arXiv subjects

Nadja Klein

Publications and source records attributed to Nadja Klein.

80 records · Page 5Linked to original sources

arXiv2019

Assessment and adjustment of approximate inference algorithms using the law of total variance

A common method for assessing validity of Bayesian sampling or approximate inference methods makes use of simulated data replicates for parameters drawn from the prior. Under continuity assumptions, quantiles of functions of the simulated parameter values within corresponding posterior distributions are uniformly distributed. Checking for uniformity when a posterior density is approximated numerically provides a diagnostic for algorithm validity. Furthermore, adjustments to achieve uniformity can improve the quality of approximate inference methods. A weakness of this general approach is that it seems difficult to extend beyond scalar functions of interest. The present article develops an alternative to quantile-based checking and adjustment methods which is inherently multivariate. The new approach is based on use of the tower property of conditional expectation and the law of total variance for relating prior and posterior expectations and covariances. For adjustment, approximate inferences are modified so that the correct prior to posterior relationships hold. We illustrate the method in three examples. The first uses an auxiliary model in a likelihood-free inference problem. The second considers corrections for variational Bayes approximations in a deep neural network generalized linear mixed model. Our final application considers a deep neural network surrogate for approximating Gaussian process regression predictive inference.

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arXiv2019

bamlss: A Lego Toolbox for Flexible Bayesian Regression (and Beyond)

Over the last decades, the challenges in applied regression and in predictive modeling have been changing considerably: (1) More flexible model specifications are needed as big(ger) data become available, facilitated by more powerful computing infrastructure. (2) Full probabilistic modeling rather than predicting just means or expectations is crucial in many applications. (3) Interest in Bayesian inference has been increasing both as an appealing framework for regularizing or penalizing model estimation as well as a natural alternative to classical frequentist inference. However, while there has been a lot of research in all three areas, also leading to associated software packages, a modular software implementation that allows to easily combine all three aspects has not yet been available. For filling this gap, the R package bamlss is introduced for Bayesian additive models for location, scale, and shape (and beyond). At the core of the package are algorithms for highly-efficient Bayesian estimation and inference that can be applied to generalized additive models (GAMs) or generalized additive models for location, scale, and shape (GAMLSS), also known as distributional regression. However, its building blocks are designed as "Lego bricks" encompassing various distributions (exponential family, Cox, joint models, ...), regression terms (linear, splines, random effects, tensor products, spatial fields, ...), and estimators (MCMC, backfitting, gradient boosting, lasso, ...). It is demonstrated how these can be easily recombined to make classical models more flexible or create new custom models for specific modeling challenges.

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arXiv2019

In Search of Lost Edges: A Case Study on Reconstructing Financial Networks

To capture the systemic complexity of international financial systems, network data is an important prerequisite. However, dyadic data is often not available, raising the need for methods that allow for reconstructing networks based on limited information. In this paper, we are reviewing different methods that are designed for the estimation of matrices from their marginals and potentially exogenous information. This includes a general discussion of the available methodology that provides edge probabilities as well as models that are focussed on the reconstruction of edge values. Besides summarizing the advantages, shortfalls and computational issues of the approaches, we put them into a competitive comparison using the SWIFT (Society for Worldwide Interbank Financial Telecommunication) MT 103 payment messages network (MT 103: Single Customer Credit Transfer). This network is not only economically meaningful but also fully observed which allows for an extensive competitive horse race of methods. The comparison concerning the binary reconstruction is divided into an evaluation of the edge probabilities and the quality of the reconstructed degree structures. Furthermore, the accuracy of the predicted edge values is investigated. To test the methods on different topologies, the application is split into two parts. The first part considers the full MT 103 network, being an illustration for the reconstruction of large, sparse financial networks. The second part is concerned with reconstructing a subset of the full network, representing a dense medium-sized network. Regarding substantial outcomes, it can be found that no method is superior in every respect and that the preferred model choice highly depends on the goal of the analysis, the presumed network structure and the availability of exogenous information.

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arXiv2019

Bayesian Effect Selection in Structured Additive Distributional Regression Models

We propose a novel spike and slab prior specification with scaled beta prime marginals for the importance parameters of regression coefficients to allow for general effect selection within the class of structured additive distributional regression. This enables us to model effects on all distributional parameters for arbitrary parametric distributions, and to consider various effect types such as non-linear or spatial effects as well as hierarchical regression structures. Our spike and slab prior relies on a parameter expansion that separates blocks of regression coefficients into overall scalar importance parameters and vectors of standardised coefficients. Hence, we can work with a scalar quantity for effect selection instead of a possibly high-dimensional effect vector, which yields improved shrinkage and sampling performance compared to the classical normal-inverse-gamma prior. We investigate the propriety of the posterior, show that the prior yields desirable shrinkage properties, propose a way of eliciting prior parameters and provide efficient Markov Chain Monte Carlo sampling. Using both simulated and three large-scale data sets, we show that our approach is applicable for data with a potentially large number of covariates, multilevel predictors accounting for hierarchically nested data and non-standard response distributions, such as bivariate normal or zero-inflated Poisson.

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arXiv2018

More green space is related to less antidepressant prescription rates in the Netherlands: A Bayesian geoadditive quantile regression approach

Exposure to green space seems to be beneficial for self-reported mental health. In this study we used an objective health indicator, namely antidepressant prescription rates. Current studies rely exclusively upon mean regression models assuming linear associations. It is, however, plausible that the presence of green space is non-linearly related with different quantiles of the outcome antidepressant prescription rates. These restrictions may contribute to inconsistent findings. Our aim was to assess antidepressant prescription rates in relation to green space, and to analyze how the relationship varies non-linearly across different quantiles of antidepressant prescription rates. We used cross-sectional data for the year 2014 at a municipality level in the Netherlands. Ecological Bayesian geoadditive quantile regressions were fitted for the 15, 50, and 85 percent quantiles to estimate green space-prescription rate correlations, controlling for confounders. The results suggested that green space was overall inversely and non-linearly associated with antidepressant prescription rates. More important, the associations differed across the quantiles, although the variation was modest. Significant non-linearities were apparent: The associations were slightly positive in the lower quantile and strongly negative in the upper one. Our findings imply that an increased availability of green space within a municipality may contribute to a reduction in the number of antidepressant prescriptions dispensed. Green space is thus a central health and community asset, whilst a minimum level of 28 percent needs to be established for health gains. The highest effectiveness occurred at a municipality surface percentage higher than 79 percent. This inverse dose-dependent relation has important implications for setting future community-level health and planning policies.

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arXiv2018

Implicit Copulas from Bayesian Regularized Regression Smoothers

We show how to extract the implicit copula of a response vector from a Bayesian regularized regression smoother with Gaussian disturbances. The copula can be used to compare smoothers that employ different shrinkage priors and function bases. We illustrate with three popular choices of shrinkage priors --- a pairwise prior, the horseshoe prior and a g prior augmented with a point mass as employed for Bayesian variable selection --- and both univariate and multivariate function bases. The implicit copulas are high-dimensional, have flexible dependence structures that are far from that of a Gaussian copula, and are unavailable in closed form. However, we show how they can be evaluated by first constructing a Gaussian copula conditional on the regularization parameters, and then integrating over these. Combined with non-parametric margins the regularized smoothers can be used to model the distribution of non-Gaussian univariate responses conditional on the covariates. Efficient Markov chain Monte Carlo schemes for evaluating the copula are given for this case. Using both simulated and real data, we show how such copula smoothing models can improve the quality of resulting function estimates and predictive distributions.

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arXiv2016

Boosting Joint Models for Longitudinal and Time-to-Event Data

Joint Models for longitudinal and time-to-event data have gained a lot of attention in the last few years as they are a helpful technique to approach common a data structure in clinical studies where longitudinal outcomes are recorded alongside event times. Those two processes are often linked and the two outcomes should thus be modeled jointly in order to prevent the potential bias introduced by independent modelling. Commonly, joint models are estimated in likelihood based expectation maximization or Bayesian approaches using frameworks where variable selection is problematic and which do not immediately work for high-dimensional data. In this paper, we propose a boosting algorithm tackling these challenges by being able to simultaneously estimate predictors for joint models and automatically select the most influential variables even in high-dimensional data situations. We analyse the performance of the new algorithm in a simulation study and apply it to the Danish cystic fibrosis registry which collects longitudinal lung function data on patients with cystic fibrosis together with data regarding the onset of pulmonary infections. This is the first approach to combine state-of-the art algorithms from the field of machine-learning with the model class of joint models, providing a fully data-driven mechanism to select variables and predictor effects in a unified framework of boosting joint models.

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arXiv2015

Bayesian structured additive distributional regression with an application to regional income inequality in Germany

We propose a generic Bayesian framework for inference in distributional regression models in which each parameter of a potentially complex response distribution and not only the mean is related to a structured additive predictor. The latter is composed additively of a variety of different functional effect types such as nonlinear effects, spatial effects, random coefficients, interaction surfaces or other (possibly nonstandard) basis function representations. To enforce specific properties of the functional effects such as smoothness, informative multivariate Gaussian priors are assigned to the basis function coefficients. Inference can then be based on computationally efficient Markov chain Monte Carlo simulation techniques where a generic procedure makes use of distribution-specific iteratively weighted least squares approximations to the full conditionals. The framework of distributional regression encompasses many special cases relevant for treating nonstandard response structures such as highly skewed nonnegative responses, overdispersed and zero-inflated counts or shares including the possibility for zero- and one-inflation. We discuss distributional regression along a study on determinants of labour incomes for full-time working males in Germany with a particular focus on regional differences after the German reunification. Controlling for age, education, work experience and local disparities, we estimate full conditional income distributions allowing us to study various distributional quantities such as moments, quantiles or inequality measures in a consistent manner in one joint model. Detailed guidance on practical aspects of model choice including the selection of several competing distributions for labour incomes and the consideration of different covariate effects on the income distribution complete the distributional regression analysis. We find that next to a lower expected income, full-time working men in East Germany also face a more unequal income distribution than men in the West, ceteris paribus.

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