arXiv subjects

Nan Liu

Publications and source records attributed to Nan Liu.

At least 19 recordsLinked to original sources

arXiv2026

Polar Code Based Federated Learning: Convergence Analysis and Resource Allocation

Federated learning (FL) enables collaborative model training across distributed devices without sharing raw data; however, it faces significant communication bottlenecks and channel impairments in practice. Conventional network layer treatments either idealize the channel as error free or apply equal error protection (EEP) to transmitted model updates, failing to account for the inherently unequal importance of quantization bits within a single local model. To address this limitation, we propose a cross layer polar code based FL scheme that leverages the unequal error protection (UEP) property of polar codes under finite block lengths. Specifically, the proposed design selectively protects more significant quantization bits, thereby mitigating the detrimental effects of channel noise. We further provide a rigorous convergence analysis of the proposed scheme, deriving an upper bound on the convergence gap, which we then jointly optimize over the number of quantization bits and the polar code block length across all training iterations. Experimental results demonstrate that both constant and variable block length configurations of our polar code based scheme consistently achieve substantial performance gains over uncoded and LDPC-based EEP benchmarks, with the advantage becoming increasingly pronounced as the channel quality deteriorating. These findings confirm the efficacy of our cross-layer design in enhancing FL robustness and efficiency under realistic channel conditions.

cs.LG↗

arXiv2026

Evaluating Multi-Turn Multimodal Diagnostic Reasoning on Challenging Real-World Clinical Cases

Clinical diagnostic evaluation should not only assess whether models can provide correct diagnoses, but also reflect the realities of clinical practice, including progressive disclosure of multimodal information, dynamic updating of diagnostic hypotheses, and continuous refinement of clinical reasoning. However, existing evaluations of multimodal large language models (MLLMs) typically rely on single-turn or isolated tasks, making it difficult to fully capture the complexity of real-world clinical diagnosis. To bridge this gap, we developed ClinMM-Bench, the largest multi-turn multimodal clinical diagnostic evaluation benchmark to date. ClinMM-Bench contains 1,089 challenging real-world clinical cases and 3,760 medical images across eight specialties. We systematically evaluated 15 representative MLLMs using a two-level evaluation framework that assessed both diagnostic accuracy and diagnostic reasoning quality. Results showed that proprietary models achieved the highest overall diagnostic accuracy, but the proportion of completely correct diagnoses remained limited across all models. In terms of diagnostic reasoning quality, current models can identify plausible diagnostic directions but still have considerable limitations in generating reliable diagnostic reasoning. Error analysis further identified five representative failure modes: information synthesis failure, knowledge mapping error, perception error, premature closure, and visual hallucination.

cs.CL↗

arXiv2026

SIMAX: A Scalable and Interpretable Framework for Multi-Fidelity and Annotated Clinician-Patient Dialogue Simulation

Background. The widespread deployment of ambient digital scribes is driving large-scale capture of clinician-patient dialogues. Human coding of clinical communication data remains costly, inconsistent, and difficult to scale, motivating AI-driven communication coding systems. However, evaluating these systems requires real-world dialogues and human-coded labels, both hard to obtain at scale. Methods. We developed SIMAX (Scalable and Interpretable Framework for Multi-Fidelity and Annotated Clinician-Patient Dialogue Simulation), a framework for generating controlled clinical dialogue data with reference behavioral annotations. SIMAX generates clinician-patient dialogues from predefined clinical scenarios, personas and voice conditions, and target communication behaviors. Behaviors are controlled using two codebooks: the Global Codebook for overall communication quality and the WISER Codebook for specific countable behaviors. We evaluated SIMAX using automated and human quality assessments and an example communication coding system. Results. SIMAX generated 3,388 simulated dialogues across three specialties, multiple visit stages, persona characteristics, and accent conditions. Automated assessment showed mean UTMOS and WV-MOS scores of 3.03 and 2.61, WER and CER of 0.07 and 0.05, and CLAP cosine similarity of 0.41, suggesting reasonable speech naturalness, high transcription fidelity, and positive text-audio correspondence. Human evaluation showed a median MOS of 4.67 and a median clinical realism score of 3.00. Downstream evaluation suggests that SIMAX can assess how a communication coding system responds to behavioral targets and reveal insufficient sensitivity in some dimensions. Conclusions. SIMAX generates controlled and reproducible simulated clinician-patient dialogues, providing a data foundation for developing, validating, and refining communication coding systems.

cs.CL↗

arXiv2026

Foundation VAEs for 3D CT Reconstruction, Augmentation, and Generation

Variational autoencoders (VAEs) compress high resolution CT volumes into compact latents while preserving clinically relevant structure. However, training CT-specific VAEs from scratch or heavily fine-tuning them incurs substantial computational and engineering cost, and often degrades under heterogeneous scanners, protocols, and diseases. This paper makes a progressive stride toward training-free medical VAEs by leveraging a critical observation: a single Foundation VAE, pretrained at scale on natural images and videos, can serve as a unified interface for CT Reconstruction, Augmentation, and Generation. With both encoder and decoder frozen, the Foundation VAE reconstructs CT volumes with preserved anatomy while suppressing acquisition noise; training segmentation models on these reconstructions improves surface accuracy by 3.9% NSD on average for pancreatic tumor and lung tumor. Within the same Foundation VAE latent space, a conditional latent diffusion model achieves 3.9% lower average FVD with 36.2% higher CT CLIP score, and improves multi-disease generation faithfulness across 18 types by 2.76% AUC. These results demonstrate Foundation VAEs as a practical interface for scalable CT representation reuse and faithful CT generation. Our code and demo are available at https://github.com/qic999/Foundation-VAE.

cs.CV↗

arXiv2026

Mechanism-Dependent Antagonism of Auxiliary Information in Substation-Level Load Disaggregation for Distribution Network Planning

Open-source energy system models disaggregate zonal electricity demand to substations through Voronoi-based preprocessing pipelines that combine socioeconomic weighting with auxiliary spatial corrections. Whether the same auxiliary data helps or harms when the weighting component shifts from rule-based to learned has not been investigated. We fix Voronoi partitioning and cross two design axes on metered demand from 1,891 British primary substations: the demand-weighting method and the mechanism through which Nighttime Light (NTL) intensity and substation-proximity signals enter the allocation, giving 15 configurations. Mechanism-isolation experiments further test additive post-correction and random-noise controls to pinpoint the structural cause of any performance reversal. The same auxiliary data reduces RMSE by 41 % on the static base but increases it by 21 % on the GNN base under multiplicative post-correction (p < 0.001 for both); the best static pipeline outperforms the best GNN variant by 19 %. Post-correction on the GNN improves rank-order correlation (p < 0.001) yet worsens absolute error, so correlation-only evaluation masks the calibration penalty. The isolation experiments trace this reversal to the multiplicative correction form under demand conservation constraints, not to signal redundancy; switching to additive post-correction eliminates the antagonism entirely. A transfer check on 13 German primary substations confirms directional replication and shows amplified antagonism where the GNN baseline already explains over 95 % of demand variance. The NTL and proximity signals behind the 41 % static improvement are publicly available at no cost and should be adopted as default corrections in static pipelines; method evaluation should report RMSE and correlation jointly, as the two metrics diverge under post-correction on learned representations.

eess.SY↗

arXiv2026

Distributionally Robust Transfer Learning with Structurally Missing Covariates, with Application to Cross-National Cardiac Arrest Prediction

Deploying clinical prediction models across healthcare systems often fails when key training covariates are unavailable at deployment and labeled outcomes are limited in the target domain. For example, high-performing models for out-of-hospital cardiac arrest (OHCA) rely on detailed prehospital measurements routinely collected in high-resource settings but unavailable in many international registries. Existing methods either discard missing covariates, sacrificing predictive information, or rely on untestable assumptions about their target distribution. We propose DRUM (\underline{D}istributionally \underline{R}obust \underline{U}nsupervised transfer learning with structurally \underline{M}issing covariates), a framework that transfers prediction models to target populations where certain covariates are structurally absent and outcome labels are unavailable. DRUM partitions covariates into shared components ($X$), observed across all settings, and missing components ($A$), observed only in the source. Rather than imputing missing covariates, DRUM optimizes worst-case predictive performance over the unknown target distribution of $A \mid X$ using a neural network generator, with a robustness parameter controlling allowable deviation from the source conditional. We further develop a bias correction procedure that reduces sensitivity to nuisance estimation error. Simulations show substantial improvements in both mean and worst-case prediction error under distribution shift. Applied to cross-national OHCA prediction, transferring models from a US registry to multiple Asian registries where prehospital variables are unrecorded, DRUM yields better-calibrated predictions and improved clinical classification performance across sites.

stat.AP↗

arXiv2026

New NanoSIMS Multielement Isotope Data Reveal CO Novae As Key Sources Of 13C-rich Presolar Silicon Carbide Grains

We present new multielement NanoSIMS isotopic measurements (C, N, Si, Mg-Al, Ti, and Ni) for four putative nova SiC grains and 79 AB SiC grains from the Murchison meteorite to reassess their stellar origins. High-resolution imaging and a revised Mg/Al relative sensitivity factor for SiC yield substantially improved 26Al/27Al ratios and the most reliable multielement characterization to date for 13C-rich presolar SiC grains. To interpret these data, we computed an expanded suite of hydrodynamic CO, ONe, and recurrent nova models spanning a range of white-dwarf masses and pre-enrichment parameters. When all isotopic systems are considered together (C, N, Mg-Al, Si, Ti, and Ni), the CO nova models provide the closest and most self-consistent match to both the putative nova grains and the subset of AB grains lacking s-process signatures. CO novae of low- to intermediate-mass naturally reproduce the observed 14N/15N-26Al/27Al trend, the Si isotope compositions of AB grains which dominantly reflect Galactic chemical evolution (GCE), and the mild Si isotope shifts in putative nova grains relative to the GCE trend defined by AB grains. In contrast, ONe and recurrent nova models fail multiple isotopic constraints simultaneously. These results demonstrate that low- to intermediate-mass CO novae (0.6-1.0 Msun) are the most plausible stellar sources of 13C-rich SiC dust lacking s-process signatures (1-2\% of all presolar SiC), and they establish a multielement, model-anchored framework for quantifying nova contributions to the dust reservoir in the interstellar medium.

astro-ph.SR↗

arXiv2026

EpiCastBench: Datasets and Benchmarks for Multivariate Epidemic Forecasting

The increasing adoption of data-driven decision-making in public health has established epidemic forecasting as a critical area of research. Recent advances in multivariate forecasting models better capture complex temporal dependencies than conventional univariate approaches, which model individual series independently. Despite this potential, the development of robust epidemic forecasting methods is constrained by the lack of high-quality benchmarks comprising diverse multivariate datasets across infectious diseases and geographical regions. To address this gap, we present EpiCastBench, a large-scale benchmarking framework featuring 40 curated (correlated) multivariate epidemic datasets. These publicly available datasets span a wide range of infectious diseases and exhibit diverse characteristics in terms of temporal granularity, series length, and sparsity. We analyze these datasets to identify their global features and structural patterns. To ensure reproducibility and fair comparison, we establish standardized evaluation settings, including a unified forecasting horizon, consistent preprocessing pipelines, diverse performance metrics, and statistical significance testing. By leveraging this framework, we conduct a comprehensive evaluation of 15 multivariate forecasting models spanning statistical baselines to state-of-the-art deep learning and foundation models. All datasets and code are publicly available on Kaggle (https://www.kaggle.com/datasets/aimltsf/epicastbench) and GitHub (https://github.com/aimltsf/EpiCastBench).

cs.LG↗

arXiv2026

Resolving the bias-precision paradox with stochastic causal representation learning for personalized medicine

Estimating individualized treatment effects from longitudinal observational data is central to data-driven medicine, yet existing methods face a fundamental limitation: reducing confounding bias often suppresses clinically informative heterogeneity, degrading patient-specific predictions. Here, we identify this tension as a bias-precision paradox in causal representation learning and introduce sampling-based maximum mean discrepancy (sMMD), a stochastic alignment strategy that replaces global adversarial balancing with subset-level matching. We instantiate this approach in a framework for counterfactual outcome prediction with attribution-grounded interpretability. Across two large-scale ICU cohorts (n = 27,783), our framework improves accuracy under distribution shift, reducing error by up to 11.5% and substantially increasing recall in high-risk tasks. Mechanistic analyses show that sMMD selectively preserves clinically decisive variables. In human-AI evaluation, our method outperforms clinicians-in-training and large language models, and improves clinician accuracy by 14.7% while reducing decision time, enabling interpretable, real-time clinical decision support.

cs.AI↗

arXiv2026

A Versatile AI Agent for Rare Disease Diagnosis and Risk Gene Prioritization

Accurate and timely diagnosis is essential for effective treatment, particularly in the context of rare diseases. However, current diagnostic workflows often lead to prolonged assessment times and low accuracy. To address these limitations, we introduce Hygieia, a multi-modal AI agent system designed to support precision disease diagnosis by integrating diverse data sources, including phenotypic features, genetic profiles, and clinical records. Hygieia features a router-based and knowledge-enhanced framework that mitigates hallucination and tailors diagnostic strategies to different disease categories. Notably, it prioritizes risk-related genomic factors for rare diseases and provides confidence scores to assist clinical decision-making. We conducted a comprehensive evaluation demonstrating that Hygieia achieves state-of-the-art performance across multiple diagnostic benchmarks. In collaboration with clinical experts from Yale School of Medicine and Duke-NUS Medical School, we further validated its practical utility by showing (1) Hygieia's superior diagnostic performance compared to physicians with an improvement from 12%-60% and (2) its effectiveness in assisting clinicians with medical records for handling real-world cases. Our findings indicate that Hygieia not only enhances diagnostic accuracy and interpretability but also significantly reduces clinician workload, highlighting its potential as a valuable tool in clinical decision support systems.

cs.AI↗

arXiv2026

Root-$n$ Asymptotically Normal Maximum Score Estimation

The maximum score method (Manski, 1975, 1985) is a powerful approach for binary choice models, yet it is known to face both practical and theoretical challenges. In particular, the estimator converges at a slower-than-root-$n$ rate to a nonstandard limiting distribution. We investigate conditions under which strictly concave surrogate score functions can be employed to achieve identification through a smooth criterion function. This criterion enables root-$n$ convergence to a normal limiting distribution. While the conditions to guarantee these desired properties are nontrivial, we characterize them in terms of primitive conditions. Extensive simulation studies support, the root-$n$ convergence rate, the asymptotic normality, and the validity of the standard inference methods.

econ.EM↗

arXiv2026

On Demand-Private Coded Caching With Multiple Demands

We consider a coded caching problem with multiple demands under a privacy constraint. In this problem, a server with access to $N$ files serves $K$ users over a shared link, and each user requests $L$ distinct files. The privacy constraint requires that each user obtain no information about the demands of the other users. We propose a new achievable scheme for arbitrary numbers of files and users. The scheme is obtained via a transformation from a non-private coded caching scheme under uncoded placement for $N$ files and $K \cdot \min\{N,KL\}$ users, where each user requests one file and the demands are restricted to a subset of all possible demands. We then derive a converse bound, and the proposed scheme is shown to be order optimal within a factor of 6 of this bound.

cs.IT↗

arXiv2026

Imaging short- and long-range magnetic order in a quantum anomalous Hall insulator

The quantum anomalous Hall effect has been observed in several magnetically doped topological insulators, where its robustness and macroscopic magnetization properties have been taken to suggest the presence of long-range ferromagnetic order. However, experiments in such systems have found evidence for both long- and short-range order, leaving the precise nature of the magnetism in these systems unclear. Here, we use scanning superconducting quantum interference device microscopy to study magnetic domains in V-doped (Bi,Sb)$_2$Te$_3$ exhibiting a quantum anomalous Hall effect with precise quantization. By imaging stray magnetic fields as a function of applied field, we map the formation and evolution of domains through magnetic reversal. We reconstruct the magnetization configuration underlying the measured stray field and find that magnetic domains and crystallographic grains are of similar size. Moreover, magnetic reversal is found to occur through domain expansion, typical of ferromagnets, rather than through nucleation at random sites. Our measurements thus reveal a coexistence of both local magnetic interactions within crystallographic grains and long-range ferromagnetic coupling between grains. This behavior in V-doped (Bi,Sb)$_2$Te$_3$ is markedly distinct from that previously reported for Cr-doped (Bi,Sb)$_2$Te$_3$.

cond-mat.mtrl-sci↗

arXiv2026

Improving Spatial Allocation for Energy System Coupling with Graph Neural Networks

In energy system analysis, coupling models with mismatched spatial resolutions is a significant challenge. A common solution is assigning weights to high-resolution geographic units for aggregation, but traditional models are limited by using only a single geospatial attribute. This paper presents an innovative method employing a self-supervised Heterogeneous Graph Neural Network to address this issue. This method models high-resolution geographic units as graph nodes, integrating various geographical features to generate physically meaningful weights for each grid point. These weights enhance the conventional Voronoi-based allocation method, allowing it to go beyond simply geographic proximity by incorporating essential geographic information.In addition, the self-supervised learning paradigm overcomes the lack of accurate ground-truth data. Experimental results demonstrate that applying weights generated by this method to cluster-based Voronoi Diagrams significantly enhances scalability, accuracy, and physical plausibility, while increasing precision compared to traditional methods.

cs.LG↗

arXiv2026

Communication-efficient distributed hazard difference estimation for heterogeneous multi-site survival data

Multi-site collaboration can power survival models that no single hospital could fit alone, but privacy rules and protected computing environments block patient-level data sharing and the persistent server connections required by iterative federated methods. We present DiSAH (\underline{\textbf{Di}}stributed \underline{\textbf{S}}urvival via \underline{\textbf{A}}dditive \underline{\textbf{H}}azards), a federated algorithm for time-to-event analysis whose closed-form, non-iterative structure removes the need for a dedicated central server. Coordination requires only aggregation of summary statistics, which any site can perform, with no patient-level data leaving the site. DiSAH is the first federated method to estimate hazard differences, the absolute change in event rate attributable to each risk factor, providing an actionable scale for triage, resource allocation, and health-economic evaluation. Across simulations and 47,778 emergency-department patients from the United States and Singapore, DiSAH matches centralized analysis in accuracy and discrimination, recovers mortality risk factors no individual site was powered to detect, and outperforms meta-analysis and local models.

stat.ML↗

arXiv2026

Movable Antenna Assisted Dual-Polarized Multi-Cell Cooperative AirComp: An Alternating Optimization Approach

Over-the-air computation (AirComp) is a key enabler for distributed optimization, since it leverages analog waveform superposition to perform aggregation and thereby mitigates the communication bottleneck caused by iterative information exchange. However, AirComp is sensitive to wireless environment and conventional systems with fixed single-polarized base-station arrays cannot fully exploit spatial degrees of freedom while also suffering from polarization mismatch. To overcome these limitations, this paper proposes a multi-cell cooperative air-computation framework assisted by dual-polarized movable antennas (D-PMA), and formulates a mean squared error (MSE) minimization problem by jointly optimizing the combining matrix, polarization vectors, antenna positions, and user transmit coefficients. The resulting problem is highly nonconvex, so an alternating algorithm is developed in which closed-form updates are obtained for the combining matrix and transmit coefficients. Then a method based on successive convex approximation (SCA) and semidefinite relaxation (SDR) is proposed to refine polarization vectors, and the antenna positions are updated using a gradient-based method. In addition, we develop a statistical-channel-based scheme for optimizing the antenna locations, and we further present the corresponding algorithm to efficiently obtain the solution. Numerical results show that the proposed movable dual-polarized scheme consistently outperforms movable single-polarized and fixed-antenna baselines under both instantaneous and statistical channels.

cs.IT↗

arXiv2026

Symmetry-engineered and electrically tunable in-plane anomalous Hall effect in oxide heterostructures

The family of Hall effects has long served as a premier probe of how symmetry, magnetic order, and topology intertwine in solids. Recently, the in-plane anomalous Hall effect (IP-AHE), a transverse Hall response driven by in-plane magnetization, has emerged as a distinct member of this family, offering innovative spintronic functionalities and illuminating intricate interplay between mirror-symmetry breaking and in-plane magnetic order. However, practical routes to deterministically and reversibly control IP-AHE remain limited. Here, we establish a symmetry-engineered IP-AHE platform, CaRuO3/La2/3Ca1/3MnO3/CaRuO3 heterostructure on NdGaO3(110), that turns strict mirror-symmetry breaking constraints into effective tuning knobs. IP-AHE in these epitaxial trilayers unambiguously couples to the CaRuO3-buffer-induced mirror-symmetry breaking and faithfully reproduces the ferromagnetic hysteresis. Ionic liquid gating further enables reversible reconfigurations of the symmetry breaking, thereby achieving electrical modulation and ON/OFF switching of IP-AHE. This highly tunable IP-AHE platform opens pathways for exploring nontrivial magnetic order and developing programmable Hall functionalities in planar geometries.

cond-mat.str-el↗

arXiv2026

Toward Global Large Language Models in Medicine

Despite continuous advances in medical technology, the global distribution of health care resources remains uneven. The development of large language models (LLMs) has transformed the landscape of medicine and holds promise for improving health care quality and expanding access to medical information globally. However, existing LLMs are primarily trained on high-resource languages, limiting their applicability in global medical scenarios. To address this gap, we constructed GlobMed, a large multilingual medical dataset, containing over 500,000 entries spanning 12 languages, including four low-resource languages. Building on this, we established GlobMed-Bench, which systematically assesses 56 state-of-the-art proprietary and open-weight LLMs across multiple multilingual medical tasks, revealing significant performance disparities across languages, particularly for low-resource languages. Additionally, we introduced GlobMed-LLMs, a suite of multilingual medical LLMs trained on GlobMed, with parameters ranging from 1.7B to 8B. GlobMed-LLMs achieved an average performance improvement of over 40% relative to baseline models, with a more than threefold increase in performance on low-resource languages. Together, these resources provide an important foundation for advancing the equitable development and application of LLMs globally, enabling broader language communities to benefit from technological advances.

cs.CL↗