideline Clinical Question Answering

Across medical specialties, clinical practice is anchored in evidence-based guidelines that codify best studied diagnostic and treatment pathways. These pathways routinely fall short for the long tail of real-world care not covered by guidelines. Most medical large language models (LLMs), however, are trained to encode common, guideline-focused medical knowledge in their parameters. Current evaluations test models primarily on recalling and reasoning with this memorized content, often in multiple-choice settings. Given the fundamental importance of evidence-based reasoning in medicine, it is neither feasible nor reliable to depend on memorization in practice. To address this gap, we introduce OGCaReBench, a free-form retrieval-focused benchmark aimed at evaluating LLMs at answering clinical questions that require going beyond typical guidelines. Extracted from published medical case reports and validated by medical experts, OGCaReBench contains long-form clinical questions requiring free-text answers, providing a systematic framework for assessing open-ended medical reasoning in rare, case-based scenarios. Our experiments reveal that even the best-performing baseline (GPT-5.2) correctly answers only 56% of our benchmark with specialized models only reaching 42%. Augmenting models with retrieved medical articles improves this performance to up to 82% (using GPT-5.2) highlighting the importance of evidence-grounding for real-world medical reasoning tasks. This work thus establishes a foundation for benchmarking and advancing both general-purpose and medical LLMs to produce reliable answers in challenging clinical contexts.

cs.CL↗