Na Zhou | Searcharxiv

arXiv2025

TRACE: Contrastive learning for multi-trial time-series data in neuroscience

Modern neural recording techniques such as two-photon imaging or Neuropixel probes allow to acquire vast time-series datasets with responses of hundreds or thousands of neurons. Contrastive learning is a powerful self-supervised framework for learning representations of complex datasets. Existing applications for neural time series rely on generic data augmentations and do not exploit the multi-trial data structure inherent in many neural datasets. Here we present TRACE, a new contrastive learning framework that averages across different subsets of trials to generate positive pairs. TRACE allows to directly learn a two-dimensional embedding, combining ideas from contrastive learning and neighbor embeddings. We show that TRACE outperforms other methods, resolving fine response differences in simulated data. Further, using in vivo recordings, we show that the representations learned by TRACE capture both biologically relevant continuous variation, cell-type-related cluster structure, and can assist data quality control.

q-bio.NC↗

arXiv2024

Higher-order Structure Based Anomaly Detection on Attributed Networks

Anomaly detection (such as telecom fraud detection and medical image detection) has attracted the increasing attention of people. The complex interaction between multiple entities widely exists in the network, which can reflect specific human behavior patterns. Such patterns can be modeled by higher-order network structures, thus benefiting anomaly detection on attributed networks. However, due to the lack of an effective mechanism in most existing graph learning methods, these complex interaction patterns fail to be applied in detecting anomalies, hindering the progress of anomaly detection to some extent. In order to address the aforementioned issue, we present a higher-order structure based anomaly detection (GUIDE) method. We exploit attribute autoencoder and structure autoencoder to reconstruct node attributes and higher-order structures, respectively. Moreover, we design a graph attention layer to evaluate the significance of neighbors to nodes through their higher-order structure differences. Finally, we leverage node attribute and higher-order structure reconstruction errors to find anomalies. Extensive experiments on five real-world datasets (i.e., ACM, Citation, Cora, DBLP, and Pubmed) are implemented to verify the effectiveness of GUIDE. Experimental results in terms of ROC-AUC, PR-AUC, and Recall@K show that GUIDE significantly outperforms the state-of-art methods.

cs.LG↗