Nasibeh Asadi Isakan | Searcharxiv

arXiv2025

Automated Tinnitus Detection Through Dual-Modality Neuroimaging: EEG Microstate Analysis and Resting-State fMRI Classification Using Deep Learning

Objective: Tinnitus affects 10-15% of the population yet lacks objective diagnostic biomarkers. This study applied machine learning to EEG and fMRI data to identify neural signatures distinguishing tinnitus patients from healthy controls. Methods: Two datasets were analyzed: 64-channel EEG recordings from 80 participants (40 tinnitus, 40 controls) and resting-state fMRI data from 38 participants (19 tinnitus, 19 controls). EEG analysis extracted microstate features across four to seven clustering states and five frequency bands, producing 440 features per subject. Global Field Power signals were also transformed into wavelet images for deep learning. fMRI data were analyzed using slice-wise convolutional neural networks and hybrid models combining pre-trained architectures (VGG16, ResNet50) with Decision Tree, Random Forest, and SVM classifiers. Model performance was evaluated using 5-fold cross-validation based on accuracy, precision, recall, F1-score, and ROC-AUC. Results: EEG microstate analysis revealed altered network dynamics in tinnitus, particularly reduced gamma-band microstate B occurrence (healthy: 56.56 vs tinnitus: 43.81, p < 0.001) and diminished alpha coverage. Tree-based classifiers achieved up to 98.8% accuracy, while VGG16 on wavelet-transformed EEG yielded 95.4% and 94.1% accuracy for delta and alpha bands, respectively. fMRI analysis identified 12 high-performing axial slices (>=90% accuracy), with slice 17 reaching 99.0%. The hybrid VGG16-Decision Tree model achieved 98.95% +/- 2.94% accuracy. Conclusion: EEG and fMRI provided effective neural biomarkers for tinnitus classification. Tree-based and hybrid models demonstrated superior performance, highlighting tinnitus as a multi-network disorder requiring multimodal analysis.

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arXiv2025

Advanced U-Net Architectures with CNN Backbones for Automated Lung Cancer Detection and Segmentation in Chest CT Images

This study investigates the effectiveness of U-Net architectures integrated with various convolutional neural network (CNN) backbones for automated lung cancer detection and segmentation in chest CT images, addressing the critical need for accurate diagnostic tools in clinical settings. A balanced dataset of 832 chest CT images (416 cancerous and 416 non-cancerous) was preprocessed using Contrast Limited Adaptive Histogram Equalization (CLAHE) and resized to 128x128 pixels. U-Net models were developed with three CNN backbones: ResNet50, VGG16, and Xception, to segment lung regions. After segmentation, CNN-based classifiers and hybrid models combining CNN feature extraction with traditional machine learning classifiers (Support Vector Machine, Random Forest, and Gradient Boosting) were evaluated using 5-fold cross-validation. Metrics included accuracy, precision, recall, F1-score, Dice coefficient, and ROC-AUC. U-Net with ResNet50 achieved the best performance for cancerous lungs (Dice: 0.9495, Accuracy: 0.9735), while U-Net with VGG16 performed best for non-cancerous segmentation (Dice: 0.9532, Accuracy: 0.9513). For classification, the CNN model using U-Net with Xception achieved 99.1 percent accuracy, 99.74 percent recall, and 99.42 percent F1-score. The hybrid CNN-SVM-Xception model achieved 96.7 percent accuracy and 97.88 percent F1-score. Compared to prior methods, our framework consistently outperformed existing models. In conclusion, combining U-Net with advanced CNN backbones provides a powerful method for both segmentation and classification of lung cancer in CT scans, supporting early diagnosis and clinical decision-making.

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