arXiv subjects

Nan M. Laird

Publications and source records attributed to Nan M. Laird.

2 recordsLinked to original sources

arXiv2011

The EM Algorithm in Genetics, Genomics and Public Health

The popularity of the EM algorithm owes much to the 1977 paper by Dempster, Laird and Rubin. That paper gave the algorithm its name, identified the general form and some key properties of the algorithm and established its broad applicability in scientific research. This review gives a nontechnical introduction to the algorithm for a general scientific audience, and presents a few examples characteristic of its application.

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arXiv2010

The Role of Family-Based Designs in Genome-Wide Association Studies

Genome-Wide Association Studies (GWAS) offer an exciting and promising new research avenue for finding genes for complex diseases. Traditional case-control and cohort studies offer many advantages for such designs. Family-based association designs have long been attractive for their robustness properties, but robustness can mean a loss of power. In this paper we discuss some of the special features of family designs and their relevance in the era of GWAS.

stat.ME↗