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Nanna Berre

Publications and source records attributed to Nanna Berre.

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A cut finite element method for the Biot system of poroelasticity

We propose a novel cut finite element method for the numerical solution of the Biot system of poroelasticity. The Biot system couples elastic deformation of a porous solid with viscous fluid flow and commonly arises on domains with complex geometries that make high-quality volumetric meshing challenging. To address this issue, we employ the cut finite element framework, where the domain boundary is represented independently of the background mesh, which significantly simplifies the meshing process. Our approach builds upon a parameter robust total pressure formulation of the Biot system, which we combine with the cut finite element method to develop a geometrically robust solution scheme, while preserving the parameter robustness. A key ingredient in the theoretical analysis is a modified inf-sup condition which also holds for mixed boundary conditions, leading to stability and optimal error estimates for the proposed formulation. Finally, we provide numerical evidence demonstrating the theoretical properties of the method and showcasing its capabilities by solving the Biot system on a realistic brain geometry.

math.NA

Cut finite element discretizations of cell-by-cell EMI electrophysiology models

The EMI (Extracellular-Membrane-Intracellular) model describes electrical activity in excitable tissue, where the extracellular and intracellular spaces and cellular membrane are explicitly represented. The model couples a system of partial differential equations in the intracellular and extracellular spaces with a system of ordinary differential equations on the membrane. A key challenge for the EMI model is the generation of high-quality meshes conforming to the complex geometries of brain cells. To overcome this challenge, we propose a novel cut finite element method (CutFEM) where the membrane geometry can be represented independently of a structured and easy-to-generated background mesh for the remaining computational domain. Starting from a Godunov splitting scheme, the EMI model is split into separate PDE and ODE parts. The resulting PDE part is a non-standard elliptic interface problem, for which we devise two different CutFEM formulations: one single-dimensional formulation with the intra/extracellular electrical potentials as unknowns, and a multi-dimensional formulation that also introduces the electrical current over the membrane as an additional unknown leading to a penalized saddle point problem. Both formulations are augmented by suitably designed ghost penalties to ensure stability and convergence properties that are insensitive to how the membrane surface mesh cuts the background mesh. For the ODE part, we introduce a new unfitted discretization to solve the membrane bound ODEs on a membrane interface that is not aligned with the background mesh. Finally, we perform extensive numerical experiments to demonstrate that CutFEM is a promising approach to efficiently simulate electrical activity in geometrically resolved brain cells.

math.NA