arXiv subjects

Nassir Navab

Publications and source records attributed to Nassir Navab.

At least 181 records · Page 10Linked to original sources

arXiv2025

VibNet: Vibration-Boosted Needle Detection in Ultrasound Images

Precise percutaneous needle detection is crucial for ultrasound (US)-guided interventions. However, inherent limitations such as speckles, needle-like artifacts, and low resolution make it challenging to robustly detect needles, especially when their visibility is reduced or imperceptible. To address this challenge, we propose VibNet, a learning-based framework designed to enhance the robustness and accuracy of needle detection in US images by leveraging periodic vibration applied externally to the needle shafts. VibNet integrates neural Short-Time Fourier Transform and Hough Transform modules to achieve successive sub-goals, including motion feature extraction in the spatiotemporal space, frequency feature aggregation, and needle detection in the Hough space. Due to the periodic subtle vibration, the features are more robust in the frequency domain than in the image intensity domain, making VibNet more effective than traditional intensity-based methods. To demonstrate the effectiveness of VibNet, we conducted experiments on distinct \textit{ex vivo} porcine and bovine tissue samples. The results obtained on porcine samples demonstrate that VibNet effectively detects needles even when their visibility is severely reduced, with a tip error of $1.61\pm1.56~mm$ compared to $8.15\pm9.98~mm$ for UNet and $6.63\pm7.58~mm$ for WNet, and a needle direction error of $1.64\pm1.86^{\circ}$ compared to $9.29\pm15.30^{\circ}$ for UNet and $8.54\pm17.92^{\circ}$ for WNet. Code: https://github.com/marslicy/VibNet.

eess.IV↗

arXiv2025

Robust Tumor Segmentation with Hyperspectral Imaging and Graph Neural Networks

Segmenting the boundary between tumor and healthy tissue during surgical cancer resection poses a significant challenge. In recent years, Hyperspectral Imaging (HSI) combined with Machine Learning (ML) has emerged as a promising solution. However, due to the extensive information contained within the spectral domain, most ML approaches primarily classify individual HSI (super-)pixels, or tiles, without taking into account their spatial context. In this paper, we propose an improved methodology that leverages the spatial context of tiles for more robust and smoother segmentation. To address the irregular shapes of tiles, we utilize Graph Neural Networks (GNNs) to propagate context information across neighboring regions. The features for each tile within the graph are extracted using a Convolutional Neural Network (CNN), which is trained simultaneously with the subsequent GNN. Moreover, we incorporate local image quality metrics into the loss function to enhance the training procedure's robustness against low-quality regions in the training images. We demonstrate the superiority of our proposed method using a clinical ex vivo dataset consisting of 51 HSI images from 30 patients. Despite the limited dataset, the GNN-based model significantly outperforms context-agnostic approaches, accurately distinguishing between healthy and tumor tissues, even in images from previously unseen patients. Furthermore, we show that our carefully designed loss function, accounting for local image quality, results in additional improvements. Our findings demonstrate that context-aware GNN algorithms can robustly find tumor demarcations on HSI images, ultimately contributing to better surgery success and patient outcome.

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arXiv2025

From Open-Vocabulary to Vocabulary-Free Semantic Segmentation

Open-vocabulary semantic segmentation enables models to identify novel object categories beyond their training data. While this flexibility represents a significant advancement, current approaches still rely on manually specified class names as input, creating an inherent bottleneck in real-world applications. This work proposes a Vocabulary-Free Semantic Segmentation pipeline, eliminating the need for predefined class vocabularies. Specifically, we address the chicken-and-egg problem where users need knowledge of all potential objects within a scene to identify them, yet the purpose of segmentation is often to discover these objects. The proposed approach leverages Vision-Language Models to automatically recognize objects and generate appropriate class names, aiming to solve the challenge of class specification and naming quality. Through extensive experiments on several public datasets, we highlight the crucial role of the text encoder in model performance, particularly when the image text classes are paired with generated descriptions. Despite the challenges introduced by the sensitivity of the segmentation text encoder to false negatives within the class tagging process, which adds complexity to the task, we demonstrate that our fully automated pipeline significantly enhances vocabulary-free segmentation accuracy across diverse real-world scenarios.

cs.CV↗

arXiv2025

Robotic CBCT Meets Robotic Ultrasound

The multi-modality imaging system offers optimal fused images for safe and precise interventions in modern clinical practices, such as computed tomography - ultrasound (CT-US) guidance for needle insertion. However, the limited dexterity and mobility of current imaging devices hinder their integration into standardized workflows and the advancement toward fully autonomous intervention systems. In this paper, we present a novel clinical setup where robotic cone beam computed tomography (CBCT) and robotic US are pre-calibrated and dynamically co-registered, enabling new clinical applications. This setup allows registration-free rigid registration, facilitating multi-modal guided procedures in the absence of tissue deformation. First, a one-time pre-calibration is performed between the systems. To ensure a safe insertion path by highlighting critical vasculature on the 3D CBCT, SAM2 segments vessels from B-mode images, using the Doppler signal as an autonomously generated prompt. Based on the registration, the Doppler image or segmented vessel masks are then mapped onto the CBCT, creating an optimally fused image with comprehensive detail. To validate the system, we used a specially designed phantom, featuring lesions covered by ribs and multiple vessels with simulated moving flow. The mapping error between US and CBCT resulted in an average deviation of 1.72+-0.62 mm. A user study demonstrated the effectiveness of CBCT-US fusion for needle insertion guidance, showing significant improvements in time efficiency, accuracy, and success rate. Needle intervention performance improved by approximately 50% compared to the conventional US-guided workflow. We present the first robotic dual-modality imaging system designed to guide clinical applications. The results show significant performance improvements compared to traditional manual interventions.

cs.RO↗

arXiv2025

Enhancing Patient Acceptance of Robotic Ultrasound through Conversational Virtual Agent and Immersive Visualizations

Robotic ultrasound systems can enhance medical diagnostics, but patient acceptance is a challenge. We propose a system combining an AI-powered conversational virtual agent with three mixed reality visualizations to improve trust and comfort. The virtual agent, powered by a large language model, engages in natural conversations and guides the ultrasound robot, enhancing interaction reliability. The visualizations include augmented reality, augmented virtuality, and fully immersive virtual reality, each designed to create patient-friendly experiences. A user study demonstrated significant improvements in trust and acceptance, offering valuable insights for designing mixed reality and virtual agents in autonomous medical procedures.

cs.HC↗

arXiv2025

From large language models to multimodal AI: A scoping review on the potential of generative AI in medicine

Generative artificial intelligence (AI) models, such as diffusion models and OpenAI's ChatGPT, are transforming medicine by enhancing diagnostic accuracy and automating clinical workflows. The field has advanced rapidly, evolving from text-only large language models for tasks such as clinical documentation and decision support to multimodal AI systems capable of integrating diverse data modalities, including imaging, text, and structured data, within a single model. The diverse landscape of these technologies, along with rising interest, highlights the need for a comprehensive review of their applications and potential. This scoping review explores the evolution of multimodal AI, highlighting its methods, applications, datasets, and evaluation in clinical settings. Adhering to PRISMA-ScR guidelines, we systematically queried PubMed, IEEE Xplore, and Web of Science, prioritizing recent studies published up to the end of 2024. After rigorous screening, 144 papers were included, revealing key trends and challenges in this dynamic field. Our findings underscore a shift from unimodal to multimodal approaches, driving innovations in diagnostic support, medical report generation, drug discovery, and conversational AI. However, critical challenges remain, including the integration of heterogeneous data types, improving model interpretability, addressing ethical concerns, and validating AI systems in real-world clinical settings. This review summarizes the current state of the art, identifies critical gaps, and provides insights to guide the development of scalable, trustworthy, and clinically impactful multimodal AI solutions in healthcare.

cs.AI↗

arXiv2025

Gaze-Guided Robotic Vascular Ultrasound Leveraging Human Intention Estimation

Medical ultrasound has been widely used to examine vascular structure in modern clinical practice. However, traditional ultrasound examination often faces challenges related to inter- and intra-operator variation. The robotic ultrasound system (RUSS) appears as a potential solution for such challenges because of its superiority in stability and reproducibility. Given the complex anatomy of human vasculature, multiple vessels often appear in ultrasound images, or a single vessel bifurcates into branches, complicating the examination process. To tackle this challenge, this work presents a gaze-guided RUSS for vascular applications. A gaze tracker captures the eye movements of the operator. The extracted gaze signal guides the RUSS to follow the correct vessel when it bifurcates. Additionally, a gaze-guided segmentation network is proposed to enhance segmentation robustness by exploiting gaze information. However, gaze signals are often noisy, requiring interpretation to accurately discern the operator's true intentions. To this end, this study proposes a stabilization module to process raw gaze data. The inferred attention heatmap is utilized as a region proposal to aid segmentation and serve as a trigger signal when the operator needs to adjust the scanning target, such as when a bifurcation appears. To ensure appropriate contact between the probe and surface during scanning, an automatic ultrasound confidence-based orientation correction method is developed. In experiments, we demonstrated the efficiency of the proposed gaze-guided segmentation pipeline by comparing it with other methods. Besides, the performance of the proposed gaze-guided RUSS was also validated as a whole on a realistic arm phantom with an uneven surface.

cs.RO↗

arXiv2025

Medical Multimodal Model Stealing Attacks via Adversarial Domain Alignment

Medical multimodal large language models (MLLMs) are becoming an instrumental part of healthcare systems, assisting medical personnel with decision making and results analysis. Models for radiology report generation are able to interpret medical imagery, thus reducing the workload of radiologists. As medical data is scarce and protected by privacy regulations, medical MLLMs represent valuable intellectual property. However, these assets are potentially vulnerable to model stealing, where attackers aim to replicate their functionality via black-box access. So far, model stealing for the medical domain has focused on classification; however, existing attacks are not effective against MLLMs. In this paper, we introduce Adversarial Domain Alignment (ADA-STEAL), the first stealing attack against medical MLLMs. ADA-STEAL relies on natural images, which are public and widely available, as opposed to their medical counterparts. We show that data augmentation with adversarial noise is sufficient to overcome the data distribution gap between natural images and the domain-specific distribution of the victim MLLM. Experiments on the IU X-RAY and MIMIC-CXR radiology datasets demonstrate that Adversarial Domain Alignment enables attackers to steal the medical MLLM without any access to medical data.

cs.CR↗

arXiv2025

Location-Free Scene Graph Generation

Scene Graph Generation (SGG) is a visual understanding task, aiming to describe a scene as a graph of entities and their relationships with each other. Existing works rely on location labels in form of bounding boxes or segmentation masks, increasing annotation costs and limiting dataset expansion. Recognizing that many applications do not require location data, we break this dependency and introduce location-free scene graph generation (LF-SGG). This new task aims at predicting instances of entities, as well as their relationships, without the explicit calculation of their spatial localization. To objectively evaluate the task, the predicted and ground truth scene graphs need to be compared. We solve this NP-hard problem through an efficient branching algorithm. Additionally, we design the first LF-SGG method, Pix2SG, using autoregressive sequence modeling. We demonstrate the effectiveness of our method on three scene graph generation datasets as well as two downstream tasks, image retrieval and visual question answering, and show that our approach is competitive to existing methods while not relying on location cues.

cs.CV↗

arXiv2025

SCRREAM : SCan, Register, REnder And Map:A Framework for Annotating Accurate and Dense 3D Indoor Scenes with a Benchmark

Traditionally, 3d indoor datasets have generally prioritized scale over ground-truth accuracy in order to obtain improved generalization. However, using these datasets to evaluate dense geometry tasks, such as depth rendering, can be problematic as the meshes of the dataset are often incomplete and may produce wrong ground truth to evaluate the details. In this paper, we propose SCRREAM, a dataset annotation framework that allows annotation of fully dense meshes of objects in the scene and registers camera poses on the real image sequence, which can produce accurate ground truth for both sparse 3D as well as dense 3D tasks. We show the details of the dataset annotation pipeline and showcase four possible variants of datasets that can be obtained from our framework with example scenes, such as indoor reconstruction and SLAM, scene editing & object removal, human reconstruction and 6d pose estimation. Recent pipelines for indoor reconstruction and SLAM serve as new benchmarks. In contrast to previous indoor dataset, our design allows to evaluate dense geometry tasks on eleven sample scenes against accurately rendered ground truth depth maps.

cs.CV↗

arXiv2024

Conformable Convolution for Topologically Aware Learning of Complex Anatomical Structures

While conventional computer vision emphasizes pixel-level and feature-based objectives, medical image analysis of intricate biological structures necessitates explicit representation of their complex topological properties. Despite their successes, deep learning models often struggle to accurately capture the connectivity and continuity of fine, sometimes pixel-thin, yet critical structures due to their reliance on implicit learning from data. Such shortcomings can significantly impact the reliability of analysis results and hinder clinical decision-making. To address this challenge, we introduce Conformable Convolution, a novel convolutional layer designed to explicitly enforce topological consistency. Conformable Convolution learns adaptive kernel offsets that preferentially focus on regions of high topological significance within an image. This prioritization is guided by our proposed Topological Posterior Generator (TPG) module, which leverages persistent homology. The TPG module identifies key topological features and guides the convolutional layers by applying persistent homology to feature maps transformed into cubical complexes. Our proposed modules are architecture-agnostic, enabling them to be integrated seamlessly into various architectures. We showcase the effectiveness of our framework in the segmentation task, where preserving the interconnectedness of structures is critical. Experimental results on three diverse datasets demonstrate that our framework effectively preserves the topology in the segmentation downstream task, both quantitatively and qualitatively.

eess.IV↗

arXiv2024

DynaMoN: Motion-Aware Fast and Robust Camera Localization for Dynamic Neural Radiance Fields

The accurate reconstruction of dynamic scenes with neural radiance fields is significantly dependent on the estimation of camera poses. Widely used structure-from-motion pipelines encounter difficulties in accurately tracking the camera trajectory when faced with separate dynamics of the scene content and the camera movement. To address this challenge, we propose Dynamic Motion-Aware Fast and Robust Camera Localization for Dynamic Neural Radiance Fields (DynaMoN). DynaMoN utilizes semantic segmentation and generic motion masks to handle dynamic content for initial camera pose estimation and statics-focused ray sampling for fast and accurate novel-view synthesis. Our novel iterative learning scheme switches between training the NeRF and updating the pose parameters for an improved reconstruction and trajectory estimation quality. The proposed pipeline shows significant acceleration of the training process. We extensively evaluate our approach on two real-world dynamic datasets, the TUM RGB-D dataset and the BONN RGB-D Dynamic dataset. DynaMoN improves over the state-of-the-art both in terms of reconstruction quality and trajectory accuracy. We plan to make our code public to enhance research in this area.

cs.CV↗

arXiv2024

VoxNeRF: Bridging Voxel Representation and Neural Radiance Fields for Enhanced Indoor View Synthesis

The generation of high-fidelity view synthesis is essential for robotic navigation and interaction but remains challenging, particularly in indoor environments and real-time scenarios. Existing techniques often require significant computational resources for both training and rendering, and they frequently result in suboptimal 3D representations due to insufficient geometric structuring. To address these limitations, we introduce VoxNeRF, a novel approach that utilizes easy-to-obtain geometry priors to enhance both the quality and efficiency of neural indoor reconstruction and novel view synthesis. We propose an efficient voxel-guided sampling technique that allocates computational resources selectively to the most relevant segments of rays based on a voxel-encoded geometry prior, significantly reducing training and rendering time. Additionally, we incorporate a robust depth loss to improve reconstruction and rendering quality in sparse view settings. Our approach is validated with extensive experiments on ScanNet and ScanNet++ where VoxNeRF outperforms existing state-of-the-art methods and establishes a new benchmark for indoor immersive interpolation and extrapolation settings.

cs.CV↗

arXiv2024

ESCAPE: Equivariant Shape Completion via Anchor Point Encoding

Shape completion, a crucial task in 3D computer vision, involves predicting and filling the missing regions of scanned or partially observed objects. Current methods expect known pose or canonical coordinates and do not perform well under varying rotations, limiting their real-world applicability. We introduce ESCAPE (Equivariant Shape Completion via Anchor Point Encoding), a novel framework designed to achieve rotation-equivariant shape completion. Our approach employs a distinctive encoding strategy by selecting anchor points from a shape and representing all points as a distance to all anchor points. This enables the model to capture a consistent, rotation-equivariant understanding of the object's geometry. ESCAPE leverages a transformer architecture to encode and decode the distance transformations, ensuring that generated shape completions remain accurate and equivariant under rotational transformations. Subsequently, we perform optimization to calculate the predicted shapes from the encodings. Experimental evaluations demonstrate that ESCAPE achieves robust, high-quality reconstructions across arbitrary rotations and translations, showcasing its effectiveness in real-world applications without additional pose estimation modules.

cs.CV↗

arXiv2024

OphCLIP: Hierarchical Retrieval-Augmented Learning for Ophthalmic Surgical Video-Language Pretraining

Surgical practice involves complex visual interpretation, procedural skills, and advanced medical knowledge, making surgical vision-language pretraining (VLP) particularly challenging due to this complexity and the limited availability of annotated data. To address the gap, we propose OphCLIP, a hierarchical retrieval-augmented vision-language pretraining framework specifically designed for ophthalmic surgical workflow understanding. OphCLIP leverages the OphVL dataset we constructed, a large-scale and comprehensive collection of over 375K hierarchically structured video-text pairs with tens of thousands of different combinations of attributes (surgeries, phases/operations/actions, instruments, medications, as well as more advanced aspects like the causes of eye diseases, surgical objectives, and postoperative recovery recommendations, etc). These hierarchical video-text correspondences enable OphCLIP to learn both fine-grained and long-term visual representations by aligning short video clips with detailed narrative descriptions and full videos with structured titles, capturing intricate surgical details and high-level procedural insights, respectively. Our OphCLIP also designs a retrieval-augmented pretraining framework to leverage the underexplored large-scale silent surgical procedure videos, automatically retrieving semantically relevant content to enhance the representation learning of narrative videos. Evaluation across 11 datasets for phase recognition and multi-instrument identification shows OphCLIP's robust generalization and superior performance.

cs.CV↗

arXiv2024

MRSegmentator: Multi-Modality Segmentation of 40 Classes in MRI and CT

Purpose: To develop and evaluate a deep learning model for multi-organ segmentation of MRI scans. Materials and Methods: The model was trained on 1,200 manually annotated 3D axial MRI scans from the UK Biobank, 221 in-house MRI scans, and 1228 CT scans from the TotalSegmentator dataset. A human-in-the-loop annotation workflow was employed, leveraging cross-modality transfer learning from an existing CT segmentation model to segment 40 anatomical structures. The annotation process began with a model based on transfer learning between CT and MR, which was iteratively refined based on manual corrections to predicted segmentations. The model's performance was evaluated on MRI examinations obtained from the German National Cohort (NAKO) study (n=900) from the AMOS22 dataset (n=60) and from the TotalSegmentator-MRI test data (n=29). The Dice Similarity Coefficient (DSC) and Hausdorff Distance (HD) were used to assess segmentation quality, stratified by organ and scan type. The model and its weights will be open-sourced. Results: MRSegmentator demonstrated high accuracy for well-defined organs (lungs: DSC 0.96, heart: DSC 0.94) and organs with anatomic variability (liver: DSC 0.96, kidneys: DSC 0.95). Smaller structures showed lower accuracy (portal/splenic veins: DSC 0.64, adrenal glands: DSC 0.69). On external validation using NAKO data, mean DSC ranged from 0.85 $\pm$ 0.08 for T2-HASTE to 0.91 $\pm$ 0.05 for in-phase sequences. The model generalized well to CT, achieving mean DSC of 0.84 $\pm$ 0.11 on AMOS CT data. Conclusion: MRSegmentator accurately segments 40 anatomical structures in MRI across diverse datasets and imaging protocols, with additional generalizability to CT images. This open-source model will provide a valuable tool for automated multi-organ segmentation in medical imaging research. It can be downloaded from https://github.com/hhaentze/MRSegmentator.

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arXiv2024

Extrapolating Prospective Glaucoma Fundus Images through Diffusion Model in Irregular Longitudinal Sequences

The utilization of longitudinal datasets for glaucoma progression prediction offers a compelling approach to support early therapeutic interventions. Predominant methodologies in this domain have primarily focused on the direct prediction of glaucoma stage labels from longitudinal datasets. However, such methods may not adequately encapsulate the nuanced developmental trajectory of the disease. To enhance the diagnostic acumen of medical practitioners, we propose a novel diffusion-based model to predict prospective images by extrapolating from existing longitudinal fundus images of patients. The methodology delineated in this study distinctively leverages sequences of images as inputs. Subsequently, a time-aligned mask is employed to select a specific year for image generation. During the training phase, the time-aligned mask resolves the issue of irregular temporal intervals in longitudinal image sequence sampling. Additionally, we utilize a strategy of randomly masking a frame in the sequence to establish the ground truth. This methodology aids the network in continuously acquiring knowledge regarding the internal relationships among the sequences throughout the learning phase. Moreover, the introduction of textual labels is instrumental in categorizing images generated within the sequence. The empirical findings from the conducted experiments indicate that our proposed model not only effectively generates longitudinal data but also significantly improves the precision of downstream classification tasks.

cs.CV↗

arXiv2024

VISAGE: Video Synthesis using Action Graphs for Surgery

Surgical data science (SDS) is a field that analyzes patient data before, during, and after surgery to improve surgical outcomes and skills. However, surgical data is scarce, heterogeneous, and complex, which limits the applicability of existing machine learning methods. In this work, we introduce the novel task of future video generation in laparoscopic surgery. This task can augment and enrich the existing surgical data and enable various applications, such as simulation, analysis, and robot-aided surgery. Ultimately, it involves not only understanding the current state of the operation but also accurately predicting the dynamic and often unpredictable nature of surgical procedures. Our proposed method, VISAGE (VIdeo Synthesis using Action Graphs for Surgery), leverages the power of action scene graphs to capture the sequential nature of laparoscopic procedures and utilizes diffusion models to synthesize temporally coherent video sequences. VISAGE predicts the future frames given only a single initial frame, and the action graph triplets. By incorporating domain-specific knowledge through the action graph, VISAGE ensures the generated videos adhere to the expected visual and motion patterns observed in real laparoscopic procedures. The results of our experiments demonstrate high-fidelity video generation for laparoscopy procedures, which enables various applications in SDS.

cs.CV↗